Decreased platelet distribution width predicts a worse prognosis in patients undergoing surgical resection for hepatocellular carcinoma

Yue, Chen-xi; Liu, Yuxi; Yun, Zhiyuan; Li, Na; Zhao, Chang-Jiu

doi:10.3233/cbm-190474

Cited by 6 publications

(4 citation statements)

References 20 publications

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“…Nevertheless, the data dealing with these subjects were conflicting among studies. Low PDW has proved to be a strong correlation with poor prognosis in lung ( 28 ), colon ( 29 ), hepatocellular ( 30 ), endometrial ( 31 ), and esophageal cancers ( 32 ), which is consistent with our findings. In the genitourinary tumors, low PDW has shown to be related to more advanced stages in bladder cancer ( 33 ).…”

Section: Discussionsupporting

confidence: 91%

Preoperative Platelet Distribution Width Represents a Novel Prognostic Biomarker in Patients With Nonmetastatic Renal Cell Carcinoma: A Retrospective Clinical Analysis

et al. 2022

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PurposeThe study aimed to explore the prognostic value of platelet distribution width (PDW) in patients with nonmetastatic renal cell carcinoma (RCC).MethodsWe retrospective analyzed 706 patents with nonmetastatic RCC from January 2015 to December 2017. Clinicopathologic data and platelet indices were collected and analyzed by univariable and multivariable cox proportional hazard model. Progression-free survival (PFS) was analyzed using the Kaplan–Meier curve. Net reclassification improvement (NRI) and integrated discrimination improvement (IDI) were performed to evaluate the improvement of predictive accuracy.ResultsPatients were divided into low PDW (N = 241, PDW ≤11.7%), intermediate PDW (N = 232, 11.7%< PDW ≤15.6%), and high PDW (N = 233, PDW >15.6%) groups according to the tertiles. Patients with low PDW were associated with more symptoms at presentation, larger tumor size, higher AJCC tumor stage, and more sarcomatoid differentiation. Besides, patients with low PDW had significantly shorter PFS compared to intermediate PDW and high PDW groups. On the multivariable model, AJCC tumor stage, nuclear grade, and PDW (either continuous or categorical variables) were independent factors correlated with PFS. The NRI and IDI showed adding PDW to SSIGN score improves its predictive accuracy related to 2-, 3-, and 4-year PFS.ConclusionsLow PDW was related to advanced clinicopathologic features and worse prognosis in patients with nonmetastatic RCC. Thus, PDW could serve as a novel biomarker for risk stratification in these patients when used pre-or postoperatively.

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Section: Discussionsupporting

confidence: 91%

Preoperative Platelet Distribution Width Represents a Novel Prognostic Biomarker in Patients With Nonmetastatic Renal Cell Carcinoma: A Retrospective Clinical Analysis

et al. 2022

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“…17 To hepatocellular carcinoma patients, elevated PDW could give assistance to forecast the worse prognosis, while to patients undergoing surgical resection for hepatocellular carcinoma, low PDW predicts a poor prognosis. 18,19 In the current study, the result displayed that high PDW is significantly associated with in-hospital death in TAAAD patients.…”

Section: Discussionmentioning

confidence: 51%

A simple model predicting in-hospital death in patients with type A acute aortic dissection

