Decreased leukocyte recruitment in the mesenteric microcirculation of rats with cirrhosis is partially restored by treatment with peginterferon: An in vivo study

Geerts, Anja; Cheung, Kin-Jip; Vlierberghe, Hans Van; Vriese, An S. De; Mortier, Siska; Vanheule, Eline; Lameire, Norbert; Vos, Martine De; Colle, Isabelle

doi:10.1016/j.jhep.2006.11.014

Cited by 4 publications

(2 citation statements)

References 41 publications

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“…These include defective opsonization, e.g. via deficiencies in complement C3 (3, 4), defective chemotaxis (5), reduced production of superoxide anion, oxidative burst and bacterial killing capacity (6, 7). Advances in antibiotic treatment and hospital care have failed to decrease the fatality rate of bacterial infections in advanced cirrhosis, pointing out the need for a better understanding of the underlying mechanisms of the disease, in order to explore new treatment strategies.…”

mentioning

confidence: 99%

Bacterial translocation increases phagocytic activity of polymorphonuclear leucocytes in portal hypertension: priming independent of liver cirrhosis

Neugebauer

Hartmann

Krenn

et al. 2008

Liver International

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mentioning

confidence: 99%

Bacterial translocation increases phagocytic activity of polymorphonuclear leucocytes in portal hypertension: priming independent of liver cirrhosis

Neugebauer

Hartmann

Krenn

et al. 2008

Liver International

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“…Severe hepatic inflammation or fibrosis is considered as an essential condition in HCV-related HCC [Heathcote, 2004]. Common bile duct ligation usually causes significant hepatic inflammation and subsequent hepatic fibrosis or cirrhosis in experimental animals [Geerts et al, 2007]. The use of HCV core transgenic mice with robust HCV core expression and common bile duct ligation, therefore, provides a suitable model that mimics the clinical situation, thus allowing the analysis of HCV-related hepatocarcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

Cell cycle perturbation in the hepatocytes of HCV core transgenic mice following common bile duct ligation is associated with enhanced p21 expression

Chang

Chen

Chang

et al. 2009

Journal of Medical Virology

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Hepatitis C virus (HCV) core protein has been reported to alter the cell cycle in vitro, but the data remain inconclusive, and in vitro experiments do not represent precisely events that occur in vivo, which may involve hepatic inflammation or regeneration. A group of double-transgenic mice carrying tetracycline transactivator (tTA) and HCV core that express conditionally the HCV core in the mature liver, and single-transgenic mice carrying only tTA were subjected to sham laparotomy, 43% partial hepatectomy, or common bile duct ligation. The cell cycle markers, including cyclin A, B1, D, E1, Mcm-2, phosphorylated histone 3 protein, Ki67, and p21Waf1/Cip1/Sdi1 (p21), were evaluated in liver samples obtained 3 days after the operation. No significant differences in the levels of any markers were observed between the double- and single-transgenic mice following sham laparotomy. Among the mice that underwent common bile duct ligation, the double-transgenic mice had lower levels of Ki67 (P = 0.0001), higher levels of cyclin D1 (P = 0.0001), and higher levels of p21 expression than the single-transgenic mice. Among those that underwent partial hepatectomy, the double-transgenic mice had higher p21 expression levels, but no significant differences in the levels of any other markers were observed between the double- and single-transgenic mice. It is concluded that the HCV core alters the hepatocyte cell cycle in addition to inducing G1 arrest in vivo after common bile duct ligation, and is associated with enhanced p21 expression. This may account at least partially for the strong association between HCV-related hepatocarcinogenesis and hepatic inflammation/ fibrosis.

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Thalidomide decreases intrahepatic resistance in cirrhotic rats

Yang

Huang²,

Lin

et al. 2009

Biochemical and Biophysical Research Communications

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Decreased leukocyte recruitment in the mesenteric microcirculation of rats with cirrhosis is partially restored by treatment with peginterferon: An in vivo study

Cited by 4 publications

References 41 publications

Bacterial translocation increases phagocytic activity of polymorphonuclear leucocytes in portal hypertension: priming independent of liver cirrhosis

Bacterial translocation increases phagocytic activity of polymorphonuclear leucocytes in portal hypertension: priming independent of liver cirrhosis

Cell cycle perturbation in the hepatocytes of HCV core transgenic mice following common bile duct ligation is associated with enhanced p21 expression

Thalidomide decreases intrahepatic resistance in cirrhotic rats

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