Decreased human leukocyte antigen A*02:01 frequency is associated with risk of glioma and existence of human cytomegalovirus: a case–control study in Northern China

Han, Sheng; Deng, Junming; Wang, Zixun; Liu, Huan; Cheng, Wen; Wu, Anhua

doi:10.1007/s00262-017-2018-7

Cited by 11 publications

(17 citation statements)

References 42 publications

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“…In our previous study we detected IE1–72 immunoreactivity in 76.1% of malignant glioma specimens of various grades, and pp65 in 65.7%; no IE1–72- or pp65-positive cells were detected in control brain tissue specimens [11], a finding consistent with the results of Cobbs et al [7] and Mitchell et al [12]. However, in other studies [18–22], no evidence of a direct association between malignancies and HCMV infection was found, and the association of HCMV with malignancies is still controversial, with conflicting reports in the literature [7–9, 16, 18–32]. Whether HCMV plays a role in the tumor progression, or whether tumor growth simply provides a supportive environment for local reactivation and propagation of the virus, is also generally unclear.…”

Section: Discussionsupporting

confidence: 80%

Is the presence of HCMV components in CNS tumors a glioma-specific phenomenon?

Ding

Zhao

Sun

et al. 2019

Virol J

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Background Human cytomegalovirus (HCMV) has been associated with malignant gliomas. The purpose of the present study was to investigate the presence of HCMV in common non-glial tumors of the central nervous system (CNS) and to determine whether it is a glioma-specific phenomenon. Methods Using HCMV-specific immunohistochemical staining, HCMV proteins IE1–72 and pp65 were examined in 65 meningiomas (benign, atypical and malignant), 45 pituitary adenomas, 20 cavernous hemangiomas, and 30 metastatic carcinomas specimens. HCMV DNA was also measured in these tumor tissues and the peripheral blood from patients using nested PCR. Results In meningioma, IE1–72 was detected in 3.1% (2/65) and pp65 was detected in 4.6% (3/65), whereas no IE1–72 and pp65 were detected in atypical and malignant meningioma. A low level of IE1–72 immunoreactivity 6.7% (2/30) was detected in metastatic carcinoma; pp65 was not detected. No HCMV components were detected in pituitary adenoma and cavernous hemangioma. The results of immunohistochemical staining were confirmed by HCMV-specific PCR. HCMV DNA was not detected in the peripheral blood of the non-glial CNS tumors patients. Conclusions Our results demonstrate that the presence of HCMV components is not an entirely glioma-specific phenomenon, and that HCMV is present in a low percentage in some non-glioma CNS tumors. Comparing HCMV-positive non-glial CNS tumors with HCMV-positive gliomas may cast light on the mechanism and role of HCMV in CNS tumors. Electronic supplementary material The online version of this article (10.1186/s12985-019-1198-5) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 80%

Is the presence of HCMV components in CNS tumors a glioma-specific phenomenon?

Ding

Zhao

Sun

et al. 2019

Virol J

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“…Antibodies to HCMV IE1 (68-72-kDa protein) were used on 773 tumor samples from 21 studies. Samples were positive for HCMV IE1 in 14 studies [2,4,26,27,29,36,38,46,50,56,57,63,87] and negative in 7 [44,67,69,76,82,85,96]. In 389 of 773 samples (50.3%), HCMV IE1 proteins were detected with antibody clones E13 [87], 6F8.2 [4], or 8B1.2 [4,26,46]; in 13 studies, the clones were not specified [2,27,29,36,38,50,56,57,63,67,69,82,85].…”

