Decreased Maternal Serum Leptin in Pregnancies Complicated by Preeclampsia

Laml, Thomas; Preyer, Oliver; Hartmann, Beda; Ruecklinger, E.; Soeregi, Gabor; Wagenbichler, P

doi:10.1177/107155760100800205

Cited by 30 publications

(24 citation statements)

References 20 publications

(2 reference statements)

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“…They reported that this observation could be due to the intimately linked nutritional status in the mother and fetus that could affect fat mass and circulating insulin levels which, in turn, would influence their leptin concentrations. In contrast, some studies have indicated no correlation between maternal and newborn leptin concentrations (14,17). We found a statistically significant correlation between maternal and cord leptin levels in SGA newborns but not in other groups, which is in agreement with the previously reported positive relationship between maternal and cord leptin levels.…”

Section: Discussionsupporting

confidence: 53%

Correlation between birth weight, leptin, zinc and copper levels in maternal and cord blood

Özdemir

Gültürk

Aker

et al. 2007

J. Physiol. Biochem.

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Leptin and zinc are involved in the regulation of appetite. Copper is a trace element regulating the functions of several cuproenzymes that are essential for life. To evaluate the relationship between zinc and copper status and the leptin system in humans, we examined whether leptin concentrations in the mother and the newborn correlate with the weight of mother, placenta and newborn. A total of 88 pregnant women at 38-42 weeks' gestation were studied. All infants were categorized as small for gestational age (SGA) (n = 16), average for gestational age (AGA) (n = 59) or large for gestational age (LGA) (n = 13). Leptin, zinc, and copper levels were measured in maternal and cord serum at birth. Maternal BMI and placental weight of the LGA groups were significantly higher than those of the SGA and AGA groups. Cord and maternal leptin levels of the SGA groups were significantly lower than those of the AGA and LGA groups. Maternal serum leptin levels were positively correlated with BMI and maternal zinc levels in all groups. Cord serum leptin levels of all groups were positively correlated with birth weight and placental weight. Birth weight was negatively correlated with maternal and cord copper level of all groups. Umbilical leptin concentrations of SGA newborns correlated with leptin concentrations of their mothers. In all pregnancies, birth weight increases in association with increase in cord leptin level. Our results suggest that maternal zinc but not copper level has an effect on maternal serum leptin levels. The increase in copper level in both maternal and cord blood may contribute to restriction in fetal growth.

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Section: Discussionsupporting

confidence: 53%

Correlation between birth weight, leptin, zinc and copper levels in maternal and cord blood

Özdemir

Gültürk

Aker

et al. 2007

J. Physiol. Biochem.

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“…The majority of studies have reported increased serum leptin levels and increased placental leptin expression in pregnancies with PE compared with normotensive pregnancies (10,11,34). However, conflicting results have also been reported (31,32,40). The present study demonstrated that the expression of placental bed leptin and HIF-1α were significantly elevated in pregnancies with PE compared with the normotensive control group.…”

Section: Discussionsupporting

confidence: 40%

“…A number of studies have investigated leptin levels in maternal serum, cord blood and placental tissue in patients with or without PE (10,11,(31)(32)(33)(34)(35). The majority of studies have reported increased serum leptin levels and increased placental leptin expression in pregnancies with PE compared with normotensive pregnancies (10,11,34).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies on expression of leptin, leptin receptor and HIF-1α during pregnancy are limited in the placental tissue and serum and to the best of the authors knowledge, no studies have been conducted using placental bed (10,11,(31)(32)(33)(34)(35). Currently, to the best of our knowledge, no previous studies have investigated the expression of these factors in the placental bed of women with PE.…”

Section: Introductionmentioning

confidence: 99%

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Leptin, leptin receptors and hypoxia-induced factor-1α expression in the placental bed of patients with and without preeclampsia during pregnancy

et al. 2018

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The mechanism underlying the pathogenesis of preeclampsia (PE) has been previously investigated but remains to be elucidated. Among numerous biomarkers that are associated with the pathogenesis of PE, leptin is most frequently investigated. Although studies concerning the association between PE and the expression of leptin in the serum and placenta have been conducted, the results are conflicting and inconsistent. Furthermore, the expression of leptin and its receptors in the placental bed and their association with PE, to the best of our knowledge, has not been previously reported. Therefore, to determine the association between the expression of leptin and its receptor, and pathogenesis and onset period of PE, placental bed tissues were obtained from cesarean section deliveries. The mRNA and protein expression levels of leptin and its receptor were investigated in normal pregnancies (n=18), pregnancies complicated with early‑onset PE (n=9) and late‑onset PE (n=9) by reverse transcription‑quantitative polymerase chain reaction and western blotting, respectively. The results demonstrated that the mRNA and protein expression of leptin in the placental bed was significantly increased in the PE groups compared with normal controls and was associated with the onset period of PE. Furthermore, as evidenced by immunostaining, leptin was upregulated in endothelial cells of the placental bed in the PE groups, with a particularly strong upregulation in activated endothelial cells from patients with early‑onset PE. The results of the present study indicate that altered expression of leptin in the placental bed may contribute to the pathogenesis of PE.

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“…The most obvious question is whether the concentration of leptin is abnormal in the mothers' blood in a preeclamptic pregnancy. Several studies have attempted to answer this 16,[26][27][28][29][30][31][32][33][34] ; indeed, there is at present little more information available other than straightforward assessment of maternal plasma or serum leptin concentrations. Some additional information is derived from two investigations of placental leptin expression, 25,26 and others have measured cord blood leptin concentrations.…”

Section: Concentrations Of Leptin In Maternal Bloodmentioning

confidence: 99%

Leptin and Preeclampsia

Poston¹

2002

Semin Reprod Med

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Preeclampsia, a common complications of pregnancy, is associated with an increase in the concentration of leptin in the maternal blood, which precedes the clinical onset of the disease. This review addresses the potential sources of leptin and considers the possible consequences, although at present these are entirely conjectural. The placenta is likely to contribute to the rise in leptin, and placental hypoxia and inflammatory mediators may be important stimuli. The possible protective and damaging sequelae of an increase in the maternal leptin concentrations may range from beneficial stimulation of fetal growth to an increase in blood pressure through stimulation of sympathetic activity. Further research is needed to determine if the rise in leptin plays a role in preeclampsia or whether it is a secondary and unrelated bystander.

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Decreased Maternal Serum Leptin in Pregnancies Complicated by Preeclampsia

Cited by 30 publications

References 20 publications

Correlation between birth weight, leptin, zinc and copper levels in maternal and cord blood

Correlation between birth weight, leptin, zinc and copper levels in maternal and cord blood

Leptin, leptin receptors and hypoxia-induced factor-1α expression in the placental bed of patients with and without preeclampsia during pregnancy

Leptin and Preeclampsia

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