Decreased numbers of endothelial progenitor cells in patients in the early stages of systemic sclerosis

Andrigueti, Fernando V; Arismendi, Maria Izabel; Ebbing, Pâmela Carolina Cruz; Kayser, Cristiane

doi:10.1016/j.mvr.2015.01.004

Cited by 20 publications

(20 citation statements)

References 34 publications

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“…28 CD34 þ cells are also decreased in rheumatoid arthritis, 29 systemic lupus erythematosus, 30 and systemic sclerosis, 31 all diseases with nailfold capillary abnormalities that are comparable to POAG. 32 Most notably, in systemic sclerosis, concomitant nailfold microvascular abnormalities (dilated capillaries and avascular zones) and reduced CD34 þ cells have been reported.…”

Section: Discussionmentioning

confidence: 98%

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Nailfold Capillary Abnormalities in Primary Open-Angle Glaucoma: A Multisite Study

Pasquale

Hanyuda

Ren

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. There is considerable evidence for systemic vascular dysfunction in primary openangle glaucoma (POAG). We performed nailfold capillary video microscopy to observe directly the nature of nonocular microvasculature abnormalities in POAG. METHODS.We enrolled 199 POAG patients and 124 control subjects from four sites. We used JH-1004 capillaroscopes to perform nailfold capillary video microscopy on the fourth and fifth digits of each subject's nondominant hand. Videos were evaluated for hemorrhages, dilated capillary loops > 50 lm, and avascular zones > 100 lm by graders masked to case status. Multivariable odds ratios (ORs) and 95% confidence intervals (CIs) for POAG were obtained by means of logistic regression analyses that were applied to data from all cases and controls. Corresponding estimates of moderate or severe POAG versus mild POAG (based on the Hodapp-Anderson-Parrish scale) were obtained among cases only. RESULTS.After controlling for demographic factors, family history of glaucoma, systemic diseases, and use of anticoagulation and antiplatelet therapy, for each 100 nailfold capillaries assessed, all types of microvascular abnormalities were significantly associated with POAG. Specifically, the presence of any dilated capillaries (OR ¼ 2.9; 95% CI, 1.6-5.6), avascular zones (OR ¼ 4.4; 95% CI, 1.7-11.3) and hemorrhages (OR ¼ 12.2; 95% CI, 5.9-25.1) were associated with POAG. Among cases, the frequency of microvascular abnormalities was not associated with glaucoma severity (P ‡ 0.43).CONCLUSIONS. These data provided support for nonocular capillary bed abnormalities in POAG. Comparable vascular abnormalities in the optic nerve may render it susceptible to glaucomatous damage.

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Section: Discussionmentioning

confidence: 98%

“…32 Most notably, in systemic sclerosis, concomitant nailfold microvascular abnormalities (dilated capillaries and avascular zones) and reduced CD34 þ cells have been reported. 31,33 We hypothesize that a reduced number of these cells could lead to dilated capillaries and capillary dropout in vascular beds relevant to glaucoma. Figure 4.…”

Section: Discussionmentioning

confidence: 99%

Nailfold Capillary Abnormalities in Primary Open-Angle Glaucoma: A Multisite Study

Pasquale

Hanyuda

Ren

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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“…Although the mechanisms underlying endothelial cell damage and defective repair remain incompletely understood, a large body of evidence suggests that a profound impairment of either neoangiogenesis or endothelial progenitor cell (EPC)-driven vasculogenesis is a key feature in SSc [ 6 – 10 ]. In fact, the dysregulation of multiple cellular and molecular pathways, that are required for post-ischemic endothelial cell and EPC compensatory responses, prevents peripheral vascular recovery [ 2 , 11 – 16 ].…”

Section: Introductionmentioning

confidence: 99%

Angiogenic T cell expansion correlates with severity of peripheral vascular damage in systemic sclerosis

et al. 2017

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The mechanisms underlying endothelial cell injury and defective vascular repair in systemic sclerosis (SSc) remain unclear. Since the recently discovered angiogenic T cells (Tang) may have an important role in the repair of damaged endothelium, this study aimed to analyze the Tang population in relation to disease-related peripheral vascular features in SSc patients. Tang (CD3+CD31+CXCR4+) were quantified by flow cytometry in peripheral blood samples from 39 SSc patients and 18 healthy controls (HC). Circulating levels of the CXCR4 ligand stromal cell-derived factor (SDF)-1α and proangiogenic factors were assessed in paired serum samples by immunoassay. Serial skin sections from SSc patients and HC were subjected to CD3/CD31 and CD3/CXCR4 double immunofluorescence. Circulating Tang were significantly increased in SSc patients with digital ulcers (DU) compared either with SSc patients without DU or with HC. Tang levels were significantly higher in SSc patients with late nailfold videocapillaroscopy (NVC) pattern than in those with early/active NVC patterns and in HC. No difference in circulating Tang was found when comparing either SSc patients without DU or patients with early/active NVC patterns and HC. In SSc peripheral blood, Tang percentage was inversely correlated to levels of SDF-1α and CD34+CD133+VEGFR-2+ endothelial progenitor cells (EPC), and positively correlated to levels of vascular endothelial growth factor and matrix metalloproteinase-9. Tang were frequently detected in SSc dermal perivascular inflammatory infiltrates. In summary, our findings demonstrate for the first time that Tang cells are selectively expanded in the circulation of SSc patients displaying severe peripheral vascular complications like DU. In SSc, Tang may represent a potentially useful biomarker reflecting peripheral vascular damage severity. Tang expansion may be an ineffective attempt to compensate the need for increased angiogenesis and EPC function. Further studies are required to clarify the function of Tang cells and investigate the mechanisms responsible for their change in SSc.

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“…Many review and articles have been published on this topic (Kahlenberg, 2011;Yamaguchi et al, 2010;Hill, 2003;Manetti, 2010;Blaise et al, 2014;Andrigueti et al, 2015). Here, we aimed to review the role of EPCs in rheumatic autoimmune diseases (ARDs), including systemic lupus erythematosus, vasculitis and rheumatoid arthritis.…”

Section: Introductionmentioning

confidence: 99%

Endothelial progenitor cells: Are they displaying a function in autoimmune disorders?

Ferrante

Guggino

Liberto

et al. 2016

Mechanisms of Ageing and Development

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a b s t r a c tEndothelial Progenitor Cells (EPCs) are bone marrow derived cells able to differentiate in mature endothelial cells (EC) contributing to the generation of new vessels, connecting to fibronectin, and forming colonies and/or colony forming units.Since circulating EPCs can be actively considered part of endothelial damage in several cardiovascular diseases and autoimmune disorders the possibility to have a measure for endothelium damage should be considered of interest to predict the patient out-come. At the same time the EPCs proliferative and regenerative role could be considered for therapeutic applications.

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Decreased numbers of endothelial progenitor cells in patients in the early stages of systemic sclerosis

Cited by 20 publications

References 34 publications

Nailfold Capillary Abnormalities in Primary Open-Angle Glaucoma: A Multisite Study

Nailfold Capillary Abnormalities in Primary Open-Angle Glaucoma: A Multisite Study

Angiogenic T cell expansion correlates with severity of peripheral vascular damage in systemic sclerosis

Endothelial progenitor cells: Are they displaying a function in autoimmune disorders?

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