Decreased prolactin response to hypoglycaemia in patients with rheumatoid arthritis: correlation with disease activity

Eijsbouts, A.M.M.; Hoogen, F.H.J. van den; Laan, R.F.J.M.; Sweep, Fred C.G.J.; Hermus, A.R.M.M.; Putte, L.B.A. van de

doi:10.1136/ard.2002.001347

Cited by 16 publications

(8 citation statements)

References 22 publications

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“…Similarly, we found no differences in serum PRL levels in PsA patients with or without treatment by Disease-Modifying antirheumatic drugs (DMARDs). No role of DMARDs in serum basal PRL levels in RA was found in the Eijsbouts study -20 RA patients were treated by sulfasalazine or methotrexate (MTX) for 6 months and there were no changes in basal PRL levels after 2 weeks and 6 months 39 . Rovensky et al analysed the response to hypoglycaemia in patients suffering from RA and ankylosing spondylitis (AS) (ref.…”

Section: Discussionmentioning

confidence: 97%

Elevated serum prolactin levels as a marker of inflammatory arthritis in psoriasis vulgaris

Hušáková¹,

Lippert²,

Štolfa³

et al. 2015

BIOMED PAP

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a Background and Aims. Psoriasis vulgaris (PV) is complicated in up to 40% patients by the inflammatory joint disease psoriatic arthritis (PsA). Neither the aetiology of the arthritis nor specific laboratory markers for its disease activity have been clearly elucidated. Prolactin (PRL) acts as a cytokine with immunomodulatory functions and plays a role in skin and joint biology. The results on PRL however as a marker are unclear. The aim of this study was to confirm whether serum PRL levels reflect systemic complications of PV, like inflammatory joint disease and/or can serve as a marker of disease activity in both cases. Methods. A total of 70 patients with PV without arthritis and 40 patients suffering from PsA were included. In all patients, we determined skin disease activity according to the PASI index and in PsA, active disease assessed as swollen or tender joints. The control group included 27 age and sex matched healthy individuals. The concentration of PRL in the serum was measured by immunoradiometric assays. Results. The PRL serum levels were significantly increased in PsA patients (299.2±28.29 mIU/L) compared to PV only patients (201.4.2±11.72 mIU/L), P = 0.0003 and healthy individuals (198.2±15.31 mIU/L), P = 0.007. The serum PRL levels in PsA with active disease 336.8±42.50 (mIU/L) were higher than in PV and controls, P < 0.0001 and P = 0.002 respectively. In PV only patients, there was no correlation between PASI and PRL levels. Conclusion. Our results showed that PRL serum levels are a marker of active arthritis in PsA and reflects systemic complication rather than local skin activity.

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Section: Discussionmentioning

confidence: 97%

Elevated serum prolactin levels as a marker of inflammatory arthritis in psoriasis vulgaris

Hušáková¹,

Lippert²,

Štolfa³

et al. 2015

BIOMED PAP

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“…The PRL response to acute stressors of patients with RA was observed to be normal, 24 increased, 17 and attenuated. 23,69 The health consequences of acute time-limited stressors are unclear. A recent study suggested that even acute mental stressors are able to increase C-reactive protein (CRP), and more specifically in those patients with high disease activity.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Stressors on Health Status and Hypothalamic‐Pituitary‐Adrenal Axis and Autonomic Nervous System Responsiveness in Rheumatoid Arthritis

Geenen

Middendorp

Bijlsma

2006

Annals of the New York Academy of Sciences

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The hypothalamic-pituitary-adrenal (HPA) axis and the autonomic nervous system (ANS) are critically involved in inflammation and are activated by stress. This suggests that stressful circumstances may affect the chronic inflammation of rheumatoid arthritis (RA). Fifty-six scientific publications of the past 15 years were reviewed to get insight into the possible impact of stressors (grouped in five categories) on the health status and HPA axis and ANS functioning of adult patients with RA. Our findings in this review were: (1) In response to mental and physical effort and applied physiological stressors, patients demonstrate ANS hyporesponsiveness and "too normal" HPA axis responsiveness considering the elevated immune activity. A premorbid defect, past and current inflammatory activity, past and current stress, and physical deconditioning may explain disturbed physiological responses. (2) After brief naturalistic stressors, self-perceived and clinician's ratings of disease activity are increased; inflammation parameters have been insufficiently examined. (3) Major life events do not univocally affect disease status, but appear able to modify disease activity in a positive or negative way, depending on the nature, duration, and dose of the accompanying physiological stress response. (4) Enduring (e.g., work-related or interpersonal) stressors are associated with perceived health. Because this stressor category mingles with personality variables, the mere observation of a correlation does not prove that chronic stressors provoke health changes, although this might be the case. (5) Not one study rigorously examined the prospective hypothesis that past stressors (e.g., childhood victimization or pre-onset stressful incidents) may trigger RA or aggravate existing RA, which is a realistic belief for some patients.

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“…Nevertheless, patients with active RA have a decreased PRL response to hypoglycemia-induced stress. The response recovers after 6 months of treatment with antirheumatic drugs, although one third of RA patients may have a tendency towards a higher threshold for PRL release in response to hypoglycemia, which deserves further investigation [53,54]. A study displayed that T cells and fibroblasts of patients with RA could produce PRL, and BRC reduced its production in those cells.…”

Section: Prolactin and Rheumatoid Arthritismentioning

confidence: 98%

Prolactin and Autoimmunity

Jara

Medina

Saavedra

et al. 2009

Clinic Rev Allerg Immunol

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The relationship between prolactin and the immune system has been demonstrated in the last two decades, opening new windows in the field of the immunoendocrinology. Prolactin has an important role in the innate and adaptive immune response. Increased prolactin levels have been described in autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, Sjögren syndrome, and systemic sclerosis among others. Hyperprolactinemia is associated with active disease and organ involvement in systemic lupus erythematosus. Therefore, prolactin is an integral member of the immunoneuroendocrinology network and seems to have a role in pathogenesis of autoimmune diseases. Few controlled studies of dopamine agonist treatment in humans with autoimmune disease have been conducted only in systemic lupus erythematosus patients, which support the potential efficacy of such agents even during pregnancy and postpartum. Further studies are necessary to elucidate the mechanisms by which prolactin affects autoimmune disease activity, increase the inflammatory mechanism, and determine the role of anti-prolactinemic drugs to regulate the immune/inflammatory process.

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Decreased prolactin response to hypoglycaemia in patients with rheumatoid arthritis: correlation with disease activity

Cited by 16 publications

References 22 publications

Elevated serum prolactin levels as a marker of inflammatory arthritis in psoriasis vulgaris

Elevated serum prolactin levels as a marker of inflammatory arthritis in psoriasis vulgaris

The Impact of Stressors on Health Status and Hypothalamic‐Pituitary‐Adrenal Axis and Autonomic Nervous System Responsiveness in Rheumatoid Arthritis

Prolactin and Autoimmunity

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