Decreased Serum 1,5-Anhydroglucitol in Nondiabetic Subjects With a Family History of NIDDM

Tsukui, Satoshi; Fukumura, Yukihito; Kobayashi, Isao

doi:10.2337/diacare.19.9.940

Cited by 8 publications

(4 citation statements)

References 17 publications

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“…proved that, compared with HbA 1c and GA, 1,5‐AG was more strongly correlated with intraday blood glucose excursions, as indicated by the mean and largest amplitude of glycaemic excursions, standard deviation of blood glucose, postprandial glucose excursions, and postprandial incremental area under the curve. Japanese researchers compared serum 1,5‐AG levels, HbA 1c , PG 0 , PG 120 and urinary glucose concentrations between normal glucose tolerance individuals with ( n = 30) and without ( n = 228) a family history of diabetes, and observed that in participants with a positive family history, only serum 1,5‐AG levels were decreased, whereas the other available parameters, including HbA 1c , remained as normal as those without a family history of diabetes . Consistent with these findings, this study was conducted in a Chinese population classified as having normal glucose tolerance based on an OGTT, and revealed that there was a decrease in serum 1,5‐AG levels but no differences in HbA 1c or GA levels among FDR.…”

Section: Discussionsupporting

confidence: 66%

A decrease in serum 1,5‐anhydroglucitol levels is associated with the presence of a first‐degree family history of diabetes in a Chinese population with normal glucose tolerance

et al. 2017

Diabet. Med.

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Aim This study aimed to investigate alterations in HbA 1c , glycated albumin (GA) and 1,5-anhydroglucitol (1,5-AG) in Chinese first-degree relatives of individuals with diabetes (FDR) in pursuit of an index for early screening of glucose metabolism disturbance.Methods A total of 467 participants (age range: 20-78 years) with normal weight and normal glucose tolerance, as determined by a 75-g oral glucose tolerance test, were enrolled. HbA 1c was measured using high-performance liquid chromatography. Serum GA and 1,5-AG levels were determined by enzymatic methods. Serum insulin levels were measured using an electrochemiluminescence immunoassay.Results The study population included 208 FDR and 259 non-FDR. Serum 1,5-AG levels were lower in FDR than that in non-FDR (20.4 AE 7.5 vs 23.8 AE 8.3 lg/ml, P < 0.001), but HbA 1c and GA levels did not differ between them (P = 0.835 and 0.469, respectively). Logistic regression analysis revealed an independent relationship between a firstdegree family history of diabetes and reduced serum 1,5-AG levels (odds ratio = 0.944, P < 0.001). Multiple regression analysis showed that a first-degree family history of diabetes (b = -3.041, P < 0.001) and insulinogenic index (b = 0.081, P = 0.001) were independently associated with serum 1,5-AG levels. ConclusionIn a Chinese population with normal glucose tolerance, serum 1,5-AG levels were lower among FDR, and serum 1,5-AG levels were independently associated with FDR status. For FDR, serum 1,5-AG levels were more sensitive than HbA 1c or GA levels to early-phase abnormality in glucose metabolism. Diabet. Med. 35, 131-136 (2018)

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Section: Discussionsupporting

confidence: 66%

A decrease in serum 1,5‐anhydroglucitol levels is associated with the presence of a first‐degree family history of diabetes in a Chinese population with normal glucose tolerance

et al. 2017

Diabet. Med.

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“…Thus measurement of 1,5-AG may be a valid way to monitor slight changes in glycaemia in subjects with IGT. Tsukui et al [20] have reported that serum 1,5-AG was lower in nondiabetic subjects with a family history of Type II diabetes mellitus than in those with no family history, suggesting that 1,5-AG better reflects early glycaemic changes in these subjects than does HbA1c.…”

Section: Introductionmentioning

confidence: 96%

Post-load glucose measurements in oral glucose tolerance tests correlate well with 1,5-anhydroglucitol, an indicator of overall glycaemic state, in subjects with impaired glucose tolerance

