2010
DOI: 10.1590/s0074-02762010000300004
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Decreased production of TNF-alpha by lymph node cells indicates experimental autoimmune encephalomyelitis remission in Lewis rats

Abstract: Experimental autoimmune encephalomyelitis (EAE) is mediated by CD4 + Th1 cells that mainly secrete IFN-γ and TNF-α, important

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Cited by 13 publications
(8 citation statements)
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References 38 publications
(35 reference statements)
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“…At 7 days post immunization (dpi), immunized rats started to exhibit clinical symptoms of EAE including the loss of tail tonicity, abnormal gait, and continuous progression of disease. At around 15 to 18 dpi, animals showed scoring up to grade 4 and exhibited features such as hind leg paralysis and hind body paralysis with physical symptoms of reddish and swollen hind feet [ 33 ] ( Fig 3A ).…”
Section: Resultsmentioning
confidence: 99%
“…At 7 days post immunization (dpi), immunized rats started to exhibit clinical symptoms of EAE including the loss of tail tonicity, abnormal gait, and continuous progression of disease. At around 15 to 18 dpi, animals showed scoring up to grade 4 and exhibited features such as hind leg paralysis and hind body paralysis with physical symptoms of reddish and swollen hind feet [ 33 ] ( Fig 3A ).…”
Section: Resultsmentioning
confidence: 99%
“…Subsequent to the deficits observed during the initial acute attack, most of the animals recorded at the firstremission phase of EAE in our study demonstrated an increase in amplitude in both teriflunomide-treated groups. During the remission phase of EAE, it has been reported that numerous regenerative and cell repair processes occur after the proinflammatory phase of EAE, and these processes work to repair or enhance the survival of affected neurons (Zhu et al, 2003;Barbizan and Oliveira, 2010;Seger et al, 2010). However, in EAE vehicle-treated animals, we observed a reduction in amplitude at first relapse and then a more notable reduction during the relapse-remission phase of EAE disease; this time frame has been associated with increased axonal loss (Merrill et al, 2009).…”
Section: Effects Of Teriflunomide On Da Eae Rat Electrophysiology 207mentioning
confidence: 48%
“…[46][47][48] The significant point in the present study was the higher percentage of weight gain with the medium dose of MSc1 during the acute phase of disease compared to the control groups.…”
mentioning
confidence: 44%