Decreased sleep duration is associated with increased fMRI responses to emotional faces in children

Reidy, Brooke L; Hamann, Stephan; Inman, Cory S.; Johnson, Katrina C.; Brennan, Patricia A.

doi:10.1016/j.neuropsychologia.2016.01.028

Cited by 26 publications

(23 citation statements)

References 43 publications

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“…Second, poor sleep quality, which is associated with disrupted circadian rhythmicity, is predictive of elevated morning cortisol ( Hatzinger et al , 2008 , 2010 ; Balbo et al , 2010 ; Bostock and Steptoe, 2013 ; Abell et al , 2016 ) and we found that self-reported poor sleep quality was associated with increased amygdala reactivity among participants scanned in the morning. Notably, this finding is further congruent with prior evidence that sleep deprivation is associated with increased amygdala reactivity ( Yoo et al , 2007 ; Motomura et al , 2013 , 2014 ; Simon et al , 2015 ; Reidy et al , 2016 ).…”

Section: Discussionsupporting

confidence: 87%

“…fear conditioning) are potentiated during the active phase of the circadian cycle, we hypothesized that amygdala reactivity would be highest during the morning and lowest during the afternoon and evening. Further in light of evidence that sleep deprivation enhances amygdala reactivity to threat ( Yoo et al , 2007 ; Motomura et al , 2013 , 2014 ; Simon et al , 2015 ; Reidy et al , 2016 ), we predicted that temporally-dependent amygdala reactivity would be moderated by subjective sleep quality.…”

Section: Introductionmentioning

confidence: 99%

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An earlier time of scan is associated with greater threat-related amygdala reactivity

Baranger

Margolis

Hariri

et al. 2017

Social Cognitive and Affective Neuroscience

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Time-dependent variability in mood and anxiety suggest that related neural phenotypes, such as threat-related amygdala reactivity, may also follow a diurnal pattern. Here, using data from 1,043 young adult volunteers, we found that threat-related amygdala reactivity was negatively coupled with time of day, an effect which was stronger in the left hemisphere (β = −0.1083, p-fdr = 0.0012). This effect was moderated by subjective sleep quality (β = −0.0715, p-fdr = 0.0387); participants who reported average and poor sleep quality had relatively increased left amygdala reactivity in the morning. Bootstrapped simulations suggest that similar cross-sectional samples with at least 300 participants would be able to detect associations between amygdala reactivity and time of scan. In control analyses, we found no associations between time and V1 activation. Our results provide initial evidence that threat-related amygdala reactivity may vary diurnally, and that this effect is potentiated among individuals with average to low sleep quality. More broadly, our results suggest that considering time of scan in study design or modeling time of scan in analyses, as well as collecting additional measures of circadian variation, may be useful for understanding threat-related neural phenotypes and their associations with behavior, such as fear conditioning, mood and anxiety symptoms, and related phenotypes.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

An earlier time of scan is associated with greater threat-related amygdala reactivity

Baranger

Margolis

Hariri

et al. 2017

Social Cognitive and Affective Neuroscience

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“…We found that the GMV of the right superior occipital gyrus was negatively correlated with the severity of sleep disturbances. A recent fMRI study reported altered emotion-dependent functional connectivity between the occipital cortex and other brain regions and its positive association with sleep duration in a sample of school-aged children 56 . In contrast, a recent neuroimaging study conducted in a sample of primary insomnia patients found an increased volume and altered functional connectivity in the left superior occipital gyrus 40 .…”

Section: Discussionmentioning

confidence: 96%

Structural Alterations in Large-scale Brain Networks and Their Relationship with Sleep Disturbances in the Adolescent Population

