Decreased serum alfa2-HS-glycoprotein concentration in patients with primary biliary cirrhosis

Kopper, László; Szalay, Ferenç; Nemesánszky, E; Telegdy, László; Jakab, L; Romics, L

doi:10.1016/s0168-8278(97)80483-7

Cited by 14 publications

(15 citation statements)

References 5 publications

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“…It may be the consequence of reduced fetuin-A synthesis by hepatocytes. This hypothesis is supported by the fact that subjects with advanced stages of liver failure have lower fetuin-A concentrations compared to those in less advanced stages 31 . However, not only the severity of the liver disease may influence on fetuin-A levels but also proinflammatory cytokines may play the additional but not main role 31 .…”

Section: Fetuin-a As a Marker Of Liver Functionmentioning

confidence: 90%

“…This hypothesis is supported by the fact that subjects with advanced stages of liver failure have lower fetuin-A concentrations compared to those in less advanced stages 31 . However, not only the severity of the liver disease may influence on fetuin-A levels but also proinflammatory cytokines may play the additional but not main role 31 . Daveau et al reported that IL-1, Il-6 and TNF-α inhibit synthesis of fetuin-A in rat liver and human HepG2 cells and elevated levels of these cytokines have been found in some diseases mentioned above 33,34 .…”

Section: Fetuin-a As a Marker Of Liver Functionmentioning

confidence: 90%

“…Studies in humans with severe liver damage such as cirrhosis (alcoholic liver cirrhosis, primary biliary cirrhosis), chronic hepatitis and cancer indicate that serum fetuin-A levels are decreased in such patients 5,31,32 . It may be the consequence of reduced fetuin-A synthesis by hepatocytes.…”

Section: Fetuin-a As a Marker Of Liver Functionmentioning

confidence: 99%

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Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature

et al. 2015

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Section: Fetuin-a As a Marker Of Liver Functionmentioning

confidence: 90%

Section: Fetuin-a As a Marker Of Liver Functionmentioning

confidence: 90%

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Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature

et al. 2015

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“…The protein is synthesized predominantly in the liver, and its serum level is decreased in patients with liver cirrhosis and hepatocellular cancer because of an impaired hepatic synthetic capacity. 25,26 The synthesis of human AHSG in the liver is downregulated by pro-inflammatory cytokines, indicating that this protein is a negative acute-phase reactant. 27 Estrogen might also influence the production of the protein, as suggested by the changes in its serum levels after menopause and estrogen therapy.…”

Section: Discussionmentioning

confidence: 99%

Preeclampsia is associated with decreased serum α2-HS glycoprotein (fetuin-A) concentration

et al. 2009

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The purpose of this study was to determine serum a 2 -HS glycoprotein (AHSG) concentration and its diagnostic accuracy in preeclampsia. In this case-control study, the serum C-reactive protein (CRP) and AHSG levels were measured in 93 preeclamptic patients and in 127 healthy pregnant women by immunoturbidimetry and radial immunodiffusion. The serum CRP levels were significantly higher, whereas the serum AHSG concentrations were significantly lower in the preeclamptic group than in the control group (median (25th to 75th percentile), CRP: 6.71 mg l À1 (2.76-12.69) vs. 3.38 mg l À1 (1.69-7.27), respectively; AHSG: 660 lg ml À1 (612-768) vs. 744 lg ml À1 (660-816), respectively; Po0.001 for both). In preeclamptic patients, the serum AHSG concentrations showed significant inverse correlations with systolic blood pressure and serum CRP levels. A low serum AHSG level (p720 lg ml À1 ) was significantly associated with preeclampsia (adjusted odds ratio (95% confidence interval): 3.69 (1.82-7.51); Po0.001). According to the receiver operating characteristic curves, the measurement of serum AHSG concentrations was as accurate as that of serum CRP levels to detect preeclampsia. In conclusion, serum AHSG concentration is decreased and reflects-at least partly-systemic inflammation in preeclampsia.

