Decreased ratio of high-molecular-weight to total adiponectin is associated with angiographic coronary atherosclerosis severity but not restenosis

Liang, Kae‐Woei; Lee, Wen‐Jane; Lee, Wen-Lieng; Ting, Chih‐Tai; Sheu, Wayne Huey‐Herng

doi:10.1016/j.cca.2009.04.018

Cited by 24 publications

(15 citation statements)

References 30 publications

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“…Although HMW adiponectin is not necessarily related to present macrovascular disease and does not predict cardiovascular events in patients with diabetes mellitus type 2 [24], HMW adiponectin and its ratio to total adiponectin have been judged as more valuable biomarkers for CAD than total adiponectin [25,26]. Thus, we determined serum HMW adiponectin in a subgroup of patients to support our findings.…”

Section: Discussionsupporting

confidence: 74%

High plasma levels of adipocytokines are associated with platelet activation in patients with coronary artery disease

et al. 2009

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Previous studies suggested that the adipocytokines, adiponectin and leptin, are associated with the progression and prognosis of coronary artery disease (CAD). The aim of this study was to differentially evaluate plasma levels of adiponectin and leptin in patients with CAD and their association with conventional laboratory parameters and markers of platelet activation. We consecutively evaluated 220 patients, who presented with a symptomatic CAD. Among these 83 (37.7%) presented with an acute coronary syndrome (ACS) and 137 (62.3%) with a stable angina pectoris (SAP). All patients have received coronary angiography. Baseline concentrations were determined by enzyme-linked immunosorbent assay (ELISA). Lower detection limits of the assay were 0.079 ng/mL for total adiponectin and 15.6 pg/mL for leptin. Patients with ACS showed significantly enhanced plasma levels of adiponectin and leptin compared with SAP (ACS vs. SAP (mean +/- SD): adiponectin: 9.9 +/- 7.6 microg/mL vs. 7.2 +/- 5.7 microg/mL; P = 0.008; leptin: 20.9 +/- 16.4 ng/mL vs. 15.2 +/- 10.9 ng/mL; P = 0.012). However, a correlation between plasma total adiponectin and leptin levels has not been observed (r = 0.038; P = 0.706). Plasma levels of total adiponectin and leptin positively correlated with C-reactive protein (adiponectin: r = 0.277; P = 0.001; leptin: r = 0.248; P = 0.007) and troponin-I (adiponectin: r = 0.219; P = 0.001; leptin: r = 0.190; P = 0.025). Plasma levels of both adipocytokines have shown an inverse correlation with markers of platelet activation such as platelet glycoprotein VI (adiponectin: r = -0.120; P = 0.048; leptin:r = -0.205; P = 0.036), and in a negative trend with P-selectin (adiponectin: r = -0.116; P = 0.073; leptin: r = -0.172; P = 0.078). To support our findings, we determined high-molecular-weight adiponectin in a subgroup of 37 patients, which showed similar results. Increased concentrations of total adiponectin and leptin were associated with ACS. Intriguingly, high plasma levels of both adipocytokines seem to modulate platelet activation. Further studies should elucidate the adipocytokine regulation in CAD.

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Section: Discussionsupporting

confidence: 74%

High plasma levels of adipocytokines are associated with platelet activation in patients with coronary artery disease

et al. 2009

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“…4-7 These individuals have been labeled the “metabolically healthy obese phenotype”. One factor associated with the healthy obese phenotype is adiponectin,8 a protein with a high-molecular-weight (HMW) multimer structure in the blood, 9, 10 secreted by adipose tissue, having insulin sensitizing and anti-inflammatory effects and increasing HDLC. Martin et al 11 reported that adiponectin’s relationship with HDLC and triglycerides was present in lean adolescents, but strengthened with increasing adiposity.…”

Section: Introductionmentioning

confidence: 99%

Paradoxically high adiponectin and the healthy obese phenotype in obese black and white 16-year-old girls

