1979
DOI: 10.1172/jci109306
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Decreased Heat-Labile Opsonic Activity and Complement Levels Associated with Evidence of C3 Breakdown Products in Infected Pleural Effusions

Abstract: A B S T R A C T Heat-labile opsonic activity was measured simultaneously in serum and pleural fluid of patients with transudates, infectious exudates (with positive or negative bacterial culture) and neoplastic exudates, using two different complement-dependent phagocytic tests: the killing of Staphylococcus aureus Wood 46 variant strain (K50 opsonic titers) and the assessment of ingestion rate of endotoxin-coated paraffin particles (Oil Red 0 uptake test). K50 opsonic titers were lower in culture-positive ple… Show more

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Cited by 53 publications
(32 citation statements)
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“…None of these controls exhibited any bactericidal activity against the test strain. The lack of bacterial killing with heatinactivated serum as the opsonic source confirmed the previously defined opsonic requirements of S. aureus strain Wood 46 [13,24,26].…”
Section: Methodssupporting
confidence: 84%
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“…None of these controls exhibited any bactericidal activity against the test strain. The lack of bacterial killing with heatinactivated serum as the opsonic source confirmed the previously defined opsonic requirements of S. aureus strain Wood 46 [13,24,26].…”
Section: Methodssupporting
confidence: 84%
“…The same phagocytic bactericidal assay previously described by our laboratory [13,24], was used throughout the present study to measure opsonic activities of tissue cage fluid and serum, the opsonic coating of S. aureus in the animal model, and the overall killing by as well as the ingestion rate of PMNLs.…”
Section: Methodsmentioning
confidence: 99%
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