Decreased IgM, IgA, and IgG response to pneumococcal vaccine in children with transient hypogammaglobulinemia of infancy

Abstract

In this study, although preliminary for the cohort size and the potential bias of age and vaccination schedule, we demonstrated that children with THI showed an abnormal anti-PCP response. Consistent with our previous report, a further tile is added to B-cell memory defect and immunoglobulin defec

Concentrations of Pneumococcal IgA and IgM are compromised in some individuals with antibody deficiencies

“…The IgA and IgM responses to pneumococcal vaccination may differentiate between transient and permanent immunodeficiencies [6] and has been shown to correlate to the number of individuals with a history of infection in CVID patients receiving IVIG. [7] In this study, we have extended the utility of the observation in Cavaliere [7] to more than CVID patients with the inclusion of HYPO, IgAD, and IgGD Table 4.…”

“…[2] Currently, the response to pneumococcal vaccination is assessed by measurement of IgG immunoglobulin only and is compromised in a number of antibody deficiencies. [3][4][5] The IgA and IgM responses to pneumococcal vaccination have been reported to be compromised in some pediatric patients with antibody deficiencies [6] and correlates with common variable immunodeficiency (CVID) patients and their history of infection. [7] Using reported unknown vaccination reference ranges [8] we measured the concentrations of Pneumococcal IgA and IgM responses to Pneumovax in individuals diagnosed with antibody deficiencies who had normal and abnormal pneumococcal capsular polysaccharide (PCP) IgG concentrations.…”

B lymphocyte subsets and outcomes in patients with an initial diagnosis of transient hypogammaglobulinemia of infancy

“…Six years later, we re‐evaluated the patients’ clinical findings and IgG levels. Patients whose IgG levels had normalized before they reached 4 years of age were diagnosed with definitive THI …”

“…Definitive THI diagnosis can only be made retrospectively in an infant who has been admitted to a clinic with recurrent infections and hypogammaglobulinemia after excluding the clinical and laboratory features of well‐defined immune‐deficiencies. Currently, it is impossible to predict which infant or child will recover from hypogammaglobulinemia and which will suffer from a more severe disease such as common variable immunodeficiency (CVID) …”

Clinical Associations of Biallelic and MonoallelicTNFRSF13BVariants in Italian Primary Antibody Deficiency Syndromes

“…IgM and IgA antibodies to 23 PS serotypes were quantified using a new ELISA test PS23 IgA and PS23 IgM ELISA, modified from the commercially available PS23 Pneumococcal Capsular Polysaccharide IgG VaccZyme ™ ELISA, as described in our previous papers [ 32 , 33 ].…”