Decreased graft versus host reaction after intrahepatic lymphoid tissue implantation

Eloy, R.; Vuitton, Dominique A.; Vaultier, J.‐P.; Pousse, A.; Grenier, J F

doi:10.1016/0008-8749(76)90052-6

Cited by 9 publications

(1 citation statement)

References 18 publications

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“…Because human diabetics are treated with xenogeneic insulin, and because the chick embryonic pancreas provides a relatively pure source ofendocrine tissue, the effectiveness of this xenogeneic embryonic tissue in experimental diabetes was investigated in this study. The splenic lobes of chick embryos were implanted directly into the hepatic parenchyma of the rat recipient because the liver may represent an immunologically privileged site (25)(26)(27) Metabolic and chemical analyses. The insulin content of the chicken pancreases was determined according to the tech-FIGURE 1 Splenic (S) and ventral (V) lobes of the pancreas in the chick embryo.…”

Section: Introductionmentioning

confidence: 99%

Chick embryo pancreatic transplants reverse experimental diabetes of rats.

Eloy¹,

Haffen²,

Kédinger³

et al. 1979

J. Clin. Invest.

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A B S T R A C T The effectiveness of xenogeneic embryonic tissue in the treatment of experimental diabetes has been investigated in rats. The splenic lobes (80) of 15-to 18d-old chick embryos, composed almost exclusively of endocrine tissue, were implanted directly into the hepatic parenchyma of the rat recipient. The biochemical and metabolic changes in the recipients suggest that embryonic transplants of 15-d-old chick pancreases were able to significantly improve, for a prolonged period of time (18 mo), the diabetic state of nonimmunosuppressed rats. None of the recipients of 18-d-old embryos splenic lobes exhibited a long-term improvement ofthe diabetic state after transplantation. The complete destruction of the pancreatic B cells of the recipients was asssessed by: (a) immunocytochemical investigations of the recipient's pancreas, (b) measurement of insulin in the liver and pancreas of the recipients and (c) in situ vascular perfusion of their pancreas submitted to high glucose challenge. The results suggest that pancreatic tissue of the 15-d-old embryos is immunologically immature lacking one or several lymphocyte subsets implicated in the afferent loop of "non-self" recognition.

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Section: Introductionmentioning

confidence: 99%