Decreased interstitial cells of Cajal in the sigmoid colon of patients with slow transit constipation

Tong, Weidong; Liu, Baohua; Zhang, Lianyang; Zhang, Sheng-Ben; Lei, Ying

doi:10.1007/s00384-003-0577-x

Cited by 65 publications

(45 citation statements)

References 32 publications

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“…We (Tong et al 2004) and others (He et al 2001;Feldstein et al 2003) have confirmed the discovery of the loss of ICC within a number of human GI motility disorders, including slow transit constipation, diabetic enteropathy, and pseudo-obstruction etc. In several models of ICC injury, the loss of ICC and gut motility is severe, but restoration can take place within weeks.…”

Section: Discussionsupporting

confidence: 53%

Hydrogen Sulfide, a Gaseous Transmitter, Stimulates Proliferation of Interstitial Cells of Cajal via Phosphorylation of AKT Protein Kinase

Huang

Tong

et al. 2010

Tohoku J. Exp. Med.

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Section: Discussionsupporting

confidence: 53%

Hydrogen Sulfide, a Gaseous Transmitter, Stimulates Proliferation of Interstitial Cells of Cajal via Phosphorylation of AKT Protein Kinase

Huang

Tong

et al. 2010

Tohoku J. Exp. Med.

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“…108 The etiology of this disorder is poorly understood and recent investigations have focused on neural mechanisms, including a decrease in interstitial cells of Cajal. 109,110 Investigators have also evaluated other potential mechanisms, including proto-oncogenes, tyrosine kinase C, autonomic neuropathy, overexpression of progesterone receptors, infectious agents, autoimmunity, medications, as well as gut hormones. [111][112][113][114][115][116][117][118][119][120] A number of studies suggest that alterations in 5-HT signaling may contribute to the symptoms of chronic constipation, but again, inconsistencies exist among these investigations (Table 2).…”

Section: Chronic Constipationmentioning

confidence: 99%

Serotonin and Its Role in Colonic Function and in Gastrointestinal Disorders

Costedio¹,

Hyman²,

Mawe³

2007

Diseases of the Colon &Amp; Rectum

152

131

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Serotonin (5-HT) is most commonly thought of as a neurotransmitter in the central nervous system. However, the predominant site of serotonin synthesis, storage, and release is the enterochromaffin cells of the intestinal mucosa. Within the intestinal mucosa, serotonin released from EC cells activates neural reflexes associated with intestinal secretion, motility, and sensation. Two important receptors for serotonin that are located in the neural circuitry of the intestines are the 5-HT(3) and 5-HT(4) receptors; these are the targets of drugs designed to treat gastrointestinal disorders. 5-HT(3) receptor antagonists are used to treat nausea and emesis associated with chemotherapy and for functional disorders associated with diarrhea. 5-HT(4) receptor agonists are used as promotility agents to promote gastric emptying and to alleviate constipation. Because of the importance of serotonin in normal gut function and sensation, a number of studies have investigated potential changes in mucosal serotonin signaling in pathologic conditions. Despite the inconsistencies in the current literature, changes in serotonin signaling have now been demonstrated in inflammatory bowel disease, irritable bowel syndrome, postinfectious irritable bowel syndrome, and idiopathic constipation. Emerging evidence has led to many contradictory theories regarding serotonin signaling and its roles in the pathology of gut disorders. This review summarizes the current medications affecting serotonin signaling and provides an overview of our current knowledge of the changes in serotonin that occur in pathologic conditions.

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“…Their findings suggest that excessive and uncoordinated phasic rectal activity may further impede stool transport and contribute to STC [40] .…”

Section: Physiology Of Dysmotilitymentioning

confidence: 99%

Pathophysiology of constipation in the older adult

McCrea¹,

Miaskowski²,

Stotts³

et al. 2008

WJG

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Decreased interstitial cells of Cajal in the sigmoid colon of patients with slow transit constipation

Abstract: Similar distribution of ICC was observed in the normal sigmoid colon of the Chinese. Decreased area of c-kit+ ICC may play an important role in the pathophysiology of STC. It remains to be determined whether the loss of ICC is primary or secondary to another lesion.

Cited by 65 publications

References 32 publications

Hydrogen Sulfide, a Gaseous Transmitter, Stimulates Proliferation of Interstitial Cells of Cajal via Phosphorylation of AKT Protein Kinase

Hydrogen Sulfide, a Gaseous Transmitter, Stimulates Proliferation of Interstitial Cells of Cajal via Phosphorylation of AKT Protein Kinase

Serotonin and Its Role in Colonic Function and in Gastrointestinal Disorders

Pathophysiology of constipation in the older adult

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