Decreased serum bilirubin is associated with arterial stiffness in men

Li, Y.; Meng, Songyan; Meng, Chao; Yu, Weidong; Wang, R.-t.

doi:10.1016/j.numecd.2011.09.004

Cited by 25 publications

(23 citation statements)

References 39 publications

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“…The discrepancy between our data and previous reports (45)(46)(47) could be related to the type of population analyzed. Our observation adds to the recently reported correlation between serum CEC and IMT as a marker of early atherosclerosis ( 4 ).…”

Section: Resultscontrasting

confidence: 99%

ABCA1-dependent serum cholesterol efflux capacity inversely correlates with pulse wave velocity in healthy subjects

Favari

Ronda

Adorni

et al. 2013

Journal of Lipid Research

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Section: Resultscontrasting

confidence: 99%

ABCA1-dependent serum cholesterol efflux capacity inversely correlates with pulse wave velocity in healthy subjects

Favari

Ronda

Adorni

et al. 2013

Journal of Lipid Research

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“…An interesting result was presented by Li et al [29]. Their analysis confirmed a negative correlation of bilirubin concentration with arterial stiffness [28,29]. We were able to determine statistically significant differences of bilirubin concentration between results recorded on AD and on NADIR; however, no such significance was determined for groups with and without endothelial dysfunction.…”

Section: Discussionsupporting

confidence: 59%

“…In their results neither total bilirubin nor the administered atazanavir had any effect on improving endothelial function. An interesting result was presented by Li et al [29]. Their analysis confirmed a negative correlation of bilirubin concentration with arterial stiffness [28,29].…”

Section: Discussionmentioning

confidence: 72%

The effects of CD4 nadirs on vessel stiffness in HIV patients undergoing antiretroviral therapy

et al. 2017

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A b s t r a c tBackground: There are many factors associated with human immunodeficiency virus (HIV) patients having a greater risk of cardiovascular diseases (CVD). HIV damages vessel endothelium through chronic inflammation, which, combined with dyslipidaemia, arterial hypertension, and antiretroviral therapy leads to the progression of atherosclerotic changes. Aim:Our goal was to determine if a CD4 nadir along with immunological, inflammatory, biochemical, and metabolic markers can be associated with higher vessel stiffness and therefore an increased risk of CVD in patients undergoing antiretroviral therapy for HIV. Methods:Endothelial damage was evaluated in 20 patients (including four female) during successful antiretroviral therapy. We assessed the endothelial stiffness by recording the reactive hyperaemia of peripheral arteries using an Endo-PAT2000 (ITAMAR ® ) device. This device allowed us to measure the arterial tonometry and to determine the augmentation index for a pulse rate of 75/min (AI@75). We set the normal value for vessel stiffness at reactive hyperaemia index (RHI) > 1.67, as recommended by the manufacturer. Additionally, we recorded the length of antiretroviral therapy, number of CD4 lymphocytes, CD4 nadir, HIV viremia, and biochemical and immunologic results. Finally, we compared patients with normal and dysfunctional endothelium. Results:The only parameter significantly differentiating between the group with and group without endothelium dysfunction was platelet count (p = 0.012). Conclusions:We were not able to confirm the significance of a CD4 nadir in the progression of endothelial stiffness in HIV patients. However, platelet values could be an important complementary marker for assessing the risk for CVD amongst HIV patients undergoing antiretroviral treatment.

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“…Nevertheless, in numerous studies moderately elevated STB levels have been shown to be linked to increased survival and a decreased risk of cardiovascular events (Djousse et al 2001;Vitek et al 2002;Tanaka et al 2009;Li et al 2013;Vitek 2012;Oda 2014;Tatami et al 2014;Agrawal and Sharma 2015;Kundur et al 2015). Although the characteristics, metabolism, and various effects of this pigment has been of abiding interest to both clinicians and researchers, there is still no general consensus with respect to the association between STB levels and longevity in the elderly (cf.…”

Section: Discussionmentioning

confidence: 99%

“…For a long time, there has been an increasing focus on STB as a negative risk factor of cardiovascular mortality and an indicator of improved survival in both sexes, but especially in men (Djousse et al 2001;Temme et al 2001;Vitek et al 2002;Perlstein et al 2008;Kimm et al 2009;Lin et al 2009;Tanaka et al 2009;Lin et al 2010;Li et al 2013;Ong et al 2014;Kunutsor 2015;Li et al 2015). According to the oxidation-inflammation theory of aging (De la Fuente and Miquel 2009;Franceschi and Campisi 2014;, elevated serum bilirubin levels that protect against oxidative damage, atherosclerosis, CVD, tissue inflammation, etc.…”

Section: Introductionmentioning

confidence: 99%

Association of serum bilirubin with longevity: Evidence from a retrospective longitudinal study and cross-sectional data

Chmielewski

Strzelec

Chmielowiec

et al. 2017

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Bilirubin is a potent antioxidant and an important anti-inflammatory factor. Therefore, there has been an increasing focus on serum bilirubin as a negative risk factor of cardiovascular mortality in men and an indicator of improved survival in both sexes, but the direct mechanisms of these links and the causes of sex differences are not well understood. Moreover, the evidence from longitudinal studies on effects of bilirubin on longevity is limited. In this study, we retrospectively analyzed two groups of older adults to explore age-dependent changes in serum bilirubin levels and their associations with long-term survival in both sexes. Longitudinal data from 142 individuals (68 men and 74 women) aged 45 to 70 years were compared with cross-sectional data from 225 individuals (113 men and 112 women). The latter group was divided into four categories of survival, i.e. 53, 63, 68, and 76+ based on data on lifespan. ANOVA, t-test, and regression analysis were run. The analysis of the longitudinal data showed an increase in serum total bilirubin levels in men (0.3038e 0.093x , R 2 = 0.667) and women (0.1838e, R 2 = 0.950), while the analysis of cross-sectional data revealed a U-shaped pattern of age-related changes in men (0.001x2 -0.1263x + 4.4524, R 2 = 0.999) but an inverted U-shaped pattern in women (0.0006x 2 + 0.072x -1.6924, R 2 = 0.195). On balance, these results suggest that elevated but normal bilirubin levels might confer a survival advantage in older men but not women. Alternatively, the positive relationship between serum total bilirubin and lifespan was not causal but coincidental. Further studies are needed to elucidate the direct mechanisms of the association between serum bilirubin levels and longevity in elderly people of both sexes.

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Decreased serum bilirubin is associated with arterial stiffness in men

Cited by 25 publications

References 39 publications

ABCA1-dependent serum cholesterol efflux capacity inversely correlates with pulse wave velocity in healthy subjects

ABCA1-dependent serum cholesterol efflux capacity inversely correlates with pulse wave velocity in healthy subjects

The effects of CD4 nadirs on vessel stiffness in HIV patients undergoing antiretroviral therapy

Association of serum bilirubin with longevity: Evidence from a retrospective longitudinal study and cross-sectional data

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