Decreased gray matter volume is associated with the subtypes of psychotic symptoms in patients with antipsychotic-naïve mild or moderate Alzheimer's disease: A voxel-based morphometry study

Lee, Young-Min; Chung, Yeong Jin; Lee, Byung-Dae; Moon, Eunsoo; Jeong, Hee-Jeong; Kim, Ji-Hoon; Kim, Hak-Jin; Mun, Chi-Woong; Kim, Tae-Hyung; Kim, Young-Hoon; Kim, Eun-Joo

doi:10.1016/j.pscychresns.2015.12.002

Cited by 14 publications

(14 citation statements)

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“…Anticipating differences in mechanisms of hallucinations between psychiatric illnesses and neurodegenerative diseases based on distinctions in phenomenology, modality, prevalence [51], and the significant participant age separation among primary studies (t(25) = 17.324, p < 0.001), we performed a meta-analysis including schizophrenia, first episode schizophrenia (FES), first episode psychosis (FEP), and young adults at clinical risk for psychosis (at-risk mental state long-term, ARMS-LT), and BD, and a second of neurodegenerative disorders, including PD and AD. Of the 16 studies included in these two cross-sectional meta-analyses, three (see Table 1) did not make an explicit comparison between a hallucination (H) and no-hallucinations (NH) group, though the majority of patients in each group respectively either did or did not have hallucinations, and were therefore included [52], [53], [54]. A jackknife sensitivity analysis was performed on the meta-analyses to test reproducibility of significant brain regions by iteratively repeating the statistical analysis systematically excluding one study [55].…”

Section: Methodsmentioning

confidence: 99%

Meta-analytic Evidence for the Plurality of Mechanisms in Transdiagnostic Structural MRI Studies of Hallucination Status

et al. 2019

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Background Hallucinations are transmodal and transdiagnostic phenomena, occurring across sensory modalities and presenting in psychiatric, neurodegenerative, neurological, and non-clinical populations. Despite their cross-category occurrence, little empirical work has directly compared between-group neural correlates of hallucinations. Methods We performed whole-brain voxelwise meta-analyses of hallucination status across diagnoses using anisotropic effect-size seed-based d mapping (AES-SDM), and conducted a comprehensive systematic review in PubMed and Web of Science until May 2018 on other structural correlates of hallucinations, including cortical thickness and gyrification. Findings 3214 abstracts were identified. Patients with psychiatric disorders and hallucinations (eight studies) exhibited reduced gray matter (GM) in the left insula, right inferior frontal gyrus, left anterior cingulate/paracingulate gyrus, left middle temporal gyrus, and increased in the bilateral fusiform gyrus, while patients with neurodegenerative disorders with hallucinations (eight studies) showed GM decreases in the left lingual gyrus, right supramarginal gyrus/parietal operculum, left parahippocampal gyrus, left fusiform gyrus, right thalamus, and right lateral occipital gyrus. Group differences between psychiatric and neurodegenerative hallucination meta-analyses were formally confirmed using Monte Carlo randomizations to determine statistical significance, and a jackknife sensitivity analysis established the reproducibility of results across nearly all study combinations. For other structural measures (28 studies), the most consistent findings associated with hallucination status were reduced cortical thickness in temporal gyri in schizophrenia and altered hippocampal volume in Parkinson's disease and dementia. Additionally, increased severity of hallucinations in schizophrenia correlated with GM reductions within the left superior temporal gyrus, right middle temporal gyrus, bilateral supramarginal and angular gyri. Interpretation Distinct patterns of neuroanatomical alteration characterize hallucination status in patients with psychiatric and neurodegenerative diseases, suggesting a plurality of anatomical signatures. This approach has implications for treatment, theoretical frameworks, and generates refutable predictions for hallucinations in other diseases and their occurrence within the general population. Funding None.

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Section: Methodsmentioning

confidence: 99%

Meta-analytic Evidence for the Plurality of Mechanisms in Transdiagnostic Structural MRI Studies of Hallucination Status

et al. 2019

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“…None of the criteria discussed above make reference to disease-specific or psychosis-specific biomarkers. However, several studies have found abnormalities of neuroimaging biomarkers for dementia-related psychosis, including reduced gray matter volume on T1 weighted structural magnetic resonance imaging (MRI) [68][69][70][71], decreased cerebral blood flow on single photon emission computed tomography (SPECT) [72][73][74], and decreased metabolism on FDG-PET [75]. Several qualitative reviews have summarized these findings, noting significant heterogeneity, although in general findings have implicated the right frontal cortex [76][77][78].…”

Section: Imaging Markersmentioning

confidence: 99%

Revisiting Criteria for Psychosis in Alzheimer’s Disease and Related Dementias: Toward Better Phenotypic Classification and Biomarker Research

