Decreased P300 current source density in drug-naive first episode schizophrenics revealed by high density recording

Wang, Jijun; Tang, Yue; Li, Chunbo; Mecklinger, Axel; Xiao, Zeping; Zhang, Mingdao; Hirayasu, Yoshio; Hokama, Hiroto; Li, Hui

doi:10.1016/j.ijpsycho.2009.12.005

Cited by 23 publications

(16 citation statements)

References 56 publications

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“…Previous studies suggested that aberrations of P300 amplitude in schizophrenia patients were indicators of these dysfunctions [38], which might be further related to structural and functional changes in the schizophrenia patient's temporal lobe and parietal lobe [39]. Although most of the previous studies reported a reduced P300 amplitude at Pz/Cz electrode in FES patients [16]–[20], [25]–[29], [21]–[36], some studies reported negative results [30], [40]. A variety of factors, such as disease severity and sample size, might explain this apparently inconsistent result [12].…”

Section: Discussionmentioning

confidence: 96%

P300 Aberration in First-Episode Schizophrenia Patients: A Meta-Analysis

et al. 2014

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BackgroundDecreased P300 amplitude is one of the most consistent findings in patients with schizophrenia. However, whether prolonged P300 latency occurs in patients with schizophrenia, especially first-episode schizophrenia (FES) patients, remains controversial.MethodsA meta-analyses of P300 aberration in FES patients and healthy control(HC) group was conducted. The meta-regression analysis was performed using a random effects model. The pooled standardized effect size (PSES) was calculated as the division of the difference between the means of the two groups by the common standard deviation.ResultsA total of 569 FES patients and 747 HCs were included in this meta- analysis. P300 amplitude was significantly reduced (PSES = −0.83, 95% CI: −1.02–0.65, P = 0.00001) and P300 latency was delayed significantly in FES patients (PSES = −0.48, 95% CI: 0.14–0.81, P = 0.005). The meta-regression analysis showed that task difficulty was a source of heterogeneity.ConclusionsThe meta-analysis confirms that disrupted information processing is found in FES patients, which is manifested by smaller P300 amplitude and delayed P300 latency.

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Section: Discussionmentioning

confidence: 96%

P300 Aberration in First-Episode Schizophrenia Patients: A Meta-Analysis

et al. 2014

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“…It is noteworthy that the previous LORETA findings are influenced by one important technical shortcoming: although ERP analyses show a considerable inter-subject variability of P300 latency (Campanella et al, 1999), LORETA source imaging studies commonly used a large fixed post-stimulus window of interest (WOI), like [250 500] ms (Higuchi et al, 2008;Kawasaki et al, 2007;Sumiyoshi et al, 2006), [280 450] ms (Wang et al, 2003(Wang et al, , 2010, [240 420] ms (Pae et al, 2003), [227 383] ms , or [400 700] ms (Wronka et al, 2012).…”

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confidence: 99%

Auditory P3a and P3b neural generators in schizophrenia: An adaptive sLORETA P300 localization approach

Bachiller

Romero

Molina

et al. 2015

Schizophrenia Research

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The present study investigates the neural substrates underlying cognitive processing in schizophrenia (Sz) patients. To this end, an auditory 3-stimulus oddball paradigm was used to identify P3a and P3b components, elicited by rare-distractor and rare-target tones, respectively. Event-related potentials (ERP) were recorded from 31 Sz patients and 38 healthy controls. The P3a and P3b brain-source generators were identified by time-averaging of low-resolution brain electromagnetic tomography (LORETA) current density images. In contrast with the commonly used fixed window of interest (WOI), we proposed to apply an adaptive WOI, which takes into account subjects' P300 latency variability. Our results showed different P3a and P3b source activation patterns in both groups. P3b sources included frontal, parietal and limbic lobes, whereas P3a response generators were localized over bilateral frontal and superior temporal regions. These areas have been related to the discrimination of auditory stimulus and to the inhibition (P3a) or the initiation (P3b) of motor response in a cognitive task. In addition, differences in source localization between Sz and control groups were observed. Sz patients showed lower P3b source activity in bilateral frontal structures and the cingulate. P3a generators were less widespread for Sz patients than for controls in right superior, medial and middle frontal gyrus. Our findings suggest that target and distractor processing involves distinct attentional subsystems, both being altered in Sz. Hence, the study of neuroelectric brain information can provide further insights to understand cognitive processes and underlying mechanisms in Sz.

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“…Abnormalities in P3 may reflect a failure to allocate attention resources to a stimulus and/or deficits in information processing and cognitive updating. P3 impairments are also consistently observed in neuroleptic‐naive FEP patients (Brown, Gonsalvez, Harris, Williams, & Gordon, ; de Wilde et al, ; Demiralp et al, ; Hermens et al, ; Hirayasu et al, ; Kaur et al, ; McCarley et al, ; Ozgurdal et al, ; Renoult et al, ; van der Stelt, Lieberman, & Belger, ; Wang et al, ; Xiong et al, ) and in individuals at clinical high risk for psychosis (Bramon et al, ; Frommann et al, ; Nieman et al, ; Ozgurdal et al, ; van der Stelt et al, ). Interestingly, it was shown that P300 peak amplitude significantly predicted later improvement in negative and general symptoms in high risk individuals who did not transition to psychosis within 2 years of EEG recording (Kim, Lee, Lee, Kim, & Kwon, ).…”

Section: Event‐related Potentialsmentioning

confidence: 86%

Staging model in psychiatry: Review of the evolution of electroencephalography abnormalities in major psychiatric disorders

Lavoie

Polari

Goldstone

et al. 2019

Early Intervention Psych

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Aim Clinical staging in psychiatry aims to classify patients according to the severity of their symptoms, from stage 0 (increased risk, asymptomatic) to stage 4 (severe illness), enabling adapted treatment at each stage of the illness. The staging model would gain specificity if one or more quantifiable biological markers could be identified. Several biomarkers reflecting possible causal mechanisms and/or consequences of the pathophysiology are candidates for integration into the clinical staging model of psychiatric illnesses. Methods This review covers the evolution (from stage 0 to stage 4) of the most important brain functioning impairments as measured with electroencephalography (EEG), in psychosis spectrum and in severe mood disorders. Results The present review of the literature demonstrates that it is currently not possible to draw any conclusion with regard to the state or trait character of any of the EEG impairments in both major depressive disorder and bipolar disorder. As for schizophrenia, the most promising markers of the stage of the illness are the pitch mismatch negativity as well as the p300 event‐related potentials, as these components seem to deteriorate with increasing severity of the illness. Conclusions Given the complexity of major psychiatric disorders, and that not a single impairment can be observed in all patients, future research should most likely consider combinations of markers in the quest for a better identification of the stages of the psychiatric illnesses.

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Decreased P300 current source density in drug-naive first episode schizophrenics revealed by high density recording

Cited by 23 publications

References 56 publications

P300 Aberration in First-Episode Schizophrenia Patients: A Meta-Analysis

P300 Aberration in First-Episode Schizophrenia Patients: A Meta-Analysis

Auditory P3a and P3b neural generators in schizophrenia: An adaptive sLORETA P300 localization approach

Staging model in psychiatry: Review of the evolution of electroencephalography abnormalities in major psychiatric disorders

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