Section: Hcmv Ie Protein Detectionmentioning

confidence: 99%

Presence of the Human Cytomegalovirus in Glioblastomas—A Systematic Review

Peredo-Harvey

Rahbar

Söderberg‐Nauclér

2021

Cancers

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Glioblastoma is a malignant brain tumor with a dismal prognosis. The standard treatment has not changed in the past 15 years as clinical trials of new treatment protocols have failed. A high prevalence of the human cytomegalovirus (HCMV) in glioblastomas was first reported in 2002. The virus was found only in the tumor and not in the surrounding healthy brain tissue. Many groups have confirmed the presence of the HCMV in glioblastomas, but others could not. To resolve this discrepancy, we systematically reviewed 645 articles identified in different databases. Of these, 81 studies included results from 247 analyses of 9444 clinical samples (7024 tumor samples and 2420 blood samples) by different techniques, and 81 articles included 191 studies that identified the HCMV in 2529 tumor samples (36% of all tumor samples). HCMV proteins were often detected, whereas HCMV nucleic acids were not reliably detected by PCR methods. Optimized immunohistochemical techniques identified the virus in 1391 (84,2%) of 1653 samples. These data suggest that the HCMV is highly prevalent in glioblastomas and that optimized immunohistochemistry techniques are required to detect it.

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“…However, another recent study including Northern Chinese citizens showed decreased risk of glioma development in people with HLA-A*0201. Third, all but one study included only western populations (18). In this context, we sought to evaluate whether the polymorphism of HLA can affect the risk of GBM development in Koreans.…”

Section: Baseline Characteristics Of Gbm Patientsmentioning

confidence: 99%

“…A few studies have evaluated potential association between HLA polymorphism and risk of glioma; however, the results remain unclear (17)(18)(19)(20)(21)(22)(23)(24). Most studies used serologic methods, which resulted in only two-digit resolution of HLA genotypes (19)(20)(21)(22)(23).…”

Section: Introductionmentioning

confidence: 99%

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HLA Polymorphisms and Risk of Glioblastoma in Koreans

Ahn¹,

Choi²,

Baek³

et al. 2021

Preprint

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Purpose Immune responses for cancer cells can be altered according to genetic variation of human leukocyte antigen (HLA). Association of HLA polymorphism with risk of various cancer types is well known. However, the association between HLA and glioblastoma (GBM) remains uncertain. We sought to evaluate the association of HLA polymorphism with risk of GBM development in Koreans. Materials and Methods A case-control study was performed to identify the odds ratios (OR) of HLA class I and II genes for GBM. The control group consisted of 142 healthy Korean volunteers, and the GBM group was 80 patients with newly diagnosed GBM at our institution. HLA class I (-A, -B, and –C) and class II (-DR, -DQ, and –DP) genotyping was performed by high-resolution polymerase chain reaction (PCR)-sequence-based typing (PCR-SBT) methods. Results There were significantly decreased frequencies of HLA-A*26:02 (OR 0.22 CI 0.05-0.98), HLA-C*08:01 (OR 0.29 CI 0.10-0.87), and HLA-DRB1*08:03 (OR 0.32 CI 0.11-0.98), while there was significantly increased frequency of HLA-C*04:01 (OR 2.29 CI 1.05-4.97). In analysis of haplotypes, the frequency of DRB1*14:05-DQB1*05:03 was significantly decreased (OR 0.22 CI 0.05-0.98). Conclusion This study suggests that genetic variations of HLA may affect GBM development in Koreans. Further investigations with larger sample sizes are needed to delineate any potential role of the HLA polymorphisms in the pathogenesis of GBM development.

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Decreased human leukocyte antigen A*02:01 frequency is associated with risk of glioma and existence of human cytomegalovirus: a case–control study in Northern China

Abstract: There is a correlation between decreased HLA-A*0201 allele frequency and glioma susceptibility.

Cited by 11 publications

References 42 publications

Is the presence of HCMV components in CNS tumors a glioma-specific phenomenon?

Is the presence of HCMV components in CNS tumors a glioma-specific phenomenon?

Presence of the Human Cytomegalovirus in Glioblastomas—A Systematic Review

HLA Polymorphisms and Risk of Glioblastoma in Koreans

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