Decreased gray matter volume and increased white matter volume in patients with neovascular age-related macular degeneration: a voxel-based morphometry study

Shen, Yidi; Ge, Qian‐Min; Pan, Yi‐Cong; Shu, Hui‐Ye; Zhang, Lijuan; Li, Qiuyu; Liang, Rong‐Bin; Shao, Yi; Yao, Yu

doi:10.18632/aging.203610

Cited by 3 publications

(2 citation statements)

References 39 publications

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“…25, 26 In addition, previous studies have found that both the volume of BG are found to decrease with age in healthy volunteers. 27, 28 In this study, we found that this phenomenon is not only in healthy people, but also in patients with high blood pressure. These findings are reasonable, and this may be because with the increase of age and the continuous rise of blood pressure, hypoxia caused by reduced blood flow and abnormal neurotransmitter transmission caused by continuous resistance led to obvious atrophy of the nerve nuclei in the basal ganglia.…”

Section: Discussionmentioning

confidence: 53%

Microenvironment changes in basal ganglia region correlates with hypertension at 7T MRI

Liang,

Meng,

et al. 2023

Preprint

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BACKGROUNDHypertension, a major risk factor for stroke, is associated with the changes of microenvironment in basal ganglia region, including microstructural characteristics and mapping relationship of blood flow and peripheral nerve tissue.MATERIALS AND METHODSThe morphological characteristics of the lenticulostriate arteries (LSA) and peripheral nerve nuclei were compared by 7T time-of-Flight MRA between 32 hypertensive patients (mean age: 47.1±9.6 years) and 48 age-matched healthy subjects (mean age: 47.7±8.1 years) from September 2022 to February 2023. The ITK-SNAP software was used to measure the morphological characteristics of the LSA and the volume of the nuclei.RESULTSThe average stems number and length of LSA was significantly higher in healthy people than those in hypertension patients (p<0.05). The volumes of the peripheral nerve nuclei in healthy subjects were significantly larger than those in hypertensive patients (p<0.05). There was a positive correlation between the volume of putamen and the length of LSA in the left hemisphere (r = 0.23, p < 0.05). The number of stems was found to be positively correlated with Globus pallidus volume (r = 0.27, p < 0.05) and internal capsule volume (r = 0.25, p < 0.05) in the right hemisphere. For older adults (>45 year old), the average stems number of LSA and the volume of nuclei were significantly different (P <0.05).CONCLUSIONThe microstructure of the basal ganglia has changed obviously in patients with hypertension compared to healthy individuals when observed by 7T MRA.NOVELTY AND RELEVANCEWhat Is New?Previously studies on basal ganglia of hypertension using 7T MRI mainly focused on the imaging of LSA, but have not identified significant associations between the LSA and peripheral nerve tissue. However, the occurrence of hypertension adverse events such as intracerebral hemorrhage is closely related to the microenvironment formed by the lenticular artery and peripheral nerve tissue. Once the potential correlation is taken into account, the treatment and follow-up plan related to hypertension may be changed to effectively reduce the adverse.What Is Relevant?The rupture of LSA is a recognized cause of stroke in the basal ganglia of hypertensive patients, and the change of the microenvironment of peripheral nerve tissue is closely related to the rupture of LSA. The current findings confirm this notion and identify a potential association between the LSA and peripheral nerve nuclei in hypertensive patients, reinforcing the causal relationship between changes in follow-up strategies for lifelong hypertension and disease risk.Clinical/Pathophysiological Implications?Consider early and active assessment of basal ganglia blood flow and peripheral nerve tissue changes in all hypertensive patients to help reduce the risk of adverse events (such as cerebral hemorrhage, cerebral infarction, cognitive impairment, etc.) in individuals.

