Decreased regional homogeneity and increased functional connectivity of default network correlated with neurocognitive deficits in subjects with genetic high-risk for schizophrenia: A resting-state fMRI study

Ma, Xiaoqian; Zheng, Wenxiao; Li, Chunwang; Li, Zongchang; Tang, Jinsong; Liu, Yuan; Ouyang, Lijun; Jin, Ke; Hé, Ying; Chen, Xiaogang

doi:10.1016/j.psychres.2019.112603

Cited by 28 publications

(12 citation statements)

References 59 publications

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“…These metrics delineate brain functional properties from distinct perspectives. They have been frequently used to study brain functional abnormalities in various neuropsychiatric disorders ( Zang et al, 2007 ; Wu et al, 2009 ; Hoptman et al, 2010 ; Paakki et al, 2010 ; Liang et al, 2011 ; Premi et al, 2014 ; Dai et al, 2015 ; Ma et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

The Effects of rs405509 on APOEε4 Non-carriers in Non-demented Aging

Zhao

et al. 2021

Front. Neurosci.

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BackgroundThere is evidence that the T allele of rs405509 located in the apolipoprotein E (APOE) promotor region is a risk factor for Alzheimer’s disease (AD). However, the effect of the T/T allele on brain function in non-demented aging is still unclear.MethodsWe analyzed the effects of the rs405509 T/T allele on cognitive performances using multiple neuropsychological tests and local brain function using resting-state functional magnetic resonance imaging (rs-fMRI).ResultsSignificant differences were found between T/T carriers and G allele carriers on general cognitive status, memory, and attention (p < 0.05). Rs-fMRI analyses demonstrated decreased amplitude of low frequency fluctuation (ALFF) in the right middle frontal gyrus, decreased percent amplitude of fluctuation (PerAF) in the right middle frontal gyrus, increased regional homogeneity (ReHo) in the right cerebellar tonsil and decreased ReHo in the right putamen, and decreased degree centrality (DC) in the left middle frontal gyrus (p < 0.05, corrected). Furthermore, significant correlations were found between cognitive performance and these neuroimaging changes (p < 0.05).ConclusionThese findings suggest that T/T allele may serve as an independent risk factor that can influence brain function in different regions in non-demented aging.

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Section: Introductionmentioning

confidence: 99%

The Effects of rs405509 on APOEε4 Non-carriers in Non-demented Aging

Zhao

et al. 2021

Front. Neurosci.

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“…Schizophrenia is a complex condition associated with cognitive impairments [37,38], and is increasingly becoming more prevalent with its burden more and more heavy in China [39,40] and the world [41]. Its etiopathogenesis is still unclear and the underlying molecular mechanisms remain unknown, making its treatment and preventive measures very limited, imposing a heavy burden on patients and their families.…”

Section: Discussionmentioning

confidence: 99%

ω-3PUFAs Improve Cognitive Impairments Through Ser133 Phosphorylation of CREB Upregulating BDNF/TrkB Signal in Schizophrenia

Guo

Liu

Fang³

et al. 2020

Neurotherapeutics

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Schizophrenia (SZ) is a serious mental condition and is associated with cognitive impairments. Brain-derived neurotrophic factor (BDNF) is one of the learning-and memory-related molecules found in the CNS and its level was reported to be reduced in SZ brain, while ω-3 polyunsaturated fatty acids (ω-3PUFAs) could improve SZ symptoms, but its mechanism of action remains unknown. Using MK801 injection-induced SZ rat model, we here found that supplementation with ω-3PUFAs improved the levels of p-CREB, BDNF, and p-TrkB in the brain of SZ rats, and restore hippocampal neuronal damage, thereby reducing cognitive impairments in SZ rats. However, overexpression of AAV9/CREB S133A (CREB inactivated mutation) downregulated BDNF/TrkB signaling pathway and remarkably abolished the preventive effect of ω-3PUFAs in MK801-induced schizophrenia. Interestingly, AAV9/CREB S133D (CREB activated mutation) improved synaptic dysfunctions and cognitive defects in MK801 rats. In conclusion, these findings indicate that MK801-induced SZ lesions dephosphorylate CREB at Ser133 site, leading to neuron damage, and ω-3PUFAs improve SZ cognitive impairments by upregulating the CREB/BDNF/TrkB pathway, which provides new clues for the mechanism of SZ cognitive impairments, and a basis for therapeutic intervention.

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“…The DMN is abnormal in schizophrenia [38][39][40], and abnormalities in parts of the DMN are related to symptoms [41] and deficits [39] in the disorder. As with FA, RSFC abnormalities are seen in first episode schizophrenia [42][43][44] and those at risk [45]. They also show heritability [46].…”

Section: Introductionmentioning

confidence: 92%

Relationships between Diffusion Tensor Imaging and Resting State Functional Connectivity in Patients with Schizophrenia and Healthy Controls: A Preliminary Study

Hoptman¹,

Tural²,

Lim³

et al. 2021

Preprint

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Schizophrenia is widely seen as a disorder of dysconnectivity. Neuroimaging studies have examined both structural and functional connectivity in the disorder, but these modalities have rarely been integrated directly. We scanned 29 patients with schizophrenia and 25 healthy control subjects and acquired resting state fMRI and diffusion tensor imaging. The Functional and Tractographic Connectivity Analysis Toolbox (FATCAT) was used to estimate functional and structural connectivity of the default mode network. Correlations between modalities were investigated, and multimodal connectivity scores (MCS) were created using principal components analysis. Nine of 28 possible region pairs showed consistent (>80%) tracts across participants. Correlations between modalities were found among those with schizophrenia for the prefrontal cortex, posterior cingulate, and lateral temporal lobes with frontal and parietal regions, consistent with frontotemporoparietal network involvement in the disorder. In patients, MCS values correlated with several aspects of the Positive and Negative Syndrome Scale, positively with those involving inwardly directed psychopathology, and negatively with those involving external psychopathology. In this preliminary sample, we found FATCAT to be a useful toolbox to directly integrate and examine connectivity between imaging modalities. A consideration of conjoint structural and functional connectivity can provide important information about the network mechanisms of schizophrenia.

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Decreased regional homogeneity and increased functional connectivity of default network correlated with neurocognitive deficits in subjects with genetic high-risk for schizophrenia: A resting-state fMRI study

Cited by 28 publications

References 59 publications

The Effects of rs405509 on APOEε4 Non-carriers in Non-demented Aging

The Effects of rs405509 on APOEε4 Non-carriers in Non-demented Aging

ω-3PUFAs Improve Cognitive Impairments Through Ser133 Phosphorylation of CREB Upregulating BDNF/TrkB Signal in Schizophrenia

Relationships between Diffusion Tensor Imaging and Resting State Functional Connectivity in Patients with Schizophrenia and Healthy Controls: A Preliminary Study

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