Decreased polyunsaturated and increased saturated fatty acid concentration in spermatozoa from asthenozoospermic males as compared with normozoospermic males

Tavilani, Heidar; Doosti, Mahmood; Abdi, Khosrou; Vaisi-Raygani, Asad; Joshaghani, Hamidreza

doi:10.1111/j.1439-0272.2006.00735.x

Cited by 99 publications

(79 citation statements)

References 25 publications

(31 reference statements)

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“…Lipid composition of spermatozoa and seminal fluids plays a significant role in male fertility (Tavilani et al 2006, Wathes et al 2007. In bovines, seasonal variations in total lipid and cholesterol concentrations in spermatozoa are associated with reduced sperm motility (Argov et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Season-induced variation in lipid composition is associated with semen quality in Holstein bulls

et al. 2013

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Season-induced variation in fatty acid and cholesterol composition in bovine semen has been associated with semen quality. Given the specific roles of the various semen compartments (seminal fluids, sperm head, and sperm tail) in fertilization, we hypothesized that environmental-stress-induced alterations in the lipid composition of a specific compartment might impair semen quality and sperm function. Semen samples were collected from five mature Holstein-Friesian bulls during the summer (August to September) and winter (December to January). Semen was evaluated by computerized sperm-quality analyzer, calibrated for bulls' semen, and centrifuged to separate the spermatozoa from the seminal fluids. The spermatozoal fraction was sonicated to separate the sperm head and tail compartments. Cold lipid extraction was performed with chloroform:methanol (2:1, vol/vol). Lipids were identified and quantified by gas chromatography. Seasonal variation was found in both physiological and structural parameters. The proportion of spermatozoa defined as morphologically normal was higher in the winter, with higher motility, progressive motility, and velocity relative to summer samples. Lipid composition within fractions varied between seasons with prominent impairment in the tail compartment, characterized by high saturated fatty acid, low polyunsaturated fatty acid, and low cholesterol concentrations during the summer. Given the association between alterations in lipid composition and reduced sperm motility and velocity during the summer, it is suggested that lipid composition might serve to predict sperm quality.

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Section: Discussionmentioning

confidence: 99%

Season-induced variation in lipid composition is associated with semen quality in Holstein bulls

et al. 2013

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“…3,4 The significant effects of dietary fatty acids (FAs) on male fertility have been well documented both in animal and human studies. 5,6 There are three types of natural FAs: saturated, monounsaturated and polyunsaturated. Polyunsaturated fatty acids (PUFAs) are essential FAs, because they cannot be synthesized by the human body.…”

mentioning

confidence: 99%

The roles of omega-3 and omega-6 fatty acids in idiopathic male infertility

Safarinejad¹,

Safarinejad²

2012

Asian J Androl

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mega-3 fatty acids found in some foods have a wide-range of health benefits. The omega-3 supplementation results in higher antioxidant activity in human seminal fluid and enhanced sperm count, sperm motility, and sperm morphology. Considerable number of infertile men with idiopathic oligoasthenoteratozoospermia might be benefit from omega-3 fatty acids administration.Infertility caused by idiopathic oligoasthenoteratozoospermia(OAT) syndrome without any female factor represents one of the biggest patients group in the daily practice of urologists. Despite great advances in the field of infertility, still many cases of male infertility are diagnosed as idiopathic and remained untreated. In low-income communities where health service resources are restricted and basic health needs are unmet, health resources are not used to provide expensive technologies for the treatment of infertility. Social and family consequences of infertility, especially in developing and under developed communities are devastating. A decrease in male fertility has been occurred over the years. 1 Sperm density had fallen by 40% over the past 50 years. 2 One of the reasons for the impaired semen parameters over the years is dietary factors. 3,4 The significant effects of dietary fatty acids (FAs) on male fertility have been well documented both in animal and human studies. 5,6 There are three types of natural FAs: saturated, monounsaturated and polyunsaturated. Polyunsaturated fatty acids (PUFAs) are essential FAs, because they cannot be synthesized by the human body. Docosahexanoic acid (DHA), eicosapentanoic acid (EPA) and alinolenic acid are the main omega-3 PUFAs.Linoleic acid, c-linolenic acid and arachidonic acid (AA) are the main omega-6 PUFAs. The first mechanism by which omega-3 and omega-6 PUFAs affect spermatogenesis, is by the incorporation into spermatozoa cell membrane. Omega-3 and omega-6 PUFAs are structural components of cell membranes. 7 The lipid bilayer of cellular membranes is maintained by the presence of these PUFAs. 8 The successful fertilization of spermatozoa depends on the lipids of the spermatozoa membrane. 9 Deleterious health effects of increased dietary omega-6/omega-3 ratios have been documented in many studies. 10 The ideal ratio is 1:1. During the past 100 years, omega-6 PUFAs of Western diets have increased dramatically. This has resulted in an omega-6/omega-3 ratio of 25:1 to 40:1. 11 Increased omega-6/omega-3 ratio in spermatozoa has also been implicated in impaired semen quality in oligozoospermic and/or asthenozoospermic men. 12 Spermatozoa from asthenozoospermic and oligozoospermic men exhibit decreased concentrations of DHA compared with those from normozoospermic men. Conquer et al. 13 demonstrated that, compared with normozoospermic men, spermatozoa from asthenozoospermic men have diminished concentrations of DHA and higher concentrations of oleic acid. Safarinejad et al., 14 investigated PUFA composition of the blood plasma and spermatozoa in men with idiopathic OAT. They found that, fertile men h...

