Decreased interhemispheric resting-state functional connectivity in first-episode, drug-naive major depressive disorder

Guo, Wenbin; Liu, Feng; Dai, Yi; Jiang, Muliang; Zhang, Jian; Yu, Liuyu; Long, Liling; Chen, Huafu; Gao, Qing; Xiao, Changfu

doi:10.1016/j.pnpbp.2012.11.003

Cited by 126 publications

(106 citation statements)

References 48 publications

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“…However, there were no brain regions showing altered resting-state functional connectivity with the left thalamus as seed in the OCD patients. Previous researches found that the left and right brain regions with changed VMHC values showed different resting-state functional connectivity pattern [22], and the left and right thalamus may have diverse whole-brain functional connectivity patterns in Alzheimer's disease [45]. Based on the present research results, we infer that the left and right thalamus with changed VMHC values may also have different functional connectivity pattern at resting-state in OCD patients.…”

Section: Research Ping LIsupporting

confidence: 65%

“…A new measure, voxel-mirrored homotopic connectivity (VMHC), can quantify the homotopic patterns of RSFC by providing a voxelwise measure of connectivity between each voxel in one brain hemisphere and its mirrored voxel in the other [17]. Recently, the VMHC method has provided a variety of new disease-related findings on functional homology in cocaine addiction [15], schizophrenia [21], major depressive disorder [22,23], bipolar II disorder [24], autism [25] and drug-naive somatization disorder [26]. These findings demonstrate that VMHC can be regarded as a reliable and feasible measure to detect alterations in the functional homology between cerebral hemispheres in OCD patients.…”

Section: Subjectsmentioning

confidence: 99%

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Reduced Interhemispheric Resting-State Functional Homotopy in Obsessive-Compulsive Disorder

Wang¹,

Chen²,

Li³

et al. 2018

Neuropsychiatry

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Neuroimaging studies have shown structural and functional abnormalities in parts of the cortico-striato-thalamo-cortical (CSTC) brain circuitry in patients with obsessive-compulsive disorder (OCD). However, little is known about changes in the interhemispheric functional homotopy in the resting-state in OCD. This study used a voxel-mirrored homotopic connectivity (VMHC) approach combined with resting-state functional magnetic resonance imaging to investigate changes in interhemispheric functional homotopy in 60 OCD patients and 60 healthy controls. Compared with the healthy controls, the OCD patients showed decreased VMHC values in the thalamus. The results suggest that changes in functional homotopy in the CSTC circuitry may be involved in the pathophysiologic mechanism of OCD. Our findings provide new evidence of abnormalities in the CSTC circuitry in OCD.

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Section: Research Ping LIsupporting

confidence: 65%

Section: Subjectsmentioning

confidence: 99%

Reduced Interhemispheric Resting-State Functional Homotopy in Obsessive-Compulsive Disorder

Wang¹,

Chen²,

Li³

et al. 2018

Neuropsychiatry

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“…However, DMN regions tend to show increased connectivity during early phases of mild cognitive impairment followed by decreased connectivity later on (27,28). Both increased and decreased DMN connectivity have also been associated with mood disorder (29,30). Longitudinal examination of DMN connectivity in BC is required to investigate potential changes in connectivity direction over time.…”

Section: Discussionmentioning

confidence: 99%

Default mode network connectivity distinguishes chemotherapy-treated breast cancer survivors from controls

Kesler

Wefel²,

Hosseini

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

103

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Breast cancer (BC) chemotherapy is associated with cognitive changes including persistent deficits in some individuals. We tested the accuracy of default mode network (DMN) resting state functional connectivity patterns in discriminating chemotherapy treated (C+) from non–chemotherapy (C−) treated BC survivors and healthy controls (HC). We also examined the relationship between DMN connectivity patterns and cognitive function. Multivariate pattern analysis was used to classify 30 C+, 27 C−, and 24 HC, which showed significant accuracy for discriminating C+ from C− (91.23%, P < 0.0001) and C+ from HC (90.74%, P < 0.0001). The C− group did not differ significantly from HC (47.06%, P = 0.60). Lower subjective memory function was correlated ( P < 0.002) with greater hyperplane distance (distance from the linear decision function that optimally separates the groups). Disrupted DMN connectivity may help explain long-term cognitive difficulties following BC chemotherapy.

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“…In the current study, increased functional connectivity between the interhemispheric prefrontal nodes of MDD patients was observed after BMRMI, a finding which may suggest that BMRMI could modulate cognitive reappraisal through regulating functional interactions in the prefrontal cortex. A recent study demonstrated that MDD patients showed lower voxel-mirrored homotopic connectivity (VMHC) in the medial prefrontal cortex (MPFC) than healthy subjects (Guo et al, 2013). Decreased connectivity in the frontal regions has been related to cognitive deficits in depression, and successful treatments appear to normalize these relationships (Beall et al, 2012).…”

Section: Specific Effect Of Bmrmi On Mddsmentioning

confidence: 99%

The effect of body–mind relaxation meditation induction on major depressive disorder: A resting-state fMRI study

Chen

Fang

et al. 2015

Journal of Affective Disorders

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, The effect of body-mind relaxation meditation induction on major depressive disorder: A resting-state FMRI study, Journal of Affective Disorders, http://dx.doi. org/10.1016/j.jad. 2015.04.030 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractBackground: Meditation has been increasingly evaluated as an important complementary therapeutic tool for the treatment of depression. The present study employed resting-state functional magnetic resonance imaging (rs-fMRI) to examine the effect of body-mind relaxation meditation induction (BMRMI) on the brain activity of depressed patients and to investigate possible mechanisms of action for this complex intervention.Method: 21 major depressive disorder patients (MDDs) and 24 age and gender-matched healthy controls (HCs) received rs-fMRI scans at baseline and after listening to a selection of audio designed to induce body-mind relaxation 2 meditation. The rs-fMRI data were analyzed using Matlab toolbox to obtain the amplitude of low-frequency fluctuations (ALFF) of the BOLD signal for the whole brain. A mixed-design repeated measures analysis of variance (ANOVA) was performed on the whole brain to find which brain regions were affected by the BMRMI. An additional functional connectivity analysis was used to identify any atypical connection patterns after the BMRMI.Results: After the BMRMI experience, both the MDDs and HCs showed decreased ALFF values in the bilateral frontal pole (BA10). Additionally, increased functional connectivity from the right dorsal medial prefrontal cortex (dmPFC) to the left dorsal lateral prefrontal cortex (dlPFC) and the left lateral orbitofrontal cortex (OFC) was identified only in the MDDs after the BMRMI.Limitation: In order to exclude the impact of other events on the participants' brain activity, the Hamilton Rating Scales for Depression (HDRS) were not measured after the body-mind relaxation induction. Conclusion:Our findings support the hypothesis that body-mind relaxation meditation induction may regulate the activities of the prefrontal cortex and thus may have the potential to help patients construct reappraisal strategies that can modulate the brain activity in multiple emotion-processing systems.

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Decreased interhemispheric resting-state functional connectivity in first-episode, drug-naive major depressive disorder

Cited by 126 publications

References 48 publications

Reduced Interhemispheric Resting-State Functional Homotopy in Obsessive-Compulsive Disorder

Reduced Interhemispheric Resting-State Functional Homotopy in Obsessive-Compulsive Disorder

Default mode network connectivity distinguishes chemotherapy-treated breast cancer survivors from controls

The effect of body–mind relaxation meditation induction on major depressive disorder: A resting-state fMRI study

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