Yamanouchi¹,

INOUE²,

OGATA³

et al. 2001

Clinical Science

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Using both cross-sectional and longitudinal methods, we investigated the relationship between post-load serum glucose concentration in a 75 g oral glucose tolerance test (OGTT) and overall glycaemic state in subjects with impaired glucose tolerance (IGT). Glycaemic state was assessed by measuring glycated haemoglobin (HbA1c) and the serum concentration of 1,5-anhydroglucitol (1,5-AG). In the cross-sectional study, the concentration of 1,5-AG, while remaining within a normal range, was reduced to a degree proportional to the post-load glycaemic level. Although the correlation between HbA1c and post-load plasma glucose was relatively weak (r=0.281, P<0.001), a significant inverse correlation (r=-0.824, P<0.0001) was found between 1,5-AG and mean post-load plasma glucose concentration in 211 subjects with IGT. Fasting plasma glucose (r=-0.539, P<0.0001) and 2 h plasma glucose (r=-0.621, P<0.0001) were correlated with 1,5-AG less strongly than was post-load glycaemia. Both 1,5-AG and HbA1c were correlated weakly but significantly with the fasting insulin concentration. In the longitudinal study we measured 1,5-AG and mean post-load plasma glucose with an OGTT once yearly for 10 years in 15 subjects with IGT. Strong inverse correlations were seen between 1,5-AG and mean post-load plasma glucose in each subject (range of r values among subjects of -0.584 to -0.978). These findings suggest a close relationship between post-load plasma glucose concentration measured by OGTT and overall glycaemic state in subjects with IGT.

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“…This may imply that 1,5-AG better reflects glycemic changes of prediabetes than HbA1c. It was previously reported that serum 1,5-AG concentrations were lower in nondiabetic subjects with a family history of T2DM than in those with no family history 38) . The level of 1,5-AG, while maintained within the normal range, was decreased in IGT subjects 39) .…”

Section: Discussionmentioning

confidence: 85%

Value of serum 1,5-anhydroglucitol measurements in childhood obesity in the continuum of diabetes

Yoo

Kwak

Son

et al. 2015

Ann Pediatr Endocrinol Metab

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PurposeThe prevalence of type 2 diabetes mellitus (T2DM) and obesity are currently increasing. Accordingly, the concept of "preventing diabetes" in high-risk groups has become more important in diabetic care, but the use of glycated hemoglobin (HbA1c) as a measure has limitations in this field. The aim of this study was to investigate the utility of 1,5-anhydroglucitol (1,5-AG) in assessing prediabetes status in obese children.MethodsThe medical records of 74 subjects aged 6-19 years (of which 27 were overweight/obese and 47 had diabetes) who had 1,5-AG data were reviewed retrospectively. We compared 1,5-AG with HbA1c using the Pearson correlation test to assess the clinical utility of 1,5-AG.Results1,5-AG levels were higher (31.1±10.1 µg/mL vs. 7.4±7.3 µg/mL) and HbA1c levels were lower (5.5%±0.3% vs. 8.9%±2.7%) in the overweight/obese group than in the diabetics group. The range of 1,5-AG levels in obese children was wide (16.8-59.3 µg/mL), and did not have significance with HbA1c. A negative correlation between 1,5-AG and HbA1c was significant in the entire subject (r=-0.822, P<0.001), and also in the HbA1c range of 5.5% to 8% (r=-0.736, P<0.001).Conclusion1,5-AG is a valuable index in the HbA1c range of 5.5%-8% and it might be considered an early glycemic control index in insulin-resistant obese children with an HbA1c level above 5.5%. Moreover, the 1,5-AG level assessment should be presented as a supplementary tool for better compliance, as well as being an improvement in diabetes management for the short-term glucose control in relatively well-controlled diabetes patients with an HbA1c level below 8%.

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Decreased Serum 1,5-Anhydroglucitol in Nondiabetic Subjects With a Family History of NIDDM

Abstract: Serum AG is related to glycosuria even among nondiabetic subjects, and its concentrations are decreased in those with a family history of NIDDM. Our results suggest that serum AG rather than HbAlc reflects early metabolic abnormalities in these subjects.

Cited by 8 publications

References 17 publications

A decrease in serum 1,5‐anhydroglucitol levels is associated with the presence of a first‐degree family history of diabetes in a Chinese population with normal glucose tolerance

A decrease in serum 1,5‐anhydroglucitol levels is associated with the presence of a first‐degree family history of diabetes in a Chinese population with normal glucose tolerance

Post-load glucose measurements in oral glucose tolerance tests correlate well with 1,5-anhydroglucitol, an indicator of overall glycaemic state, in subjects with impaired glucose tolerance

Value of serum 1,5-anhydroglucitol measurements in childhood obesity in the continuum of diabetes

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