Decreased Insulin Binding to Erythrocytes in Subjects With Turner's Syndrome

Breyer, Darja; Dumić, Miroslav; Cvitković, Petar; Pedersen, Oluf; Ročić, Boris

doi:10.1111/j.1651-2227.1983.tb09841.x

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…The mean insulin profile shows that the immediate insulin response and the mean secretory peak are significantly lower and therefore the insulin response to glucose oral load appears not only delayed but also flattened. Although the significant reduction in the insulin response to the OGTT and the reduction of the insulinogenic index do not allow us to rule out a rise in peripheral resistance to insulin, as recently reported [1], they are evidence of an impaired beta-cellular response to an oral glucose stimulus. As reported elsewhere [20], our patients also had a reduction in rapid insulin secretion.…”

Section: Discussionmentioning

confidence: 82%

Differences in carbohydrate tolerance in Turner syndrome depending on age and karyotype

et al. 1988

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Carbohydrate homeostasis was evaluated in 47 girls with Turner syndrome and in 25 "short normal" girls by means of an oral glucose tolerance test. Of the Turner patients 34% showed an impaired glucose tolerance vs 8% of the controls (chi 2 = 5.9, P less than 0.05). Mean glucose levels were significantly higher and mean insulin levels and insulinogenic index significantly lower in young Turner patients aged 5-12 years but not in adolescents aged 12-16 years. In both groups of patients, insulin levels and the insulinogenic index were significantly lower than those of the controls. In Turner patients between 12 and 16 years, carbohydrate tolerance improved and this may be explained by the lack of oestrogen release in these patients. Glucose tolerance was normal in patients with mosaicism. We conclude that (1) carbohydrate tolerance is defective in young children with Turner syndrome but improves in puberty due to the almost complete absence of oestrogen-progestogen secretion; (2) a difference in carbohydrate tolerance is evident depending on karyotype.

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Section: Discussionmentioning

confidence: 82%

Differences in carbohydrate tolerance in Turner syndrome depending on age and karyotype

et al. 1988

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“…7-9], Recently Caprio et al [10] demonstrated that insulin resistance is an early metabolic defect in subjects with Turner syn drome. Breycr et al [11] found a significantly decreased insulin binding to erythrocyte membrane receptors in Turner patients, and Stoppoloni et al [12] suggested an insulin receptor defect as the cause of insulin resistance in UTS.…”

Section: Introductionmentioning

confidence: 99%

Glucose Metabolism in Ullrich Turner Syndrome: Long-Term Effects of Therapy with Human Growth Hormone

et al. 1993

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The effects of GH therapy on glucose metabolism in 72 Turner patients treated with human GH (HGH) 2, 3 or 4 IU/m²/day for 2 years are reported. OGTTs were performed at 0, 3, 12 and 24 months. The overall frequency of glucose intolerance was 9.7% before therapy and did not change under HGH. No change in HbAlc and fasting glucose values occurred. Integrated blood sugar values in the OGTT (area under the curre) did not change with 2 and 3 IU but were significantly elevated over control after 2 years with 4IU. Insulin secretion was not significantly affected over time with 2 IU, whereas 3 and 4 IU produced significant increases which persisted after 2 years. Results indicate that glucose homeostasis is maintained under GH therapy at the expense of a compensatory increase in insulin secretion which persists at higher GH dosages.

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Insulin Resistance in a Patient with Diabetes Mellitus Associated with Turner's Syndrome.

et al. 1994

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Weevaluated insulin resistance and assessed the effect of gliclazide on insulin resistance in a patient with diabetes mellitus associated with Turner's syndrome. Insulin-induced glucose metabolism markedly decreased compared with 12 healthy subjects. The insulin dose-response curve of this patient shifted to the right and down, and recovered somewhat after the administration of gliclazide. This patient had exhibited marked insulin resistance, which seemed to be caused by a defect at the receptor and/or post-receptor levels. Gliclazide reduced her insulin resistance, which suggests that this agent is suitable for treating the insulin resistance in diabetic patients with Turner's syndrome. (Internal Medicine 33: 560-563, 1994)

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Decreased Insulin Binding to Erythrocytes in Subjects With Turner's Syndrome

Cited by 3 publications

References 5 publications

Differences in carbohydrate tolerance in Turner syndrome depending on age and karyotype

Differences in carbohydrate tolerance in Turner syndrome depending on age and karyotype

Glucose Metabolism in Ullrich Turner Syndrome: Long-Term Effects of Therapy with Human Growth Hormone

Insulin Resistance in a Patient with Diabetes Mellitus Associated with Turner's Syndrome.

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