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“…Számos májbetegségben (krónikus hepatitis, alkoholos és primer biliaris cirrhosis, primer hepatocellularis carcinoma) szintje markáns csökkenést mutat. Vizsgálata hasznosnak bizonyult ezen betegségekben [2,3]. Szerepet játszik a megfelelő csontfejlődésben, az idegrendszer érésében, egyes központi idegrendszeri betegségekben (sclerosis multiplex, Alzheimer-kór), illetve bizonyos daganatok kialakulásában is…”

Section: The Role Of Fetuin-a In Cardiovascular Diseasesunclassified

The role of fetuin-A in cardiovascular diseases

2014

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A máj által termelt fetuin-A (eredeti nevén α 2 -Heremans-Schmid-glikoprotein) szerteágazó funkciókkal bíró molekula. Bár negatív akutfázis-fehérje, szerepe a szubklinikus gyulladásban vitatott. Gátolja az inzulinreceptor autofoszforilációját, szérumkoncentrációja korrelál az inzulinrezisztenciával. A zsírsejtek működészavarát okozza. Szérum-szintje összefügg az elhízással és a nem alkoholos zsírmájbetegséggel. Bár ezen tulajdonságai alapján azt várnánk, hogy az atherosclerosis progresszióját segíti, cardiovascularis betegségekben játszott szerepe ennél összetettebb. A fetuin-A a szöveti és a vascularis kalcifi káció természetes gátlómolekulájaként az atherosclerosisban védő szerepet tölt be. A szerzők a fetuin-A artériakalcifi kációban és cardiovascularis betegségekben betöltött szerepét és prognosztikai értékét tekintik át, kitérve az ellentmondásosnak tűnő irodalmi eredmények magyarázatára és a lehetséges jövő-beni kutatási irányokra is. Orv. Hetil., 2014, 155(1), 16-23.Kulcsszavak: fetuin-A, inzulinrezisztencia, adipocytadiszfunkció, artériakalcifi káció, cardiovascularis betegségek The role of fetuin-A in cardiovascular diseasesFetuin-A (also known as α 2 -Heremans-Schmid glycoprotein) is a multifunctional molecule secreted by the liver. It is a negative acute phase reactant with a debated role in subclinical infl ammation. Fetuin-A is an inhibitor of the insulin receptor and its serum level correlates with insulin resistance. The protein has been implicated in adipocyte dysfunction and it is associated with obesity and non-alcoholic fatty liver disease. Although all these properties seem to promote atherosclerosis, the role of fetuin-A in cardiovascular diseases is more complex. As a natural inhibitor of tissue and vascular calcifi cation, fetuin-A also acts as a protective factor in atherosclerosis. The potential role and prognostic value of fetuin-A in arterial calcifi cation and cardiovascular diseases is discussed in this review, along with explanations for seemingly contradicting results in the literature and possible directions for future research. Rövidítések CAC = coronariakalcifi káció; CAD = coronaria-artéria betegség; CIMT = carotis intima-media vastagság; CKD = krónikus veseelégtelenség; CRP = C-reaktív protein; CVD = cardiovascularis betegség; FFA = szabad zsírsav; GGT = gamma-glutamiltranszferáz; HbA 1c = glikolizált hemoglobin-A-1c; HOMA = (homeostatic model assessment) inzulinrezisztencia-mérési modell; IFG = emelkedett éhomi vércukorszint; IGT = csök-kent glükóztolerancia; NAFLD = nem alkoholos eredetű zsírmáj; PAD = perifériás érbetegség; PPAR-γ = peroxiszóma-proliferátor-aktivált receptor-γ; T2DM = 2-es típusú diabetes mellitus; TNF-α = tumornekrózis-faktor-α A fetuin-A a plazmában magas koncentrációban megtalálható glikoprotein, amely a 3. kromoszómán található ahsg gén terméke [1]. A születést követően kizárólag a májban termelődik. Számos májbetegségben (krónikus hepatitis, alkoholos és primer biliaris cirrhosis, primer hepatocellularis carcinoma) szintje markáns csökkenést mutat. Viz...

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Decreased serum alfa2-HS-glycoprotein concentration in patients with primary biliary cirrhosis

Cited by 14 publications

References 5 publications

Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature

Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature

Preeclampsia is associated with decreased serum α2-HS glycoprotein (fetuin-A) concentration

The role of fetuin-A in cardiovascular diseases

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