Sung

Park

Kim

et al. 2020

Sci Rep

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Although sleep disturbances are highly prevalent in adolescents, neuroimaging evidence on the effects of sleep disturbances on their developing brains remains limited. Therefore, we explored gray matter volumes (GMVs) at the whole-brain level and investigated their relationship to sleep disturbances in a sample of Korean adolescents in the general population. We recruited participants from one middle school and high school. All participants and their legal guardians gave informed consent before participating in our study. We used component 5 of the Pittsburgh Sleep Quality Index to measure sleep disturbances and conducted a voxel-based morphometry-DARTEL procedure to measure GMVs. We performed partial correlation analyses to examine whether the GMVs were associated with sleep disturbances. A total of 56 adolescents participated in this study. Our results revealed that GMVs in multiple global regions were negatively correlated with sleep disturbances. Moreover, most of these identified regions belong to large-scale brain networks categorized by functional neuroimaging studies. We found an association between regional GMVs in multiple global regions involved in large-scale networks and the severity of sleep disturbances in the adolescent population. Based on this evidence and previous neuroimaging evidence, we suggest that structural alterations in the networks may be linked to sleep disturbances. Sleep disturbances and their harmful effects have been increasingly reported in many children and adolescents worldwide 1. In a representative sample of 17,102 children and adolescents, approximately 20% reported sleep disturbances and an additional 13% reported difficulties falling asleep 1. Similarly, 38% of 1,000 school going adolescents suffered from sleep disturbances 2. A recent population-based study reported that 26% of 1,180 Brazilian children and adolescents aged 0-19 years experienced sleep disturbances, had inadequate sleep habits, and had sleep durations lower than the recommended duration 3. While sleep disturbances in adolescents may seem normative, sleep problems are known to be associated with a wide spectrum of physical and mental health problems, such as obesity, growth hormone deficiency, substance abuse, depression, suicidality, anxiety, difficulties with impulse control, and the compulsive use of social media and video games 4-12. Moreover, strong associations between sleep problems and various cognitive functions, including memory, learning, and attention, have been reported by an established body of previous research 13-15 .

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“…Compared to other measures, such as the Pittsburgh Global Sleep Quality Index (PSQI; Backhaus, Junghanns, Broocks, Riemann, & Hohagen, 2002 ), the sleep measure in this study has not been empirically validated in prior work. While the questionnaire used in this study has face validity and other studies have used self-report measures to investigate neural correlates of subjectively reported sleep amount and tiredness (Killgore, 2013 ; Klumpp et al, 2017 ; Reidy et al, 2016 ), the questions rely on retrospective self-report up to 3 days before testing, which may have impacted results based on self-report bias that has been previously associated with psychological difficulties (Lauderdale et al, 2008 ). Moreover, sleep quality, onset, or latency are sleep measures that may be more informative indices than sleep amount measured in this study.…”

Section: Discussionmentioning

confidence: 99%

“…Sleep disturbances have been associated with alterations in subcortical and mPFC circuits, described above as key structures underlying emotion processing and showing abnormalities in pathological anxiety. These sleep-related neural effects have been proposed as a possible mechanism underlying the relationship between abnormal sleep regulation and emotional difficulties (Goldstein & Walker, 2014 ; Gruber & Cassoff, 2014 ; Reidy, Hamann, Inman, Johnson, & Brennan, 2016 ). Dysregulation of top-down inhibitory control of prefrontal regions over limbic structures has been associated with sleep deprivation, leading to abnormal emotional response (Gujar, Yoo, Hu, & Walker, 2011 ; Kaufmann et al, 2016 ; Walker, 2009 ).…”

Section: Introductionmentioning

confidence: 99%

Sleep-amount differentially affects fear-processing neural circuitry in pediatric anxiety: A preliminary fMRI investigation

Carlisi

Hilbert

Guyer

et al. 2017

Cogn Affect Behav Neurosci

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Insufficient sleep, as well as the incidence of anxiety disorders, both peak during adolescence. While both conditions present perturbations in fear-processing-related neurocircuitry, it is unknown whether these neurofunctional alterations directly link anxiety and compromised sleep in adolescents. Fourteen anxious adolescents (AAs) and 19 healthy adolescents (HAs) were compared on a measure of sleep amount and neural responses to negatively valenced faces during fMRI. Group differences in neural response to negative faces emerged in the dorsal anterior cingulate cortex (dACC) and the hippocampus. In both regions, correlation of sleep amount with BOLD activation was positive in AAs, but negative in HAs. Follow-up psychophysiological interaction (PPI) analyses indicated positive connectivity between dACC and dorsomedial prefrontal cortex, and between hippocampus and insula. This connectivity was correlated negatively with sleep amount in AAs, but positively in HAs. In conclusion, the presence of clinical anxiety modulated the effects of sleep-amount on neural reactivity to negative faces differently among this group of adolescents, which may contribute to different clinical significance and outcomes of sleep disturbances in healthy adolescents and patients with anxiety disorders.Electronic supplementary materialThe online version of this article (10.3758/s13415-017-0535-7) contains supplementary material, which is available to authorized users.

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Decreased sleep duration is associated with increased fMRI responses to emotional faces in children

Cited by 26 publications

References 43 publications

An earlier time of scan is associated with greater threat-related amygdala reactivity

An earlier time of scan is associated with greater threat-related amygdala reactivity

Structural Alterations in Large-scale Brain Networks and Their Relationship with Sleep Disturbances in the Adolescent Population

Sleep-amount differentially affects fear-processing neural circuitry in pediatric anxiety: A preliminary fMRI investigation

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