Decreased NOS1 Expression in the Anterior Cingulate Cortex in Depression

Gao, Shangfeng; Qi, Xin-Rui; Zhao, Junxing; Balesar, Rawien; Bao, Ai-Min; Swaab, D.F.

doi:10.1093/cercor/bhs285

Cited by 57 publications

(52 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The findings are compatible with findings in rodents implicating NOS1 in behavioural, neural, and endocrine responses to stress (Zhou et al, 2011). In humans, post-mortem studies have shown altered NOS1 levels in the anterior cingulate cortex (Gao et al, 2013) and hippocampus (Oliveira et al 2008) of depressed patients compared with non-depressed individuals, and the NOS1 SNP rs6490121 has been associated with changes in prefrontal cortical function and grey matter density (Rose et al, 2012).…”

Section: Discussionsupporting

confidence: 86%

Neuronal Nitric Oxide Synthase (NOS1) Polymorphisms Interact with Financial Hardship to Affect Depression Risk

Sarginson

Deakin

Anderson

et al. 2014

Neuropsychopharmacol

View full text Add to dashboard Cite

There is increasing evidence that genetic factors have a role in differential susceptibility to depression in response to severe or chronic adversity. Studies in animals suggest that nitric oxide (NO) signalling has a key role in depression-like behavioural responses to stress. This study investigated whether genetic variation in the brain-expressed nitric oxide synthase gene NOS1 modifies the relationship between psychosocial stress and current depression score. We recruited a population sample of 1222 individuals who provided DNA and questionnaire data on symptoms and stress. Scores on the List of Life-Threatening Experiences (LTE) questionnaire for the last year and self-rated current financial hardship were used as measures of recent/ongoing psychosocial stress. Twenty SNPs were genotyped. Significant associations between eight NOS1 SNPs, comprising two regional haplotypes, and current depression score were identified that survived correction for multiple testing when current financial hardship was used as the interaction term. A smaller three-SNP haplotypes (rs10507279, rs1004356 and rs3782218) located in a regulatory region of NOS1 showed one of the strongest effects, with the A-C-T haplotype associating with higher depression scores at low adversity levels but lower depression scores at higher adversity levels (p ¼ 2.3E-05). These results suggest that NOS1 SNPs interact with exposure to economic and psychosocial stressors to alter individual's susceptibility to depression.

show abstract

Section: Discussionsupporting

confidence: 86%

Neuronal Nitric Oxide Synthase (NOS1) Polymorphisms Interact with Financial Hardship to Affect Depression Risk

Sarginson

Deakin

Anderson

et al. 2014

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…The hypothalamo-pituitary-adrenal (HPA)-axis, the monoamine systems and the autonomic nervous system are key regulating systems for stress responses and form major pathways for symptoms of depression [4,5]. Altered glutamatergic and reduced GABAergic and NO neurotransmission were observed in depression in a number of brain systems, which may significantly affect the neuronal activity involved in stress responses and mood regulation [1,2,6]. Changes in depression in the levels of these amino acids were found not only in different brain regions and cerebrospinal fluid (CSF), but also in blood and urine [7], which implies that they have the potential to serve as clinically relevant biomarkers or treatment efficacy monitors.…”

Section: Introductionmentioning

confidence: 99%

Decreased plasma neuroactive amino acids and increased nitric oxide levels in melancholic major depressive disorder

Shi

et al. 2014

BMC Psychiatry

Self Cite

View full text Add to dashboard Cite

BackgroundAmino acid neurotransmitters and nitric oxide (NO) are involved in the pathogenesis of major depressive disorder (MDD). Here we want to establish whether changes in their plasma levels may serve as biomarker for the melancholic subtype of this disorder.MethodsPlasma levels of glutamic acid (Glu), aspartic acid (Asp), glycine (Gly), gamma-aminobutyric acid (GABA), and NO were determined in 27 medicine-naïve melancholic MDD patients and 30 matched controls. Seven of the MDD patients participated also in a follow-up study after 2 months’ antidepressant treatment. The relationship between plasma and cerebral-spinal fluid (CSF) levels of these compounds was analyzed in an additional group of 10 non-depressed subjects.ResultsThe plasma levels of Asp, Gly and GABA were significantly lower whereas the NO levels were significantly higher in melancholic MDD patients, also after 2 months of fluoxetine treatment. In the additional 10 non-depressed subjects, no significant correlation was observed between plasma and CSF levels of these compounds.ConclusionThese data give the first indication that decreased plasma levels of Asp, Gly and GABA and increased NO levels may serve as a clinical trait-marker for melancholic MDD. The specificity and selectivity of this putative trait-marker has to be investigated in follow-up studies.

show abstract

“…There is no difference between subjects; the frequencies are similar for controls and MDD patients [49]. In an autopsy and tissue bank-based study from Holland, there is decrease in nNOS expression in the anterior cingulate cortex of MDD-diagnosed people [50].…”

Section: Roles Of Noss In Neuropsychiatric Diseasesmentioning

confidence: 85%

Role of Nitric Oxide Synthase in Normal Brain Function and Pathophysiology of Neural Diseases

Dagdeviren¹

2017

Nitric Oxide Synthase - Simple Enzyme-Complex Roles

View full text Add to dashboard Cite

Nitric oxide synthase has three isoforms; according to their roles and tissues or cells they are involved. Neuronal NOS (nNOS) takes place in neuronal signalling, endothelial NOS (eNOS) takes place in vasodilation and inducible NOS (iNOS) takes place in immune responses. nNOS and eNOS are dominant but all isoforms have various roles in the central nervous system. nNOS and eNOS separately or together works in healthy brain during cognitive processes and in unhealthy brain during the pathology of related diseases. These roles were shown by inhibitor applied or by transgenic animal model studies and also by investigating the diseases at the molecular level. Besides, it is possible to say that iNOS has roles in some neurological pathologies creating immune responses. Three different isoforms mainly serve in different systems so there are lots of researchers from various disciplines working collaterally not knowing the others related works about NOSs. Because of this, a comprehensive chapter will be valuable for neuroscientists working with either healthy or unhealthy brains. The purpose of this chapter is to gather an overview of NOSs duties during the normal processes of the brain like learning and memory formation and abnormal processes such as depression, schizophrenia and brain cancers.

show abstract

Decreased NOS1 Expression in the Anterior Cingulate Cortex in Depression

Cited by 57 publications

References 73 publications

Neuronal Nitric Oxide Synthase (NOS1) Polymorphisms Interact with Financial Hardship to Affect Depression Risk

Neuronal Nitric Oxide Synthase (NOS1) Polymorphisms Interact with Financial Hardship to Affect Depression Risk

Decreased plasma neuroactive amino acids and increased nitric oxide levels in melancholic major depressive disorder

Role of Nitric Oxide Synthase in Normal Brain Function and Pathophysiology of Neural Diseases

Contact Info

Product

Resources

About