2012
DOI: 10.1371/journal.pone.0042560
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Decreased Premotor Cortex Volume in Victims of Urban Violence with Posttraumatic Stress Disorder

Abstract: BackgroundStudies addressing posttraumatic stress disorder (PTSD) have demonstrated that PTSD patients exhibit structural abnormalities in brain regions that relate to stress regulation and fear responses, such as the hippocampus, amygdala, anterior cingulate cortex, and ventromedial prefrontal cortex. Premotor cortical areas are involved in preparing to respond to a threatening situation and in representing the peripersonal space. Urban violence is an important and pervasive cause of human suffering, especial… Show more

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Cited by 50 publications
(24 citation statements)
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“…The evidence for the involvement of specific neural structures in trauma-related psychopathology comes primarily from the study of PTSD, with most evidence suggesting a diminished hippocampus [25, 60, 61], smaller prefrontal structures [6264], and possibly an enlarged amygdala [65, 66]. However, recent findings suggest sex-related heterogeneity in all these structures.…”
Section: Direct Evidence Of Sex Differences In Trauma-related Psychopmentioning
confidence: 99%
“…The evidence for the involvement of specific neural structures in trauma-related psychopathology comes primarily from the study of PTSD, with most evidence suggesting a diminished hippocampus [25, 60, 61], smaller prefrontal structures [6264], and possibly an enlarged amygdala [65, 66]. However, recent findings suggest sex-related heterogeneity in all these structures.…”
Section: Direct Evidence Of Sex Differences In Trauma-related Psychopmentioning
confidence: 99%
“…Thus, verbal memory impairments are the most consistent finding in PTSD, particularly autobiographical memory [55]. Other studies have seen other structural changes with PTSD in the corpus callosum [51, 56], premotor cortex [57], and areas of the prefrontal cortex [54, 58, 59]. Notably, these are areas often affecting brain responses to food cues and influencing feeding behaviors.…”
mentioning
confidence: 99%
“…One of the best investigation results in the field of stress and trauma is the doseresponse relationship which is related to one of the laws of physics, and that means the higher the dose of trauma experience is the more possible disturbing the consequences, which might lead to severe psychiatric stress-related disorders and illnesses [2,3].…”
Section: Author Detailsmentioning
confidence: 99%