Abstract:Inhalation anesthesia with isoflurane is occasionally associated with the postoperative cognitive impairment and shift in the circadian rhythms. The microglial activation is suggested to be pathogenesis of these complications. Glucagonlike peptide 1 (GLP-1) is specifically expressed in microglia and are associated with circadian transcription factor in hippocampus. We previously reported that hippocampal GLP-1 is reduced with cognitive dysfunction. Therefore, we investigated whether the hippocampal GLP-1 is af… Show more
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