Decreased heart rate variability in patients with psoriatic arthritis

Abstract

The purpose of this study was to investigate autonomous regulation of the cardiac activity by means of the heart rate variability (HRV) assessment and possible influence of conventional cardiovascular risk factors and disease activity parameters on it in patients with psoriatic arthritis (PsA). In total, 38 patients with the reliable diagnosis of PsA without clinically manifest cardiovascular pathology, known rhythm or conduction disturbances, diabetes mellitus, and hypercholesterolemia were included. In the control group, 25 age- and sex-matched healthy persons comparable with PsA patients in cardiovascular risk profile were included. For the HRV analysis, we used 5-min-long ECG records obtained at rest. Time and frequency domain parameters of HRV were calculated. Patients with PsA had decreased HRV in comparison to healthy controls as reflected by decrease of the standard deviation of normal R-R intervals (65.1 ± 66.8 vs. 83.2 ± 43.3 ms, respectively, p = 0.011), of the percentage of normal R-R intervals that differ by more than 50 ms (12.9 ± 15.4 vs. 20.6 ± 17.1 %, respectively, p = 0.035), and of the total power (2,069.4 ± 1,537.8 vs. 2,942.5 ± 1,734.2 ms(2), respectively, p = 0.006). A significant correlation of HRV parameters with disease duration and parameters of disease activity in PsA was found. Patients with PsA had impaired autonomous regulation of the cardiac activity, which is likely to be related to the presence of systemic inflammation and which could contribute to the increase of cardiovascular risk in this disease.

7.7 the Effect of Marine N-3 Polyunsaturated Fatty Acids on Cardiac Autonomic and Hemodynamic Function in Patients With Psoriatic Arthritis: A Randomised, Double-Blind, Placebo-Controlled Trial

“…A few studies have investigated HRV in PsA and demonstrated attenuated HRV. In a study with 38 patients with PsA and 25 healthy controls using 5-min HRV Gaydukova et al [49] found that SDNN was 65.1 ms and pNN50 12.9% in the PsA patients whereas in healthy controls SDNN and pNN50 were higher (83.2 ms and 20.6%, respectively). Proietti et al [50] also used short-term HRV in 26 patients with psoriasis and 27 healthy controls and found a significant difference in RMSDD between patients with psoriasis (39.…”

Heart Rate Variability in Familial Mediterranean Fever Patients

“…Laversuch et al (21) showed that HRV negatively affected systemic lupus erythematosus patients by using spectral analyses. It has been shown that HRV is suppressed in Behcet's disease patients by Ozdemir et al (22) and in psoriatic arthritis patients by Gaydukova et al (23).…”

Psoriasis: An autoimmune disorder

“…It is associated with the inflammation of joints. In the general population it occurs in approximately 0.1 to 0.25 % 27,28,29 . PsA is more severe than rheumatoid arthritis (RA) but the prognosis is similar 30 .…”