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“…In a further study, fatty acid composition of spermatozoa of normozoospermic, asthenozoospermic, oligozoospermic and oligoasthenozoospermic men were analysed [19]. Spermatozoa from asthenozoospermic (P<0.01), oligozoospermic (P<0.05) and oligoasthenozoospermic men (P<0.05) had lower levels of docosahexaenoic acid (22:6w3, DHA) than those from normozoospermic men.…”

Section: Omega-6 and Omega-3 Fatty Acids In Infer-tilitymentioning

confidence: 99%

“…These receptors may be under the influence of various nutrients, vitamin A.E.C beta carotene, zinc, copper, selenium, calcium, magnesium, w-3 fatty acids and related enzymes. Composition of the egg's protective jelly-like protein coating and that of sperm membrane, in relation to the w-3 fatty acids, particularly w-6/w-3 ratio appear to be important in the mechanism of fertilization [15][16][17][18][19][20][21][22]. w-3 FA are essential polyunsaturated fatty acids (PUFAs) because it is necessary to acquire them through food consumption.…”

Section: Progesterone and Infertilitymentioning

confidence: 99%

“…Recently two independent research groups reported that progesterone potently activates CatSper, the principal Ca 2+ channel of the sperm flagellum which is important in fertilization [16,17]. Since composition of the sperm membrane appears to be important in infertility, this poses the possibility that the w-6/w-3 ratio and Coenzyme Q10 content of the spermatozoa can influence progesterone activity and its sensing by Ca +2 channels [14,[18][19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

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Can a High W-6/W-3 Fatty Acid Ratio in The Tissues Predispose Infertility?

Fedačko¹

2011

TONUTRAJ

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Abstract:Mediterranean diet appears to be protective and Western diet may be a risk factor for emergence of noncommunicable diseases (NCDS), including infertility. Inflammation is the most important manifestation and risk factor for NCDs which can be prevented by increased intake of Mediterranean foods rich in omega 3 fatty acids (w-3). The biochemical contents of sperm and seminal fluid as well as of egg coating is also imperative in the mechanism of fertilization. Progesterone is known to activate CatSper, (cation channel of sperm) the principal Ca 2+ channel of the sperm flagellum which is important in fertilization. The receptors on the external cell membrane to which progesterone binds may be under the influence of various nutrients. The present review is focused on the significance of w-6 to w-3 ratio on the motility of sperms. Majority of cytoprotective neutraceuticals including w-3 fatty acids and Coenzyme Q 10 (CoQ10) are present in the mitochondria cell membranes. Since composition of the spermatozoa may be important in infertility, this poses the possibility that w-6/w-3 ratio of the spermatozoa and seminal fluid can influence progesterone activity and its sensing by the Ca +2 channel.Recent studies demonstrated that the CatSper channel serves as a novel progesterone receptor that can mediate a fast, non-genomic effect of progesterone at the level of the sperm plasma membrane. Further studies are necessary to find out the role of w-6/w-3 ratio and CoQ10 levels on Ca +2 channels of the sperm, in the seminal fluid and ova.

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Decreased polyunsaturated and increased saturated fatty acid concentration in spermatozoa from asthenozoospermic males as compared with normozoospermic males

Cited by 99 publications

References 25 publications

Season-induced variation in lipid composition is associated with semen quality in Holstein bulls

Season-induced variation in lipid composition is associated with semen quality in Holstein bulls

The roles of omega-3 and omega-6 fatty acids in idiopathic male infertility

Can a High W-6/W-3 Fatty Acid Ratio in The Tissues Predispose Infertility?

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