Decreased interleukin 10 and increased interferon-γ production in patients with chronic graft-versus-host disease after allogeneic bone marrow transplantation

Körholz, Dieter; Kunst, D; Hempel, Lutz; Söhngen, D; Heyll, A.; Bönig, Halvard; Göbel, U.; Zintl, F; Burdach, Stefan

doi:10.1038/sj.bmt.1700718

Cited by 53 publications

(35 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…19,22 On the other hand, other studies favor a Th1-driven mechanism of cGVHD in both murine and human systems. [23][24][25] However, the current study could not detect any significant difference in IL-4 or IFN-g production from CD4 þ T cells between patients with and without cGVHD. Although the reason for the discrepancy in the results between the previous reports and this study is currently unknown, it might be related to the difference in the severity of cGVHD examined.…”

Section: Discussioncontrasting

confidence: 44%

“…20 In addition, several reports have demonstrated that type 2 cytokines are associated with cGVHD, 21,22 whereas other studies favor the significance of Th1 balance in cGVHD. [23][24][25][26] In this study, we analyzed the cytokine production of T cells in the chronic phase of patients who underwent allo-HSCT and found that IL-4-producing CD8 þ T cells are closely associated with cGVHD.…”

Section: Gvhd; Hsct; Cytokinesmentioning

confidence: 99%

See 1 more Smart Citation

IL-4-producing CD8+ T cells may be an immunological hallmark of chronic GVHD

Nakamura

Amakawa

Takebayashi

et al. 2005

Bone Marrow Transplant

View full text Add to dashboard Cite

Summary:Chronic graft-versus-host disease (cGVHD) occurs in approximately 60-80% of those who survive over 100 days after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, the pathophysiology of cGVHD is poorly understood. To gain more insight into the immunological mechanism of cGVHD, we examine cytokine production of peripheral blood T cells from 19 patients in the chronic phase of allo-HSCT. The percentage of IFN-c-producing CD8 þ T cells among CD8 þ T cells was significantly higher in patients with or without cGVHD than in normal control subjects (Po0.001). On the other hand, the percentage of IL-4-producing CD8 þ T cells among CD8 þ T cells was significantly higher in patients with cGVHD (mean 3.3%; range 1.3-8.2%) than in patients without cGVHD (mean 1.2%; range 0.8-1.7%) and normal control subjects (mean 1.1%; range 0.1-1.6%) (both Po0.001). By contrast, the percentage of IL-4-producing CD4 þ T cells was not different among patients with and without cGVHD and normal controls. These findings suggest that IL-4-producing CD8 þ T cells may be an immunological marker of cGVHD.

show abstract

Section: Discussioncontrasting

confidence: 44%

Section: Gvhd; Hsct; Cytokinesmentioning

confidence: 99%

IL-4-producing CD8+ T cells may be an immunological hallmark of chronic GVHD

Nakamura

Amakawa

Takebayashi

et al. 2005

Bone Marrow Transplant

View full text Add to dashboard Cite

show abstract

“…30 It was observed in a murine cGVHD model that production of Th2 cytokines was enhanced and Th1 cytokines impaired, suggesting that activation of Th2 cells is responsible for autoantibody formation and immunosuppression in cGVHD. 31 However, Körholz et al 32 reported a significant decrease in IL-10 production by mononuclear cells activated in vitro in cGVHD patients. It is not clear whether this discrepancy is due to a different pathogenesis of human cGVHD and murine cGVHD, or to a difference in the method of testing serum samples or samples from cells activated in vitro.…”

Section: Discussionmentioning

confidence: 99%

Contribution of TNF-α and IL-10 gene polymorphisms to graft-versus-host disease following allo-hematopoietic stem cell transplantation

Takahashi

Furukawa

Hashimoto

et al. 2000

Bone Marrow Transplant

View full text Add to dashboard Cite

Summary:Some cytokines are believed to play a role in the development of acute and chronic GVHD after allo-hematopoietic stem cell transplantation. It has been reported that TNF-␣ and IL-10 gene polymorphisms are associated with the production of those cytokines and the development of graft failure after organ transplantation and systemic lupus erythematosus. We examined whether TNF-␣ and IL-10 gene polymorphisms affect the severity of acute GVHD (aGVHD) and chronic GVHD (cGVHD). Sixty-two and 54 patients were available for the analysis of aGVHD and cGVHD, respectively. We analyzed the gene polymorphisms derived from preand post-transplant blood cells. Donor-derived TNF2 allele (A) was more frequently detected in patients with aGVHD III/IV than those aGVHD 0-II (2/6 vs 2/56) (P ‫؍‬ 0.04). The donors of the patients with cGVHD more frequently possessed a greater number of alleles (allele 13 or more which contain 26 or more CA repeats) in IL-10·G than those without (13/26 vs 5/28) (P ‫؍‬ 0.02), and the patients with cGVHD had more CA repeats in donor-derived IL-10·G than those without (mean ‫؍‬ 25.2 vs 23.4) (P ‫؍‬ 0.01). Donor-derived TNF-308 and IL-10·G alleles may contribute to severe aGVHD and cGVHD, respectively, and will help us distinguish those patients at high risk for GVHD. Bone Marrow Transplantation (2000) 26, 1317-1323.

show abstract

“…51 Chronic GVHD has been proposed by Ferrara and colleagues 52 to be a Th2-mediated disease, but recent studies demonstrating upregulation of Th1 cytokines IFN␥ and IL-12 in peripheral blood mononuclear cells implicate, in part, a Th1-driven mechanism similar to that seen in acute alloreactivity. 49,52,53 To elucidate the immunomodulatory effects of ECP on putative effectors of cGVHD, we initiated a clinical trial to evaluate lymphocyte and dendritic cell function in patients receiving ECP for 2 consecutive days every 2 weeks. 54 The median time from BMT in our population was 667 days (range, 101-600 days).…”

Section: Immunomodulatory Mechanisms Of Ecp In Gvhdmentioning

confidence: 99%