et al. 2021

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Background: Type A acute aortic dissection (TAAAD) is a destructive cardiovascular disease, with high morbidity and mortality rates. Identifying the high-risk TAAAD patients at an early stage is urgently necessary. Methods: A retrospective study of 160 patients was carried out. The admission data were retrospectively gathered. Logistic regression analysis and receiver operator characteristic curve (AUC) was utilized. Results: Compared with the survivor group, the nonsurvivor group was older, had higher D-dimer levels, red blood cell distribution width (RDW) levels and platelet distribution width (PDW) levels, and lower fibrinogen levels, platelet levels and plateletcrit levels. Multivariate analysis displayed that four independent factors, age (hazard ratio (HR): 7.877, 95% confidence interval (CI) 2.740–22.641, p < 0.001), D-dimer (HR: 3.791, 95% CI 1.520–9.452, p = 0.004), RDW (HR: 3.300, 95% CI 1.109–9.825, p = 0.032), PDW (HR: 3.755, 95% CI 1.436–9.815, p = 0.007) were incorporated into the model. The predict accuracy of the model (AUC 0.861, 95% CI 0.798–0.911, p < 0.001) was best. Conclusions: Age, D-dimer, RDW and PDW are independent markers of in-hospital death in TAAAD patients and the newly established model has better performance in predicting high-risk patients. This model can be used as a quick screening tool to assess the prognosis of patients in individualizing.

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“…At present, PDW has been proven to be critical in the prediction of liver metastasis in colorectal cancer and distant metastasis in gastric cancer [ 9 ]. PDW levels were also found to predict poor survival in HCC in our previous study [ 10 ]. However, no study has investigated the association between PDW and PM following hepatectomy for HCC.…”

Section: Introductionmentioning

confidence: 73%

“…In addition, numerous clinical studies revealed a strong link between PDW and the prognosis of various cancers such as breast cancer, colon cancer, ovarian cancer, and non-small cell lung cancer [ 20 – 23 ]. Meanwhile, several reports have also confirmed that PDW is an independent predictor of poor clinical outcome in HCC [ 10 , 24 , 25 ]. Interleukin-6 (IL-6), granulocyte colony-stimulating factor (G-CSF), and macrophage colony-stimulating factor (M-CSF) have all been found to influence megakaryocytic maturation, platelet production, and platelet volume [ 26 ].…”

Section: Discussionmentioning

confidence: 93%

Preoperative PDW levels predict pulmonary metastasis in patients with hepatocellular carcinoma

et al. 2022

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Background In hepatocellular carcinoma (HCC), pulmonary metastasis (PM) after hepatectomy is associated with poor clinical outcomes. The crucial phases of tumour cell proliferation, angiogenesis, and metastasis all entail platelet activation. In HCC, platelet distribution width (PDW) suggests platelet size changes and predicts a worse prognosis. The aim of this study was to assess the association between PDW and PMs in HCC patients receiving hepatectomy. Material/methods From January 2013 to December 2015, a cohort of patients who underwent hepatectomy for HCC at the Harbin Medical University Cancer Hospital in China were retrospectively evaluated. The relationship between PDW levels and clinical and demographic parameters was examined. To investigate the relationships between predicted factors and PM, a competing risk model was used. From January 2016 to December 2018, a validation cohort of 109 patients from the First Affiliated Hospital of Harbin Medical University was studied independently. Results In the primary cohort, 19 out of 214 patients had postoperative PMs. In HCC patients with PM, PDW levels were lower than in those without PM. There was a significant difference in the cumulative incidence of 2-year PM between the high-PDW and low-PDW groups after controlling for competing risk events (death prior to the development of PM) (p < 0.001). In addition, PDW was also found to be an independent predictor for PM in a multivariable competing risk analysis. The results were externally validated in another cohort. Conclusions In HCC, preoperative PDW is significantly associated with PM. PDW could be a biomarker for post-operative PM in HCC patients.

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Decreased platelet distribution width predicts a worse prognosis in patients undergoing surgical resection for hepatocellular carcinoma

Cited by 6 publications

References 20 publications

Preoperative Platelet Distribution Width Represents a Novel Prognostic Biomarker in Patients With Nonmetastatic Renal Cell Carcinoma: A Retrospective Clinical Analysis

Preoperative Platelet Distribution Width Represents a Novel Prognostic Biomarker in Patients With Nonmetastatic Renal Cell Carcinoma: A Retrospective Clinical Analysis

A simple model predicting in-hospital death in patients with type A acute aortic dissection

Preoperative PDW levels predict pulmonary metastasis in patients with hepatocellular carcinoma

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