Decreased NSD2 impairs stromal cell proliferation in human endometrium via reprogramming H3K36me2
Chuan-Mei Qin,
Xiao-Wei Wei,
Jia-Yi Wu
et al.
Abstract:Recurrent implantation failure (RIF) is a formidable challenge in assisted reproductive technology because of its unclear molecular mechanism. Impaired human endometrial stromal cell (HESC) proliferation disrupts the rhythm of the menstrual cycle, resulting in devastating disorders between the embryo and the endometrium. The molecular function of histone methylation enzymes in modulating HESC proliferation remains largely uncharacterized. Herein, we found that the levels of histone methyltransferase nuclear re… Show more
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