Decreased levels of coenzyme Q₁₀ in patients with bronchial asthma

Abstract

Results of the study suggest a possible contribution of suboptimal concentrations of CoQ10 on antioxidative dysbalance in As and provide a rationale for its supplementation.

Elevated plasma glutathione peroxidase concentration in acute severe asthma: Comparison with plasma glutathione peroxidase activity, selenium and malondialdehyde

“…The MDA levels were not elevated when compared with other studies; however, there appears to be significant variability in normal levels between groups, which makes comparisons difficult [27][28][29]. Measurement of the MDA-TBA (malondialdehyde-thiobarbituric acid) adduct is the most widely used method for evaluating lipid peroxidation and was chosen as the biomarker for oxidative stress in this study due to the relative stability.…”

Acquired coenzyme Q10 deficiency in children with recurrent food intolerance and allergies

“…However, there is growing evidence that secondary or acquired CoQ10 deficiency may be much more common than primary deficiency. Low levels of CoQ10 in plasma and serum have been reported in a number of disorders, including phenylketonuria (PKU) (Artuch et al, 1999), asthma (Gazdík et al, 2002), migraine headaches (Hershey et al, 2007), Friedreich's ataxia (Cooper et al, 2008), cystic fibrosis (Laguna et al, 2008), and congestive heart failure (Molyneux et al, 2008). However, none of these reports was able to conclusively demonstrate the presence of CoQ10 deficiency by evaluation of CoQ10 content in tissue.…”

Nourishing and health benefits of coenzyme Q₁₀

“…CoQ 10 may be helpful in the treatment of respiratory diseases, especially asthma. Gazdík et al (2002) described significantly decreased levels of CoQ 10 and α-tocopherol both in plasma and blood in patients with bronchial asthma, as compared with healthy subjects. Gvozdjáková et al (2005) did a study which showed that patients with corticosteroid-dependent bronchial asthma had low plasma CoQ 10 concentrations which might contribute to their antioxidant imbalance and oxidative stress.…”