Decreased serum platelet derived growth factor BB levels in acute and increased in chronic pancreatitis

Stojek, Magdalena; Adrych, Krystian; Rojek, Lukasz; Smoczyński, Marian; Śledziński, Tomasz; Szrok, Sylwia; Świerczyński, Julian

doi:10.3748/wjg.v20.i36.13127

Cited by 11 publications

(6 citation statements)

References 22 publications

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“…Among others, fibroblast growth factor and platelet-derived growth factor (PDGF) are the major cytokines that initiate and afterward support fibroblast proliferation and chemotactic activity resulting in the necrotic area encapsulation[ 26 - 28 ]. Clinical observations of Stojek et al [ 29 ] indirectly confirmed this assumption. According to findings of this scientific group, serum levels of PDGF-BB is significantly increased in patients with chronic pancreatitis, which is associated with chronic inflammation and fibrosis.…”

Section: Discussionmentioning

confidence: 74%

Routine laboratory parameters in patients with necrotizing pancreatitis by the time of operative pancreatic debridement: Food for thought

Susak¹,

Opalchuk²,

Tkachenko³

et al. 2022

WJGS

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BACKGROUND Timing of invasive intervention such as operative pancreatic debridement (OPD) in patients with acute necrotizing pancreatitis (ANP) is linked to the degree of encapsulation in necrotic collections and controlled inflammation. Additional markers of these processes might assist decision-making on the timing of surgical intervention. In our opinion, it is logical to search for such markers among routine laboratory parameters traditionally used in ANP patients, considering simplicity and cost-efficacy of routine laboratory methodologies. AIM To evaluate laboratory variables in ANP patients in the preoperative period for the purpose of their use in the timing of surgery. METHODS A retrospective analysis of routine laboratory parameters in 53 ANP patients undergoing OPD between 2017 and 2020 was performed. Dynamic changes of routine hematological and biochemical indices were examined in the preoperative period. Patients were divided into survivors and non-survivors. Survivors were divided into subgroups with short and long post-surgery length of stay (LOS) in hospital. Correlation analysis was used to evaluate association of laboratory variables with LOS. Logistic regression was used to assess risk factors for patient mortality. RESULTS Seven patients (15%) with severe acute pancreatitis (SAP) and 46 patients (85%) with moderately SAP (MSAP) were included in the study. Median age of participants was 43.2 years; 33 (62.3%) were male. Pancreatitis etiology included biliary (15%), alcohol (80%), and idiopathic/other (5%). Median time from diagnosis to OPD was ≥ 4 wk. Median postoperative LOS was at the average of 53 d. Mortality was 19%. Progressive increase of platelet count in preoperative period was associated with shortened LOS. Increased aspartate aminotransferase and direct bilirubin (DB) levels the day before the OPD along with weak progressive decrease of DB in preoperative period were reliable predictors for ANP patient mortality. CONCLUSION Multifactorial analysis of dynamic changes of routine laboratory variables can be useful for a person-tailored timing of surgical intervention in ANP patients.

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Section: Discussionmentioning

confidence: 74%

Routine laboratory parameters in patients with necrotizing pancreatitis by the time of operative pancreatic debridement: Food for thought

Susak¹,

Opalchuk²,

Tkachenko³

et al. 2022

WJGS

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“…However, congruent findings by independent sources serve to increase overall confidence in the direction of expression change for these factors. Additionally, our study was focused on expression of factors in chronic pancreatitis rather than acute pancreatitis, a condition that may have a distinct profile of inflammatory mediators 17 .…”

Section: Discussionmentioning

confidence: 99%

Local and Systemic Expression of Immunomodulatory Factors in Chronic Pancreatitis