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Section: Discussionmentioning

confidence: 53%

Microenvironment changes in basal ganglia region correlates with hypertension at 7T MRI

Liang,

Meng,

et al. 2023

Preprint

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“…VBM facilitates the identification of brain areas associated with specific disorders, advancing our understanding of the structural changes caused by those diseases. Recently, the VBM approach has been successfully used in many ocular diseases, such as age-related macular degeneration ( Ge et al, 2021 ), blindness ( Pan et al, 2007 ), and primary angle-closure glaucoma ( Jiang et al, 2018 ). The technique has been successfully demonstrated to be reliable and credible in clarifying pathophysiological pathways and identifying aberrant anatomy in ophthalmological illnesses.…”

Section: Introductionmentioning

confidence: 99%

Altered whole-brain gray matter volume in form-deprivation myopia rats based on voxel-based morphometry: A pilot study

et al. 2023

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BackgroundMyopia is one of the major public health problems worldwide. However, the exact pathogenesis of myopia remains unclear. This study proposes using voxel-based morphometry (VBM) to investigate potential morphological alterations in gray matter volume (GMV) in form-deprivation myopia (FDM) rats.MethodsA total of 14 rats with FDM (FDM group) and 15 normal controls (NC group) underwent high-resolution magnetic resonance imaging (MRI). Original T2 brain images were analyzed using VBM method to identify group differences in GMV. Following MRI examination, all rats were perfused with formalin, and immunohistochemical analysis of NeuN and c-fos levels was performed on the visual cortex.ResultsIn the FDM group, compared to the NC group, significantly decreased GMVs were found in the left primary visual cortex, left secondary visual cortex, right subiculum, right cornu ammonis, right entorhinal cortex and bilateral molecular layer of the cerebellum. Additionally, significantly increased GMVs were found in the right dentate gyrus, parasubiculum, and olfactory bulb.ConclusionsOur study revealed a positive correlation between mGMV and the expression of c-fos and NeuN in the visual cortex, suggesting a molecular relationship between cortical activity and macroscopic measurement of visual cortex structural plasticity. These findings may help elucidate the potential neural pathogenesis of FDM and its relationship to changes in specific brain regions.

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Visual training after central retinal loss limits structural white matter degradation: an MRI study

Kozak,

Ninghetto,

Wieteska

et al. 2024

Behav Brain Funct

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Background Macular degeneration of the eye is a common cause of blindness and affects 8% of the worldwide human population. In adult cats with bilateral lesions of the central retina, we explored the possibility that motion perception training can limit the associated degradation of the visual system. We evaluated how visual training affects behavioral performance and white matter structure. Recently, we proposed (Kozak et al. in Transl Vis Sci Technol 10:9, 2021) a new motion-acuity test for low vision patients, enabling full visual field functional assessment through simultaneous perception of shape and motion. Here, we integrated this test as the last step of a 10-week motion-perception training. Results Cats were divided into three groups: retinal-lesioned only and two trained groups, retinal-lesioned trained and control trained. The behavioral data revealed that trained cats with retinal lesions were superior in motion tasks, even when the difficulty relied only on acuity. 7 T-MRI scanning was done before and after lesioning at 5 different timepoints, followed by Fixel-Based and Fractional Anisotropy Analysis. In cats with retinal lesions, training resulted in a more localized and reduced percentage decrease in Fixel-Based Analysis metrics in the dLGN, caudate nucleus and hippocampus compared to untrained cats. In motion-sensitive area V5/PMLS, the significant decreases in fiber density were equally strong in retinal-lesioned untrained and trained cats, up to 40% in both groups. The only cortical area with Fractional Anisotropy values not affected by central retinal loss was area V5/PMLS. In other visual ROIs, the Fractional Anisotropy values increased over time in the untrained retinal lesioned group, whereas they decreased in the retinal lesioned trained group and remained at a similar level as in trained controls. Conclusions Overall, our MRI results showed a stabilizing effect of motion training applied soon after central retinal loss induction on white matter structure. We propose that introducing early motion-acuity training for low vision patients, aimed at the intact and active retinal peripheries, may facilitate brain plasticity processes toward better vision.

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Decreased gray matter volume and increased white matter volume in patients with neovascular age-related macular degeneration: a voxel-based morphometry study

Cited by 3 publications

References 39 publications

Microenvironment changes in basal ganglia region correlates with hypertension at 7T MRI

Microenvironment changes in basal ganglia region correlates with hypertension at 7T MRI

Altered whole-brain gray matter volume in form-deprivation myopia rats based on voxel-based morphometry: A pilot study

Visual training after central retinal loss limits structural white matter degradation: an MRI study

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