Morrison

Glueck

Daniels

et al. 2010

Translational Research

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Although adiponectin is inversely correlated with obesity, some obese adults without metabolic complications of obesity have paradoxically high adiponectin. Therefore, we assessed adiponectin-risk factor relations in 133 obese 16-year-old schoolgirls from a cohort of 448, focusing on paradoxically high adiponectin in obesity and the healthy obese phenotype. Median adiponectin (11.9 mg/L) in non-obese girls (BMI <24.6 kg/m2) was selected as a cutpoint to identify high adiponectin in obese girls. Of 90 black and 43 white obese girls (BMI ≥ 24.6), 25 black (28%) and 13 white (30%) girls had paradoxically high adiponectin (>11.9). The 38 obese girls with adiponectin >11.9 vs the 95 obese girls with adiponectin ≤ 11.9 had higher median HDL cholesterol (54 vs 46 mg/dl, p=.0007) and ApoA1 (181 vs 164 mg/dl, p=.011), and lower insulin (14 vs 20 uU/ml, p=.0006). In the 133 obese girls, by stepwise regression, adiponectin category (>11.9, ≤ 11.9 mg/L) was a significant independent positive determinant of HDL cholesterol (partial R2 = 8.4%, p =.001), and apolipoprotein A1 (partial R2 = 4.1%, p =.025), and was inversely associated with fasting serum insulin (partial R2 = 5.4%, p =.0074). By stepwise logistic regression in the 133 obese girls, adiponectin category (high vs. low) was a significant inverse explanatory variable for metabolic syndrome, odds ratio 0.20, 95% confidence intervals 0.04-0.95, p=.043. We conclude that paradoxically high adiponectin is associated with the healthy obese phenotype in obese adolescent black and white girls.

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“…The healthy obese phenotype is strongly related to paradoxically high adiponectin levels above the median for non-obese subjects, despite adiponectin’s inverse correlation with BMI in general (11–13). Adiponectin is a protein with a high-molecular-weight multimer structure in the blood, (14, 15) secreted by adipose tissue. Adiponectin has insulin-sensitizing and anti-inflammatory effects, and increases HDLC (16) (17).…”

mentioning

confidence: 99%

Paradoxically High Adiponectin in Obese 16-Year-Old Girls Protects Against Appearance of the Metabolic Syndrome and its Components Seven Years Later

Morrison

Glueck

Daniels

et al. 2011

The Journal of Pediatrics

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Objective-To evaluate the relationships of adiponectin levels at age 16 years in obese schoolgirls to metabolic syndrome and its components at age 23 years. Study design-Seven year prospective study of 381 females.Results-In 144 white and 129 black non-obese 16-year old girls (BMI <24.6 kg/m 2 ), racespecific median adiponectin levels (white 12 mg/L, black 11) was used to identify paradoxically high adiponectin levels in obese girls. Of 34 white and 74 black obese girls, 12 (35%) and 19 (26%) had paradoxically high adiponectin levels. In these 108 obese girls, adiponectin levels at age 16 years independently predicted HDLC (positive) and waist (negative), insulin (negative), and glucose (negative) at age 23 years; paradoxically high adiponectin levels at age 16 years was a negative independent predictor for waist, HOMA IR, and for the number of abnormal components of the metabolic syndrome at age 23 years. In 31 pairs of obese girls with and without paradoxically high adiponectin levels, matched by race and age 16 BMI, adiponectin levels at age 16 years was a negative predictor for the number of abnormal metabolic syndrome components at age 23 years.Conclusion-Paradoxically high adiponectin levels in obese 16 year old girls protects against metabolic syndrome and its components at age 23 years.The role of obesity in the pathogenesis of cardiovascular disease (CVD) is largely mediated through its effects on components of the metabolic syndrome, high triglycerides [TG], systolic and diastolic blood pressure [SBP, DBP], insulin, glucose, and low HDL-cholesterol [HDLC] (1,2). Childhood metabolic syndrome and its separate components are associated with type 2 diabetes in young adulthood (3,4). Centripetal obesity remains as a significant residual risk factor for CVD, even after adjusting for the Framingham Risk Factor score (5).Address correspondence to Charles J. Glueck MD, Cholesterol Center, ABC Building, 3200 Burnet Avenue, Cincinnati OH, 45229; phone 513-585-7945; fax 513-585-7950; glueckch@healthall.com;. The authors declare no conflicts of interest.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. In the Class III obesity range, defined as a body mass index (BMI) ≥40 kg/m 2 , some 20% of adults are largely free (6) of the metabolic complications of obesity (low HDLC, high insulin, TG, glucose, SBP, and DBP) (7-10), having the "metabolically healthy obese phenotype" (11). The healthy obese phenotype is strongly related to paradoxically high adiponectin levels above the median for non-obese subjects, despite adiponectin's inverse correlation with BMI in general (11...

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Decreased ratio of high-molecular-weight to total adiponectin is associated with angiographic coronary atherosclerosis severity but not restenosis

Cited by 24 publications

References 30 publications

High plasma levels of adipocytokines are associated with platelet activation in patients with coronary artery disease

High plasma levels of adipocytokines are associated with platelet activation in patients with coronary artery disease

Paradoxically high adiponectin and the healthy obese phenotype in obese black and white 16-year-old girls

Paradoxically High Adiponectin in Obese 16-Year-Old Girls Protects Against Appearance of the Metabolic Syndrome and its Components Seven Years Later

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