Decreased melanoma CSF-1 secretion by Cannabigerol treatment reprograms regulatory myeloid cells and reduces tumor progression

Wyrobnik, Iris; Steinberg, Miryam; Gelfand, Anat; Rosenblum, Ronen; Eid Mutlak, Yara; Sulimani, Liron; Procaccia, Shiri; Ofran, Yishai; Novak-Kotzer, Hila; Meiri, David

doi:10.1080/2162402x.2023.2219164

OncoImmunology

2023

DOI: 10.1080/2162402x.2023.2219164

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Decreased melanoma CSF-1 secretion by Cannabigerol treatment reprograms regulatory myeloid cells and reduces tumor progression

Iris Wyrobnik,

Miryam Steinberg,

Anat Gelfand

et al.

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Cited by 3 publications

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The intricate dance of tumor evolution: Exploring immune escape, tumor migration, drug resistance, and treatment strategies

Guo,

Bian,

et al. 2024

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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The intricate dance of tumor evolution: Exploring immune escape, tumor migration, drug resistance, and treatment strategies

Guo,

Bian,

et al. 2024

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Supporting gut health with medicinal cannabis in people with advanced cancer: potential benefits and challenges

Wardill,

Wooley,

Bellas

et al. 2023

Br J Cancer

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The side effects of cancer therapy continue to cause significant health and cost burden to the patient, their friends and family, and governments. A major barrier in the way in which these side effects are managed is the highly siloed mentality that results in a fragmented approach to symptom control. Increasingly, it is appreciated that many symptoms are manifestations of common underlying pathobiology, with changes in the gastrointestinal environment a key driver for many symptom sequelae. Breakdown of the mucosal barrier (mucositis) is a common and early side effect of many anti-cancer agents, known to contribute (in part) to a range of highly burdensome symptoms such as diarrhoea, nausea, vomiting, infection, malnutrition, fatigue, depression, and insomnia. Here, we outline a rationale for how, based on its already documented effects on the gastrointestinal microenvironment, medicinal cannabis could be used to control mucositis and prevent the constellation of symptoms with which it is associated. We will provide a brief update on the current state of evidence on medicinal cannabis in cancer care and outline the potential benefits (and challenges) of using medicinal cannabis during active cancer therapy.

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Macrophage colony-stimulating factor and its role in the tumor microenvironment: novel therapeutic avenues and mechanistic insights

Yi,

Gai,

Chen

et al. 2024

Front. Oncol.

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The tumor microenvironment is a complex ecosystem where various cellular and molecular interactions shape the course of cancer progression. Macrophage colony-stimulating factor (M-CSF) plays a pivotal role in this context. This study delves into the biological properties and functions of M-CSF in regulating tumor-associated macrophages (TAMs) and its role in modulating host immune responses. Through the specific binding to its receptor colony-stimulating factor 1 receptor (CSF-1R), M-CSF orchestrates a cascade of downstream signaling pathways to modulate macrophage activation, polarization, and proliferation. Furthermore, M-CSF extends its influence to other immune cell populations, including dendritic cells. Notably, the heightened expression of M-CSF within the tumor microenvironment is often associated with dismal patient prognoses. Therefore, a comprehensive investigation into the roles of M-CSF in tumor growth advances our comprehension of tumor development mechanisms and unveils promising novel strategies and approaches for cancer treatment.

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Decreased melanoma CSF-1 secretion by Cannabigerol treatment reprograms regulatory myeloid cells and reduces tumor progression

Cited by 3 publications

References 53 publications

The intricate dance of tumor evolution: Exploring immune escape, tumor migration, drug resistance, and treatment strategies

The intricate dance of tumor evolution: Exploring immune escape, tumor migration, drug resistance, and treatment strategies

Supporting gut health with medicinal cannabis in people with advanced cancer: potential benefits and challenges

Macrophage colony-stimulating factor and its role in the tumor microenvironment: novel therapeutic avenues and mechanistic insights

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