Decreased Plasma Brain‐Derived Neurotrophic Factor Levels in Patients With Alcohol Dependence

Joe, Keun Ho; Kim, Yong Ku; Kim, Tae Suk; Roh, Sung Won; Choi, Sam; Kim, Young Bo; Lee, Hee Jin; Kim, Daijin

doi:10.1111/j.1530-0277.2007.00507.x

Cited by 115 publications

(91 citation statements)

References 26 publications

(31 reference statements)

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“…Several studies have reported alterations of BDNF serum levels in patients suffering from substance-related addictions such as alcohol and opiate dependence [26,27,32]. In the present study, we found increased serum concentrations of BDNF in a sample of male patients with PG in comparison to individually matched healthy male control subjects.…”

Section: Discussionsupporting

confidence: 68%

“…Furthermore, it has been shown that reduced BDNF expression was associated with increased alcohol-related behaviour in rodents, whereas increased BDNF expression attenuated these behaviours [25]. In alcohol-dependent patients who had abstained from alcohol for at least 30 days, plasma levels of BDNF were found to be decreased in comparison to healthy controls [26]. In contrast, Lee et al [27] reported increased plasma levels of BDNF in alcohol-dependent patients within 24 h of abstinence.…”

Section: Introductionmentioning

confidence: 99%

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Altered Serum Levels of Brain-Derived Neurotrophic Factor in Patients with Pathological Gambling

Geisel

Banas²,

Hellweg³

et al. 2012

Eur Addict Res

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Background: Brain-derived neurotrophic factor (BDNF) plays important roles in neurotransmitter release and synaptic plasticity and has been hypothesized to be involved in the development and maintenance of addictive disorders. The objective of this study was to investigate alterations of BDNF expression in a non-substance-related addiction, i.e. pathological gambling (PG). Methods: Serum levels of BDNF were assessed in male patients with PG (n = 14) and healthy control subjects (n = 13) carefully matched for sex, age, body mass index, smoking status and urbanicity. Symptoms and severity of PG were measured by the adapted form of the Yale-Brown Obsessive-Compulsive Scale. Results: BDNF serum levels were significantly increased in patients with PG in comparison to healthy control subjects (p = 0.016). There were no significant correlations between BDNF serum levels and severity of PG or clinical and demographic variables. Conclusions: Our results show alterations of BDNF serum levels in patients suffering from a behavioural addiction and suggest that non-substance-related addictions like PG might be associated with neuroendocrinological changes similar to the changes observed in substance-related addictions.

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Section: Discussionsupporting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Altered Serum Levels of Brain-Derived Neurotrophic Factor in Patients with Pathological Gambling

Geisel

Banas²,

Hellweg³

et al. 2012

Eur Addict Res

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show abstract

“…Lee et al [18] found significantly increased BDNF blood levels in male alcohol-dependent patients compared to the healthy controls. In contrast, Joe et al [12 ]demonstrated that BDNF blood levels are significantly reduced in alcohol-dependent patients that had abstained for more than 30 days. Zanardini et al [11] could show a significant reduction in BDNF serum in the patient group compared to healthy subjects, but not in plasma.…”

Section: Introductionmentioning

confidence: 99%

“…Serum BDNF might therefore reflect the content of whole blood. It is also important to consider the phases of alcoholism dependence of the patients in which BDNF was determined [12]. …”

Section: Introductionmentioning

confidence: 99%

Serum Brain-Derived Neurotrophic Factor and Nerve Growth Factor Concentrations Change after Alcohol Withdrawal: Preliminary Data of a Case-Control Comparison

et al. 2012

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Background: Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are involved in neuroadaptation and foster survival of central and peripheral neurons. In this study, we addressed the question whether BDNF and NGF serum concentrations change during subacute alcohol withdrawal in patients with alcohol dependence compared to healthy controls. Methods: Fifteen patients (age 48.6 ± 7 years) and 15 healthy age-matched controls (age 48.8 ± 7 years) participated consecutively in a 2-week withdrawal study. Results: Mean BDNF levels (7.8 ng/ml, IQR = 4.4–10.7 vs. 16.5 ng/ml, IQR = 13.9–25.6; Z = –3.8, p < 0.0001) and NGF levels (5.8 pg/ml, IQR = 3.8–13.0 vs. 18.4 pg/ml, IQR = 10.9–25.1; Z = –2.5, p = 0.012) were significantly decreased in alcohol-dependent subjects when compared to healthy matched controls. NGF concentrations decreased significantly from day 3 to day 14 (Z = –2.36; p = 0.019). Mean BDNF concentrations showed a tendency to increase after withdrawal from day 3 to day 14 (Z = 1.7; p = 0.078). Conclusion: Decreased NGF and BDNF concentrations in patients suffering from alcohol dependence, which stabilize after physical withdrawal, are in line with withdrawal symptoms and neurological risk factors. In turn, increase of BDNF after acute withdrawal might be connected to neurobiological and behavioral stabilization.

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“…A ativação locomotora é vista como uma evidência da participação do sistema dopaminérgico mesocorticolímbico (WISE e BOZARTH 1987 (JOE et al, 2007). …”

Section: Dependência Na Adolescênciaunclassified

Alterações na ativação do CREB e nos níveis de BDNF induzidas pelo etanol em camundongos adolescentes e adultos.

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Decreased Plasma Brain‐Derived Neurotrophic Factor Levels in Patients With Alcohol Dependence

Abstract: Changes in the levels of BDNF might play a role in the pathophysiology and inheritance of alcohol dependence.

Cited by 115 publications

References 26 publications

Altered Serum Levels of Brain-Derived Neurotrophic Factor in Patients with Pathological Gambling

Altered Serum Levels of Brain-Derived Neurotrophic Factor in Patients with Pathological Gambling

Serum Brain-Derived Neurotrophic Factor and Nerve Growth Factor Concentrations Change after Alcohol Withdrawal: Preliminary Data of a Case-Control Comparison

Alterações na ativação do CREB e nos níveis de BDNF induzidas pelo etanol em camundongos adolescentes e adultos.

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