Decreased ovarian function is associated with obesity in very long-term female survivors of childhood cancer

Dorp, Wendy van; Blijdorp, Karin; Laven, Joop S.E.; Pieters, Rob; Visser, Jenny A.; Lely, A.J. van der; Neggers, Sebastian J C M M; Heuvel‐Eibrink, Marry M. van den

doi:10.1530/eje-13-0114

Cited by 29 publications

(15 citation statements)

References 41 publications

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“…In this study, AMH was not related to any metabolic parameters [31]. When researching the degree of insulin resistance or level of fasting insulin alone in relation to AMH, a significant correlation was found by two studies [32,33], whereas another study was not able to confirm this correlation [34].…”

Section: Relationship Of Amh With Metabolic Parameterscontrasting

confidence: 65%

Anti-Müllerian Hormone as a marker of ovarian reserve in relation to cardio-metabolic health: A narrative review

et al. 2015

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Section: Relationship Of Amh With Metabolic Parameterscontrasting

confidence: 65%

Anti-Müllerian Hormone as a marker of ovarian reserve in relation to cardio-metabolic health: A narrative review

et al. 2015

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“…On one hand, higher BMI has not been shown to be associated with earlier ovarian aging, as demonstrated by earlier menopause [20]. On the other hand, lower AMH, an indirect measure of poor ovarian reserve, is seen in virtually all reports on the subject [24][25][26][27]. In our study there was a trend towards lower AMH and growing follicle numbers in obese animals exposed to HFD for 32 wk, yet it did not reach statistical significance.…”

Section: Skaznik-wikiel Et Alcontrasting

confidence: 80%

High-Fat Diet Causes Subfertility and Compromised Ovarian Function Independent of Obesity in Mice

Skaznik-Wikiel

Swindle

Allshouse

et al. 2016

Obstetrical &Amp; Gynecological Survey

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Excess calorie consumption, particularly of a diet high in fat, is a risk factor for both obesity and reproductive disorders. Animal model studies indicate that elevated dietary fat can influence some reproductive functions independent of obesity. In the current study we sought to determine whether a high-fat diet (HFD) impacts ovarian function, long-term fertility, and local and systemic markers of inflammation independent of obesity. Five-week-old mice were fed either low-fat diet (control group-LF-Ln) or HFD for 10 wk and were divided based on body weight into high-fat obese (HF-Ob: .25 g) and high-fat lean (HFLn: ,22 g). Ovaries were collected to assess ovarian follicles and to determine the degree of local inflammation. Serum proinflammatory cytokines were also measured. A group of animals was followed for breeding trials for 5 mo while being exposed to LFD or HFD. We found that both 10-wk and 32-wk exposure to HFD resulted in depleted primordial follicles regardless of obesity phenotype. Macrophage counts revealed increased tissue inflammation in the ovary independent of obesity. In addition, serum proinflammatory cytokines were increased in HF-Ln and HF-Ob in comparison to LF-Ln mice. Moreover, HFD had a sustained effect on litter production rate and number of pups per litter regardless of obese phenotype. This study describes for the first time that exposure to HFD causes significant reduction in primordial follicles, compromised fertility, produced higher proinflammatory cytokine levels, and increased ovarian macrophage infiltration, independent of obesity. The negative effects of HFD on primordial follicles may be mediated by increased tissue inflammation.fertility, high-fat diet, inflammation, ovary

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“…Treating physicians should implement discussions early on so that families can determine the best options for fertility preservation. It is important to remember that obesity and gonadal function are intrinsically linked and perturbations of either can adversely affect the other (37, 38). The risk of developing metabolic syndrome is also high in Childhood Cancer Survivors (CCS), particularly in patients who have received radiation therapy.…”

Section: Resultsmentioning

confidence: 99%

Bridging the gap: metabolic and endocrine care of patients during transition

Hokken-Koelega

Lely²,

Hauffa

et al. 2016

Endocrine Connections

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ObjectiveSeamless transition of endocrine patients from the paediatric to adult setting is still suboptimal, especially in patients with complex disorders, i.e., small for gestational age, Turner or Prader–Willi syndromes; Childhood Cancer Survivors, and those with childhood-onset growth hormone deficiency.MethodsAn expert panel meeting comprised of European paediatric and adult endocrinologists was convened to explore the current gaps in managing the healthcare of patients with endocrine diseases during transition from paediatric to adult care settings.ResultsWhile a consensus was reached that a team approach is best, discussions revealed that a ‘one size fits all’ model for transition is largely unsuccessful in these patients. They need more tailored care during adolescence to prevent complications like failure to achieve target adult height, reduced bone mineral density, morbid obesity, metabolic perturbations (obesity and body composition), inappropriate/inadequate puberty, compromised fertility, diminished quality of life and failure to adapt to the demands of adult life. Sometimes it is difficult for young people to detach emotionally from their paediatric endocrinologist and/or the abrupt change from an environment of parental responsibility to one of autonomy. Discussions about impending transition and healthcare autonomy should begin in early adolescence and continue throughout young adulthood to ensure seamless continuum of care and optimal treatment outcomes.ConclusionsEven amongst a group of healthcare professionals with a great interest in improving transition services for patients with endocrine diseases, there is still much work to be done to improve the quality of healthcare for transition patients.

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Decreased ovarian function is associated with obesity in very long-term female survivors of childhood cancer

Cited by 29 publications

References 41 publications

Anti-Müllerian Hormone as a marker of ovarian reserve in relation to cardio-metabolic health: A narrative review

Anti-Müllerian Hormone as a marker of ovarian reserve in relation to cardio-metabolic health: A narrative review

High-Fat Diet Causes Subfertility and Compromised Ovarian Function Independent of Obesity in Mice

Bridging the gap: metabolic and endocrine care of patients during transition

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