Decreased levels of urinary di-2-ethylhexyl phthalate (DEHP) metabolites and biomarkers of oxidative stress in children exposed to DEHP-tainted foods in Taiwan in 2011: A 44-month follow-up

Hsiung, Chao A.; Tsai, Hung-Chin; Cheng, Ching-Mei; Chen, Bai-Hsiun; Hu, Chiung‐Wen; Huang, Yeou‐Lih; Wu, Ming‐Tsang

doi:10.1016/j.envpol.2020.115204

Cited by 9 publications

(4 citation statements)

References 63 publications

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“…Recent studies have proposed an association between PAEs metabolites and nucleic acid oxidation products (Pigini et al, 2022; Wu et al, 2020). The imbalance between prooxidants and antioxidants may lead to many reproductive system problems, such as lower follicular mass, endometriosis, polycystic ovary syndrome (PCOS), and unexplained infertility (Agarwal et al, 2008; Tatone et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Relationship between phthalates exposure, risk of decreased ovarian reserve, and oxidative stress levels

Hu,

Jin,

Wang

et al. 2024

Toxicol Ind Health

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Phthalates (PAEs), a group of environmental endocrine disruptors, are associated with oxidative stress and have adverse effects on female ovarian reserves. However, this association has been poorly investigated, particularly with respect to clinical evidence. In this study, we provided clinical evidence of a relationship between exposure levels of PAEs, oxidative stress and decreased ovarian reserve (DOR). Firstly, the urinary concentrations of metabolites of PAEs were measured by high performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS). The serum concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and anti-Mullerian hormone (AMH), and the biomarkers of oxidative stress, malondialdehyde (MDA), superoxide dismutase (SOD), and total antioxidant capacity (T-AOC), were determined. Finally, statistical analyses were conducted to describe the relationship between the PAEs exposure, oxidative stress and DOR. We found that the levels of monomethyl phthalate (MMP), monoisobutyl phthalate (MiBP), mono-(2-ethylhexyl) phthalate (MEHP), and mono-(2-ethyl-5-hydroxypentyl) phthalate (MECPP) in the DOR group were significantly higher than those in the control group. There was a significant negative association between AMH and MMP, MiBP levels. and a significant positive association between FSH and MMP levels. PAEs exposure was also associated with a significant increase in MDA levels and decrease in SOD levels. In conclusion, the exposure of PAEs was closely associated with DOR, potentially mediated by oxidative stress pathways; however, small sample size was a limitation in this study.

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Section: Discussionmentioning

confidence: 99%

Relationship between phthalates exposure, risk of decreased ovarian reserve, and oxidative stress levels

Hu,

Jin,

Wang

et al. 2024

Toxicol Ind Health

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“…In 2011, Lin et al [ 42 ] reported the level of DEHP metabolites in breast milk in Taiwan; however, the levels of DEHP metabolites were relatively low in human milk in the present study. It is possible that people in Taiwan have become more aware about avoiding phthalate exposure through the purchase and intake of food products, and illegal phthalate addition in foods has been found and prohibited by the government following the Taiwan food scandal in 2011 [ 30 , 43 ].…”

Section: Discussionmentioning

confidence: 99%

“…Due to the phthalate incident in 2011 [ 43 ], Taiwanese people are now concerned about whether the body burden of phthalate has decreased since the incident. Thus, we compared our findings with those from the 2011 study concerning phthalate exposure in human milk in Taiwan [ 42 ] and found that, although the detection rates in the present study seem higher than those in Lin et al’s study [ 42 ], the levels of MEHP have significantly decreased during these years, suggesting that Taiwanese people have developed increased awareness of the safety of food, and DEHP contamination in foodstuffs appears to have been controlled by the Taiwan government.…”

Section: Discussionmentioning

confidence: 99%

Phthalate Exposure Pattern in Breast Milk within a Six-Month Postpartum Time in Southern Taiwan

