Decreased Task-Related HRV Is Associated With Inhibitory Dysfunction Through Functional Inter-Region Connectivity of PFC in Major Depressive Disorder

Zhou, Hongliang; Dai, Zhongpeng; Lu, Hua; Jiang, Hanliang; Tian, Shui; Han, Yinglin; Lin, Pinhua; Wang, Haofei; Lü, Qing; Yao, Zhjjian

doi:10.3389/fpsyt.2019.00989

Cited by 12 publications

(9 citation statements)

References 52 publications

(67 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Low HRV has been associated with greater mortality 19 . In non-pregnant populations, low or excessive as well as unstable HF are associated with psychiatric diagnoses 12 , 20 , 21 . In addition to HF, other HRV measures have also been associated with anxiety disorders.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Heart rate variability in late pregnancy: exploration of distinctive patterns in relation to maternal mental health

et al. 2021

View full text Add to dashboard Cite

Exploration of photoplethysmography (PPG), a technique that can be translated to the clinic, has the potential to assess the autonomic nervous system (ANS) through heart rate variable (HRV) in pregnant individuals. This novel study explores the complexity of mental health of individuals in a clinical sample responding to a task in late pregnancy; finding those with several types of past or current anxiety disorders, greater trait anxiety, or greater exposure to childhood traumatic events had significantly different HRV findings from the others in the cohort. Lower high frequency (HF), a measure of parasympathetic activity, was found for women who met the criteria for the history of obsessive–compulsive disorder (OCD) (p = 0.004) compared with women who did not meet the criteria for OCD, and for women exposed to greater than five childhood traumatic events (p = 0.006) compared with those exposed to four or less childhood traumatic events. Conversely higher low frequency (LF), a measure thought to be impacted by sympathetic system effects, and the LF/HF ratio was found for those meeting criteria for a panic disorder (p = 0.006), meeting criteria for social phobia (p = 0.002), had elevated trait anxiety (p = 0.006), or exposure to greater than five childhood traumatic events (p = 0.004). This study indicates further research is needed to understand the role of PPG and in assessing ANS functioning in late pregnancy. Study of the impact of lower parasympathetic functioning and higher sympathetic functioning separately and in conjunction at baseline and in relation to tasks during late pregnancy has the potential to identify individuals that require more support and direct intervention.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Several studies have gone further to study the links between HRV and prefrontal cortex (PFC) function 12 , 28 – 30 . Important as both increased and decreased PFC functioning are linked to psychiatric diagnoses including MDD, bipolar disorder, obsessive–compulsive disorder (OCD), PTSD, and social phobia 20 , 31 – 34 .…”

Section: Introductionmentioning

confidence: 99%

Heart rate variability in late pregnancy: exploration of distinctive patterns in relation to maternal mental health

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In our population, VNS non-responders seem to be characterized by a sudden autonomic imbalance, a decrease in parasympathetic activity related to early seizure activity, possibly targeting areas of the central autonomic network. A recently published study involving HRV measurements in patients with major depression showed that a decreased task-related HRV is associated with inhibitory dysfunction in structures of the prefrontal cortex [28]. HRV measures are often used to assess the integrity of the central autonomic system and its contribution to recovery in severe disorders of consciousness.…”

Section: Discussionmentioning

confidence: 99%

Pre-ictal heart rate variability alterations in focal onset seizures and response to vagus nerve stimulation

Hödl

Olbert

Mahringer

et al. 2021

Seizure

View full text Add to dashboard Cite

“…A recent study of PWH who presented with gastrointestinal symptoms observed that vagal dysfunction was associated with bacterial outgrowth in the small intestines that was, in turn, linked to greater systemic inflammation ( 54 ). Efferent vagal pathways that are modulated by decreases in depressive symptoms have the potential to alter the gut microbiota and decrease microbial translocation, as evidenced by the effects of vagal stimulation ( 55 , 56 ). Prior clinical research in people without HIV observed that increased vagal tone is an important indicator of a favorable response to cognitive-behavioral treatments for depression ( 57 , 58 ).…”

Section: This Is Now: Microbiome-gut-brain Axis Alterations Relevant ...mentioning

confidence: 99%

Through the Looking-Glass: Psychoneuroimmunology and the Microbiome-Gut-Brain Axis in the Modern Antiretroviral Therapy Era

et al. 2022

View full text Add to dashboard Cite

Objective: Depression, substance use disorders, and other neuropsychiatric comorbidities are common in people with HIV (PWH), but the underlying mechanisms are not sufficiently understood. HIV-induced damage to the gastrointestinal tract potentiates residual immune dysregulation in PWH receiving effective antiretroviral therapy. However, few studies among PWH have examined the relevance of microbiomegut-brain axis: bidirectional crosstalk between the gastrointestinal tract, immune system, and central nervous system. Methods: A narrative review was conducted to integrate findings from 159 articles relevant to psychoneuroimmunology (PNI) and microbiome-gut-brain axis research in PWH. Results: Early PNI studies demonstrated that neuroendocrine signaling via the hypothalamic-pituitary-adrenal axis and autonomic nervous system could partially account for the associations of psychological factors with clinical HIV progression. This review highlights the need for PNI studies examining the mechanistic relevance of the gut microbiota for residual immune dysregulation, tryptophan catabolism, and oxytocin release as key biological determinants of neuropsychiatric comorbidities in PWH (i.e., body-to-mind pathways). It also underscores the continued relevance of neuroendocrine signaling via the hypothalamic-pituitary-adrenal axis, autonomic nervous system, and oxytocin release in modifying microbiome-gut-brain axis functioning (i.e., mind-to-body pathways). Conclusions: Advancing our understanding of PNI and microbiome-gut-brain axis pathways relevant to depression, substance use disorders, and other neuropsychiatric comorbidities in PWH can guide the development of novel biobehavioral interventions to optimize health outcomes. Recommendations are provided for biobehavioral and neurobehavioral research investigating bidirectional PNI and microbiomegut-brain axis pathways among PWH in the modern antiretroviral therapy era.

show abstract

Decreased Task-Related HRV Is Associated With Inhibitory Dysfunction Through Functional Inter-Region Connectivity of PFC in Major Depressive Disorder

Cited by 12 publications

References 52 publications

Heart rate variability in late pregnancy: exploration of distinctive patterns in relation to maternal mental health

Heart rate variability in late pregnancy: exploration of distinctive patterns in relation to maternal mental health

Pre-ictal heart rate variability alterations in focal onset seizures and response to vagus nerve stimulation

Through the Looking-Glass: Psychoneuroimmunology and the Microbiome-Gut-Brain Axis in the Modern Antiretroviral Therapy Era

Contact Info

Product

Resources

About