Decreased gray matter volume in the left hippocampus and bilateral calcarine cortex in coal mine flood disaster survivors with recent onset PTSD

Zhang, Jian; Tan, Qingrong; Yin, Hong; Zhang, Xiaoliang; Yi, Huan; Tang, Lihua; Wang, Huaihai; Xu, Junqiang; Li, Lingjiang

doi:10.1016/j.pscychresns.2010.09.001

Cited by 90 publications

(75 citation statements)

References 54 publications

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“…Several studies found inversely correlations between hippocampal volume and the measures of symptom severity [38], [44], [48]–[51]. However, other studies had also shown no associations between bilateral hippocampal volume and the CAPS scores [7], [9], [15], [18].…”

Section: Discussionmentioning

confidence: 99%

“…However, only one research group had reported the hippocampal structural alteration in coal mining disaster-related PTSD. They found that coal mine floods-related PTSD subjects had significantly reduced fractional anisotropy value in bilateral hippocampal body [37], and decreased volume and density in the left anterior hippocampus compared with survivors without PTSD [38]. The victims of the coal mine disaster had high homogeneity in demographic background, trauma intensity, and duration of trauma exposure, which offers an advantage in evaluating the PTSD-related structural brain damage.…”

Section: Introductionmentioning

confidence: 99%

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Structural Impairments of Hippocampus in Coal Mine Gas Explosion-Related Posttraumatic Stress Disorder

Zhang

Zhuo

et al. 2014

PLoS ONE

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Investigations on hippocampal and amygdalar volume have revealed inconsistent results in patients with posttraumatic stress disorder (PTSD). Little is known about the structural covariance alterations between the hippocampus and amygdala in PTSD. In this study, we evaluated the alteration in the hippocampal and amygdalar volume and their structural covariance in the coal mine gas explosion related PTSD. High resolution T1-weighted magnetic resonance imaging (MRI) was performed on coal mine gas explosion related PTSD male patients (n = 14) and non-traumatized coalminers without PTSD (n = 25). The voxel-based morphometry (VBM) method was used to test the inter-group differences in hippocampal and amygdalar volume as well as the inter-group differences in structural covariance between the ipsilateral hippocampus and amygdala. PTSD patients exhibited decreased gray matter volume (GMV) in the bilateral hippocampi compared to controls (p<0.05, FDR corrected). GMV covariances between the ipsilateral hippocampus and amygdala were significantly reduced in PTSD patients compared with controls (p<0.05, FDR corrected). The coalminers with gas explosion related PTSD had decreased hippocampal volume and structural covariance with the ipsilateral amygdala, suggesting that the structural impairment of the hippocampus may implicate in the pathophysiology of PTSD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Structural Impairments of Hippocampus in Coal Mine Gas Explosion-Related Posttraumatic Stress Disorder

Zhang

Zhuo

et al. 2014

PLoS ONE

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“…The study by Hendler et al [7] on male veterans with PTSD found that the lateral occipital complex (LOC), a brain region critical for object perception, had no reduction in activity as a result of repeated presentations of trauma-related stimuli indicating diminished habituation in PTSD patients. In addition to functional studies, there are a small number of reports suggesting reduced gray matter volume in the occipital lobe in PTSD patients [32][33][34], however these findings are yet to be validated.…”

Section: Introductionmentioning

confidence: 99%

Altered spontaneous neuronal activity of visual cortex and medial anterior cingulate cortex in treatment-naïve posttraumatic stress disorder

Zhu¹,

Zhang²,

Zhan³

et al. 2014

Comprehensive Psychiatry

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“…Our findings support the hypothesis that the psychiatric symptoms induced psychological stress, subsequently induced the GMV reduction in some key brain regions, such as sgACC. [40,41].…”

Section: Discussionmentioning

confidence: 99%

“…Some other previous studies have also reported this counterintuitive phenomenon. Previous studies have proposed that the severity of structural or functional alterations does not correlate with the severity of clinical symptoms, possibly indicating that the structural or functional alterations should only be used as a quality index to assist in the disease diagnosis and not as a quantity index to assess the severity of the disease [41][42][43][44].…”

Section: Discussionmentioning

confidence: 99%

Depressive symptom in the first-episode schizophrenic patients is related to the reduction of grey matter volume in the subgenual anterior cingulate cortex - a pilot study

Xu¹,

He²,

Chen³

et al. 2018

Oncotarget

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Approximately 25-75% of patients with schizophrenia also present major depressive systems. Investigations into the pathological features associated with depressive symptoms in patients with schizophrenia would provide important information for the development of treatments for depressive symptoms in patients with schizophrenia. In present study, we enrolled 17 first-episode schizophrenic patients with depressive symptoms and 17 well-matched first-episode schizophrenic patients without depressive symptoms and compared differences in their grey mater volume (GMV) using voxel-based morphometry (VBM). We observed significantly decreased GMV in the subgenual anterior cingulate cortex (sgACC) in the first episode schizophrenic patients with depressive symptoms compared to the first episode schizophrenic patients without depressive symptoms. However, we did not observe a correlation between the severity of the decreased GMV and the severity of depressive symptoms. Although convincing evidence supporting this postulation is lacking and requires further study for confirmation, to some extent, our findings provide indirect evidence for the suggestion that the reduction of the GMV in the sgACC may play a key role in the depressive symptoms in the first episode schizophrenic patients.

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Decreased gray matter volume in the left hippocampus and bilateral calcarine cortex in coal mine flood disaster survivors with recent onset PTSD

Cited by 90 publications

References 54 publications

Structural Impairments of Hippocampus in Coal Mine Gas Explosion-Related Posttraumatic Stress Disorder

Structural Impairments of Hippocampus in Coal Mine Gas Explosion-Related Posttraumatic Stress Disorder

Altered spontaneous neuronal activity of visual cortex and medial anterior cingulate cortex in treatment-naïve posttraumatic stress disorder

Depressive symptom in the first-episode schizophrenic patients is related to the reduction of grey matter volume in the subgenual anterior cingulate cortex - a pilot study

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