Decreased plasma adiponectin concentrations in women with gestational diabetes mellitus

Worda, Christof; Leipold, Heinz; Gruber, Christian J.; Kautzky‐Willer, Alexandra; Knöfler, Martin; Bancher‐Todesca, Dagmar

doi:10.1016/j.ajog.2004.04.038

Cited by 126 publications

(97 citation statements)

References 26 publications

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“…Previous studies have shown that hypoadiponectinaemia is a hallmark of situations where insulin resistance occurs, including obesity, type 2 diabetes and gestational diabetes [12,[24][25][26]. Our longitudinal analysis in women from the pregravid state to the third trimester indicates that pregnancy in humans is a physiological situation in which circulating adiponectin is decreased, as is found in mice [11,27].…”

Section: Pregnancy Is a Situation Of Hypoadiponectinaemiasupporting

confidence: 61%

Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism

et al. 2006

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Aims/hypothesis: Adiponectin is upregulated during adipogenesis and downregulated in insulin-resistant states. The mechanism(s) governing the re-arrangements from adipogenesis to facilitated lipolysis during pregnancy are unknown. Our purpose was to analyse the role of adiponectin relative to the metabolic changes in human pregnancy. Subjects, materials and methods: Lean women (BMI <25 kg/m²) were evaluated longitudinally before conception, and in early (12-14 weeks) and late (34-36 weeks) pregnancy. Insulin sensitivity was measured using the glucose clamp technique. Venous blood and subcutaneous adipose tissue biopsies were obtained at each time point. Results: Adiponectin concentrations were lower in the third trimester than in the pregravid condition (9.9±1.4 vs 13.5±1.8 μg/ml). The hypoadiponectinaemia was reflected by a 2.5-fold decrease in white adipose tissue adiponectin mRNA. These changes were associated with a 25% increase in fat mass (23.7±2.9 vs 18.9±2.9 kg). Insulin infusion decreased high molecular weight adiponectin complexes in pregravid women (9.9±0.6 vs 6.2±0.06) and the suppressive effect of insulin was lost during pregnancy. The pregnancy-mediated changes in adiponectin were strongly correlated with basal insulin levels and insulin sensitivity (p<0.0001). The relationship between adiponectin and insulin sensitivity was related to the decreased insulin regulation of glucose utilisation (r=0.55, p<0.001) but not of endogenous hepatic glucose production. Conclusions/interpretation: These data demonstrate that pregnancy is associated with adiponectin changes in lean women. Hypoadiponectinaemia is reflected by a lower amount of high molecular weight adiponectin and by the ratio of high to low molecular weight multimers. The adiponectin changes relate to decreased insulin sensitivity of glucose disposal rather than alterations of lipid metabolism.

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Section: Pregnancy Is a Situation Of Hypoadiponectinaemiasupporting

confidence: 61%

Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism

et al. 2006

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“…9 In contrast to our observation of decreasing levels of adiponectin from mid-gestation onwards, a positive correlation between gestational age and adiponectin levels reached statistical significance in a study using single measurements from pregnant normal and GDM women over a range of gestational ages. 3 In that study, no association was detected between BMI and adiponectin. 3 In contrast, two other studies noted an inverse relationship between adiponectin levels and BMI, 2,4 in accordance with our results.…”

Section: Adiponectin During Pregnancymentioning

confidence: 75%

“…[2][3][4] Cseh et al 2 found lower levels of adiponectin in 30 pregnant women with gestational diabetes mellitus (GDM) compared with 40 nondiabetic controls. Similar findings were observed by Worda et al 3 in 20 GDM women compared with 21 non-diabetic controls. In both studies, no differences in mean gestational age was observed between groups, although the range of gestational ages in each of the groups was high.…”

Section: Introductionmentioning

confidence: 99%

Short communication: A longitudinal study of serum adiponectin during normal pregnancy

Fuglsang

Skjærbæk

Frystyk

et al. 2005

BJOG

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Adiponectin is secreted from adipose tissue. Serum adiponectin levels are inversely correlated with body mass index (BMI) and also insulin resistance, independent of the BMI. A role for adiponectin in the development of insulin resistance has been implied in pregnancy. However, no studies have been performed to describe the individual longitudinal course of adiponectin in normal pregnancies. Therefore, we measured serum adiponectin during and after normal pregnancy in 11 healthy women. Serum levels peaked in midpregnancy and the lowest levels were seen in late pregnancy. An inverse association with maternal BMI was observed.Please cite this paper as: Fuglsang J, Skjaerbaek C, Frystyk J, Flyvbjerg A, Ovesen P. A longitudinal study of serum adiponectin during normal pregnancy.

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“…16 Consistent with the non-pregnant state, adiponectin levels are reduced in patients with GDM when compared with normal pregnant women. [6][7][8][9] Moreover, lower first trimester adiponectin levels are predictive for the development of GDM later in pregnancy. 17 Finally, adiponectin levels during pregnancy are found to be negatively correlated with insulin resistance.…”

Section: Commentmentioning

confidence: 99%

“…Despite the important role of this hormone in the regulation of insulin sensitivity in physiological and pathological conditions, little is known about the role of this hormone during pregnancy. Although there are several studies concerning the association between adiponectin and gestational diabetes [6][7][8][9][10] or pre-eclampsia, [10][11][12] only few studies focused their attention on studying normal pregnant subjects. Moreover, there is only one study regarding adiponectin levels during pregnancy and as far as we are aware there are no comparative studies of adiponectin concentrations between the different trimesters and the immediate postpartum period.…”

Section: Introductionmentioning

confidence: 99%

Maternal serum adiponectin levels during human pregnancy

et al. 2007

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Objective: Pregnancy is a unique situation characterized by insulin resistance. The role of adiponectin, an insulin-sensitizing hormone, has not been completely clarified during pregnancy. The aim of this cross-sectional study was to evaluate adiponectin levels during pregnancy and postpartum. Study design:Adiponectin and leptin levels were tested in 80 pregnant women, 20 in each trimester (mean gestational age 10.5±1.9; 19.3±4.9; 39.3±0.8 weeks,) as well as 4 days postpartum.Results: Adiponectin levels during first (13.3±3.6 mg/ml), second (12.6±4.4 mg/ml) and third trimester (11.2±3.7 mg/ml) did not differ and were significantly higher than postpartum levels (8.8±2.1 mg/ml; P<0.0001, P<0.004 and P<0.02, respectively). Conclusion:Despite increased insulin resistance during pregnancy, no significant alterations in adiponectin levels were observed. This may imply that the regulation of adiponectin during gestation is altered. The elevated gestational adiponectin levels are consistent with increased 'adiponectin resistance' during pregnancy.

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Decreased plasma adiponectin concentrations in women with gestational diabetes mellitus

Cited by 126 publications

References 26 publications

Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism

Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism

Short communication: A longitudinal study of serum adiponectin during normal pregnancy

Maternal serum adiponectin levels during human pregnancy

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