Hung

Lin

Suen

et al. 2021

IJERPH

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Di-(2-ethylhexyl) phthalate (DEHP), a common plasticizer, has been detected in breast milk in many countries; however, whether phthalate metabolite concentration and the detection rate in breast milk change postpartum is still unknown. We measured phthalate metabolite concentrations in breast milk in the first 6 months postpartum in women enrolled in the E-Da hospital from January to July 2017. A total of 56 breastfeeding mothers and 66 samples were included in this study. We analyzed the samples’ concentration of eight phthalate metabolites using liquid chromatography mass spectrometry. The concentration of mono-2-ethylhexyl phthalate (MEHP) was significantly higher in the first month, and then decreased over time. The detection rate of ono-isobutyl phthalate (MiBP) and mono-n-butyl phthalate (MBP) was low in the first month and then increased over time. Compared with a previous study published in 2011, the levels of MEHP and MiBP in breast milk were much lower in the present study, suggesting an increased awareness of the health risks of phthalate exposure after a food scandal occurred in Taiwan. This study provides information for evaluating newborns’ exposure to different kinds of phthalate through human milk in the postpartum period.

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“…In Taiwan, phthalates, including DEHP, have been identified in the human body [ 15 , 16 ], food [ 17 ], and soil [ 18 ]. Nevertheless, a notable gap persists in establishing the threshold for DEHP exposure in the context of asthma disease.…”

Section: Introductionmentioning

confidence: 99%

Increased di-(2-ethylhexyl) phthalate exposure poses a differential risk for adult asthma clusters

Hsu,

Wu,

Wang

et al. 2024

Respir Res

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Background DEHP, a common plasticizer known for its hormone-disrupting properties, has been associated with asthma. However, a significant proportion of adult asthma cases are “non-atopic”, lacking a clear etiology. Methods In a case-control study conducted between 2011 and 2015, 365 individuals with current asthma and 235 healthy controls from Kaohsiung City were enrolled. The control group comprised individuals without asthma, Type 2 Diabetes Mellitus (T2DM), hypertension, or other respiratory/allergic conditions. The study leveraged asthma clusters (Clusters A to F) established in a prior investigation. Analysis involved the examination of urinary DEHP metabolites (MEHP and MEHHP), along with the assessment of oxidative stress, sphingolipid metabolites, and inflammatory biomarkers. Statistical analyses encompassed Spearman’s rank correlation coefficients, multiple logistic regression, and multinomial logistic regression. Results Asthma clusters (E, D, C, F, A) exhibited significantly higher ORs of MEHHP exposures compared to the control group. When considering asthma-related comorbidities (T2DM, hypertension, or both), patients without comorbidities demonstrated significantly higher ORs of the sum of primary and secondary metabolites (MEHP + MEHHP) and MEHHP compared to those with asthma comorbidities. A consistent positive correlation between urinary HEL and DEHP metabolites was observed, but a consistent negative correlation between DEHP metabolites and selected cytokines was identified. Conclusion The current study reveals a heightened risk of MEHHP and MEHP + MEHHP exposure in specific asthma subgroups, emphasizing its complex relationship with asthma. The observed negative correlation with cytokines suggests a new avenue for research, warranting robust evidence from epidemiological and animal studies.

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Decreased levels of urinary di-2-ethylhexyl phthalate (DEHP) metabolites and biomarkers of oxidative stress in children exposed to DEHP-tainted foods in Taiwan in 2011: A 44-month follow-up

Cited by 9 publications

References 63 publications

Relationship between phthalates exposure, risk of decreased ovarian reserve, and oxidative stress levels

Relationship between phthalates exposure, risk of decreased ovarian reserve, and oxidative stress levels

Phthalate Exposure Pattern in Breast Milk within a Six-Month Postpartum Time in Southern Taiwan

Increased di-(2-ethylhexyl) phthalate exposure poses a differential risk for adult asthma clusters

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