Komar

Hart²,

Cruz‐Monserrate

et al. 2017

Pancreas

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Inflammatory and fibrotic events that drive chronic pancreatitis (CP) are likely orchestrated via signaling of soluble cytokines and chemokines systemically and within the pancreas. However, a comprehensive summary of the expression of such factors during CP has not been reported to date. This information is important given continued interest in targeting cytokines that influence CP pathogenesis. Reported data on the expression change of soluble immunomodulatory factors in human CP patients were identified via a literature search using a single search term. Thirty-one articles meeting the pre-specified inclusion criteria were identified to generate a compiled data summary. Compiled data demonstrated up-regulation of several factors in the blood or pancreas microenvironment of CP patients. Nine factors were elevated in both compartments, including fractalkine, interferon gamma (IFN-γ), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), macrophage inhibitory cytokine 1 (MIC-1), neutrophil gelatinase-associated lipocalin (NGAL/LCN2), transforming growth factor beta (TGF-β), and tumor necrosis factor alpha (TNF-α). Most up-regulated factors could be classified into one of several functional groups, including inflammation, chemotaxis, angiogenesis, bone remodeling, extracellular matrix remodeling, and pain. Following further validation, these factors may be used as biomarkers for disease diagnosis, identification of comorbidities, or as potential therapeutic targets.

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“…PDGF-BB plasma levels in patients with aseptic loosening of their hip prosthesis were 40 (8.4) pg/mL (0.04 ng/mL), mean (SE), whereas those with stable prostheses, without clinical and radiological signs of loosening was 90 (16) pg/mL, determined by enzyme immunoassay (Cenni et al, 2005). Stojek et al (2014) found that healthy subjects were recorded to have serum PDGF-BB levels of 6.2 ± 0.76 ng/mL (mean ± SE) measured using ELISA. Another study reported a median serum concentration of PDGF-BB at 3.89 ng/mL in healthy participants measured using ELISA (Solchaga et al, 2013).…”

Section: Endogenous Level Of Pdgf-bb In Humanmentioning

confidence: 99%

A review on the safety of growth factors commonly used in cultivated meat production

Huang,

Ko,

Paes

et al. 2024

Comp Rev Food Sci Food Safe

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Growth factors are commonly added to cell culture media in cellular agriculture to mimic the endogenous process of proliferation and differentiation of cells. Many of these growth factors are endogenous to humans and known to be present in the edible tissues and milk of food animals. However, there is little or no information on the use of growth factors intentionally added in food production before the advent of cultivated meat. Ten commonly used growth factors have been reviewed to include information on their mode of action, bioavailability, occurrence in food and food animals, endogenous levels in humans, as well as exposure and toxicological information drawn from relevant animal studies and human clinical trials with a focus on oral exposure. In addition, a comparison of homology of growth factors was done to compare the sequence homology of growth factors from humans and domestic animal species commonly consumed as food, such as bovine, porcine, and poultry. This information has been gathered as the starting point to determine the safety of use of growth factors in cultivated meat meant for human consumption. The change in levels of growth factors measured in human milk and bovine milk after pasteurization and high‐temperature treatment is discussed to give an indication of how commercial food processing can affect the levels of growth factors in food. The concept of substantial equivalence is also discussed together with a conservative exposure estimation. More work on how to integrate in silico assessments into the routine safety assessment of growth factors is needed.

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Decreased serum platelet derived growth factor BB levels in acute and increased in chronic pancreatitis

Abstract: The serum levels of some growth factors and cytokines differ significantly in AP, WOPN and CP. These data suggest that selected growth factors and cytokines may be considered as potential diagnostic biomarkers in patients with pancreatic diseases.

Cited by 11 publications

References 22 publications

Routine laboratory parameters in patients with necrotizing pancreatitis by the time of operative pancreatic debridement: Food for thought

Routine laboratory parameters in patients with necrotizing pancreatitis by the time of operative pancreatic debridement: Food for thought

Local and Systemic Expression of Immunomodulatory Factors in Chronic Pancreatitis

A review on the safety of growth factors commonly used in cultivated meat production

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