Decreased plasma decorin levels following acute ischemic stroke: Correlation with MMP-2 and differential expression in TOAST subtypes

Xu, Yuanzhi; Zhao, Kaijun; Yang, Zhigang; Zhang, Yuhui; Zhang, Yong‐Wei; Hong, Bo; Liu, Jianmin

doi:10.3892/mmr.2012.1108

Cited by 7 publications

(3 citation statements)

References 39 publications

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“…The mechanism underlying the reduction in circulating MMP‐2 is unclear. Most inflammatory disease states do not demonstrate this pattern, but similar alterations have been described in ischemic stroke . During ischemic injury, cerebrovascular endothelial cells are the major source of circulating MMP‐2 .…”

Section: Discussionmentioning

confidence: 75%

Circulating matrix metalloproteinases in children with diabetic ketoacidosis

et al. 2016

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Background and objective Matrix metalloproteinases (MMPs) mediate blood–brain barrier dysfunction in inflammatory disease states. Our objective was to compare circulating MMPs in children with diabetic ketoacidosis (DKA) to children with type 1 diabetes mellitus without DKA. Research design and methods This was a prospective study performed at five tertiary-care pediatric hospitals. We measured plasma MMP-2, MMP-3, and MMP-9 early during DKA (time 1; within 2 h of beginning intravenous fluids) and during therapy (time 2; median 8 h; range: 4–16 h). The primary outcome was MMP levels in 34 children with DKA vs. 23 children with type 1 diabetes without DKA. Secondary outcomes included correlations between MMPs and measures of DKA severity. Results In children with DKA compared with diabetes controls, circulating MMP-2 levels were lower (mean 77 vs. 244 ng/mL, p < 0.001), MMP-3 levels were similar (mean 5 vs. 4 ng/mL, p = 0.57), and MMP-9 levels were higher (mean 67 vs. 25 ng/mL, p = 0.002) early in DKA treatment. MMP-2 levels were correlated with pH at time 1 (r = 0.45, p = 0.018) and time 2 (r = 0.47, p = 0.015) and with initial serum bicarbonate at time 2 (r = 0.5, p = 0.008). MMP-9 levels correlated with hemoglobin A1c in DKA and diabetes controls, but remained significantly elevated in DKA after controlling for hemoglobin A1c (β = −31.3, p = 0.04). Conclusions Circulating MMP-2 levels are lower and MMP-9 levels are higher in children during DKA compared with levels in children with diabetes without DKA. Alterations in MMP expression could mediate BBB dysfunction occurring during DKA.

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Section: Discussionmentioning

confidence: 75%

Circulating matrix metalloproteinases in children with diabetic ketoacidosis

et al. 2016

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“…CAR-DCN treatment increases DCN and collagen levels in the vessel wall [ 46 ]. DCN expression correlated with IS severity, and DCN expression was significantly lower in patients with IS [ 47 ]. (3) PDGFRB plays an important role in vascular development by promoting the proliferation of pericytes and smooth muscle cells to endothelial cells, neointima formation at sites of vascular injury, and contributes to the rearrangement of the actin cytoskeleton.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol: a potential medication for the prevention and treatment of varicella zoster virus-induced ischemic stroke

Wang,

Chen,

Song

et al. 2023

Eur J Med Res

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Background Infection rate of varicella zoster virus (VZV) is 95% in humans, and VZV infection is strongly associated with ischemic stroke (IS). However, the underlying molecular mechanisms of VZV-induced IS are still unclear, and there are no effective agents to treat and prevent VZV-induced IS. Objective By integrating bioinformatics, this study explored the interactions between VZV and IS and potential medication to treat and prevent VZV-induced IS. Methods In this study, the VZV and IS datasets from the GEO database were used to specify the common genes. Then, bioinformatics analysis including Gene Ontology, Kyoto Encyclopedia Genes Genomes and Protein–Protein Interaction network analysis was performed. Further, the hub genes, transcription factor (TF) gene interactions, TF-miRNA co-regulatory network and potential drug were obtained. Finally, validation was performed using molecular docking and molecular dynamics simulations. Results The potential molecular mechanisms of VZV-induced IS were studied using multiple bioinformatics tools. Ten hub genes were COL1A2, DCN, PDGFRB, ACTA2, etc. TF genes and miRNAs included JUN, FOS, CREB, BRCA1, PPARG, STAT3, miR-29, etc. A series of mechanism may be involved, such as inflammation, oxidative stress, blood–brain barrier disruption, foam cell generation and among others. Finally, we proposed resveratrol as a potential therapeutic medicine for the prevention and treatment of VZV-induced IS. Molecular docking and molecular dynamics results showed that resveratrol and hub genes exhibited strong binding score. Conclusions Resveratrol could be an alternative for the prevention and treatment of VZV-IS. More in vivo and in vitro studies are needed in the future to fully explore the molecular mechanisms between VZV and IS and for medication development.

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“…Circulating plasma decorin levels in humans have been found to be elevated in type 2 diabetes compared to controls (Bolton et al, 2008). There is evidence to suggest an important role of decorin in attenuating progression of atherosclerosis (Singla et al, 2011), and a reduction in plasma levels of decorin has been found in patients following acute ischemic stroke (Xu et al, 2012). A proteolytic isoform of decorin devoid of the N-terminal glycosaminoglycan chain expressed on adipocyte stromal cell surfaces appears to serve as a receptor for resistin in mice (Daquinag et al, 2011).…”

Section: Introductionmentioning

confidence: 97%