Decreased serum level of suprabasin in patients with nickel allergy

Metal Allergy: State-of-the-Art Mechanisms, Biomarkers, Hypersensitivity to Implants

“… Outcomes Exposition to Metal Ref. ↑ metal-specific CD154 + CD4 + Tmem (overexpression of TRAV9-2 and CDR3 histidine) Allergic and non-allergic subjects stimulated with Ni, Co or Pd (PBMC) [ 67 , 68 ] ↑ IL-5 Ni-allergic patients (PBMC) [ 69 ] Ni-allergy patients, differentiation between independent Ni or cross-reactivity of Ni/Pd allergy (PBMC) [ 71 ] Cross reactivity between Ni/Cr and Pd Sensitization with Ni or Cr, challenge with Pd (mice model) [ 70 ] Skin barrier defects: ↓ terminal differentiation—FLG, FLG2, LOR, LCEs, tight junction—CLDN1/CLDN8, lipid metabolism—FA2H, FABP7 Biopsies from healthy subjects after Ni-topical application [ 73 ] Cellular infiltrates: ↑ CD3 + T, CD11c + myeloid DC, DC-LAMP + mature DC, MBP + eosinophils, FOXP3 + Treg ↑ M1, mast cells, neutrophils, NK, CD4 + Tmem, CD8 + T Biopsies from Ni-allergic patients [ 74 ] ↓ M2, resting mast cells, Tγδ, Treg ↓ SBSN Ni-allergic patients (serum) [ 75 ] ↑ Sema3A (activates MAPK and TNF-α) Ni-induced allergy (mouse ear tissue) [ 76 ...…”

“…Ni is mainly absorbed from the upper digestive tract, so Ni-allergic patients may have reduced SBSN expression in the upper gastrointestinal tract, which can promote Ni absorption, enhancing allergy. The level of SBSN is lower in intrinsic atopic dermatitis patients, which have a high complication rate of Ni-allergy than in extrinsic patients [ 75 ].…”