Fischer

Ismail

Youakim

et al. 2020

JAD

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Background: Psychotic symptoms are common in Alzheimer's disease (AD) and related neurodegenerative disorders and are associated with more rapid disease progression and increased mortality. It is unclear to what degree existing criteria are utilized in clinical research and practice. Objective: To establish research criteria for the diagnosis of psychosis in AD. Methods: The International Society to Advance Alzheimer's Research and Treatment (ISTAART) Neuropsychiatric Symptoms (NPS) Professional Interest Area (PIA) psychosis subgroup reviewed existing criteria for psychosis in AD and related dementias. Through a series of in person and on-line meetings, a priority checklist was devised to capture features necessary for current research and clinical needs. PubMed, Medline and other relevant databases were searched for relevant criteria. Results: Consensus identified three sets of criteria suitable for review including those of Jeste and Finkel, Lyketsos, and the Diagnostic and Statistical Manual for Mental Disorders, 5th edition. It was concluded that existing criteria could be augmented by including a more specific differentiation between delusions and hallucinations, address overlap with related conditions (agitation in particular), adding the possibility of symptoms emerging in the preclinical and prodromal phases, and building on developing research in disease biomarkers. Conclusion: We propose criteria, developed to improve phenotypic classification of psychosis in AD, and advance the research agenda in the field to improve epidemiological, biomarker, and genetics research in the field. These criteria serve as a complement to the International Psychogeriatric Association criteria for psychosis in neurocognitive disorders.

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“…Cross‐sectional studies that have investigated structural and functional changes in AD psychotic patients found alterations in a number of regions, including the frontal, temporal, parietal, and occipital cortices, mainly in the right hemisphere. Neuroimaging studies that have focused on distinct psychotic subtypes found that the misidentification subtype is associated with greater atrophy in the ventral visual stream and the left parahippocampal regions as well as in the right middle frontal gyrus, the middle temporal gyrus, the inferior parietal lobule, and the occipital lobe, whereas the paranoid subtype is not associated with a greater degree of atrophy than that observed in non‐psychotic patients . When Nakaaki et al (2013) compared patients who developed delusions over time with those who did not, they detected greater grey matter atrophy in the bilateral parahippocampal gyri, the right posterior cingulate gyrus, and the right insula in patients who developed delusions .…”

Section: Introductionmentioning

confidence: 99%

Psychosis of Alzheimer's disease: Neuropsychological and neuroimaging longitudinal study

D'Antonio

Vita

Zazzaro

et al. 2019

Int J Geriat Psychiatry

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Objectives Psychosis of Alzheimer's disease (AD) may represent a distinct disease phenotype; however, neuropsychological profile and neural basis linked to this phenotype have not yet been clarified. In this study, we aimed at detecting whether impairment in specific cognitive domains predicts the onset of psychosis in AD patients and what grey matter alterations, their location, and the rate of atrophy are associated with psychosis of AD. Methods Longitudinal neuropsychological data from AD patients with and without psychosis were analysed to determine whether the neuropsychological profile can predict the onset of psychosis. A voxel‐based morphometry (VBM) on longitudinal T1‐weighted images was used to explore differences in grey matter volume and in the rate of atrophy between groups. Results Noncognitive domain predicted the psychosis onset. However, AD patients with psychosis exhibited greater atrophy in the right anterior‐inferior temporal lobe, including the fusiform gyrus (cluster‐p‐family‐wise error [pfwe] < 0.05; peak‐p uncorrected [pUNC] < 0.001) as well as greater rate of atrophy in the right insula than nonpsychotic patients (cluster‐pFWE = 0.075; peak‐pUNC < 0.001). The anterior‐inferior temporal lobe is part of the ventral visual stream, and the insula plays a key role in the salience network. Conclusions This finding suggests that damage in these areas underpins an impairment in the visual processing of the objects and an impairment in the attribution of salience to the misperceived stimuli, which in turn leads to the onset of psychosis. These findings tie in well with the neuropsychological model of psychosis, according to which the simultaneous presence of two factors, namely misperception and misattribution, underlies psychosis in dementia.

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Decreased gray matter volume is associated with the subtypes of psychotic symptoms in patients with antipsychotic-naïve mild or moderate Alzheimer's disease: A voxel-based morphometry study

Cited by 14 publications

References 41 publications

Meta-analytic Evidence for the Plurality of Mechanisms in Transdiagnostic Structural MRI Studies of Hallucination Status

Meta-analytic Evidence for the Plurality of Mechanisms in Transdiagnostic Structural MRI Studies of Hallucination Status

Revisiting Criteria for Psychosis in Alzheimer’s Disease and Related Dementias: Toward Better Phenotypic Classification and Biomarker Research

Psychosis of Alzheimer's disease: Neuropsychological and neuroimaging longitudinal study

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