Decreased glucose utilization in the striatum and frontal lobe in probable striatonigral degeneration

Volder, Anne De; Francart, Julie; Laterre, C.; Dooms, Grégoire; Bol, Anne; Michel, Christian; Goffinet, André M.

doi:10.1002/ana.410260210

Cited by 114 publications

(45 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, we note the selective vulnerability of the posterior cingulate and precuneus in such conditions as carbon monoxide poisoning [i.e., acute hypoxia (34)], diffuse brain ischemia (35), and Alzheimer's disease (32). This vulnerability, in the case of hypoxia and ischemia, has been ascribed to the position of the posterior cingulate and precuneus in the border zone between two of the main arteries supplying blood to the brain.…”

Section: Discussionmentioning

confidence: 99%

A default mode of brain function

Raichle

MacLeod

Snyder

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

10,838

474

8,444

View full text Add to dashboard Cite

A baseline or control state is fundamental to the understanding of most complex systems. Defining a baseline state in the human brain, arguably our most complex system, poses a particular challenge. Many suspect that left unconstrained, its activity will vary unpredictably. Despite this prediction we identify a baseline state of the normal adult human brain in terms of the brain oxygen extraction fraction or OEF. The OEF is defined as the ratio of oxygen used by the brain to oxygen delivered by flowing blood and is remarkably uniform in the awake but resting state (e.g., lying quietly with eyes closed). Local deviations in the OEF represent the physiological basis of signals of changes in neuronal activity obtained with functional MRI during a wide variety of human behaviors. We used quantitative metabolic and circulatory measurements from positron-emission tomography to obtain the OEF regionally throughout the brain. Areas of activation were conspicuous by their absence. All significant deviations from the mean hemisphere OEF were increases, signifying deactivations, and resided almost exclusively in the visual system. Defining the baseline state of an area in this manner attaches meaning to a group of areas that consistently exhibit decreases from this baseline, during a wide variety of goal-directed behaviors monitored with positron-emission tomography and functional MRI. These decreases suggest the existence of an organized, baseline default mode of brain function that is suspended during specific goaldirected behaviors. F unctional brain imaging studies in normal human subjects with positron-emission tomography (PET) and functional MRI (fMRI) have consistently revealed expected task-induced increases in regional brain activity during goal-directed behaviors (for brief reviews see refs. 1 and 2). These changes are detected when comparisons are made between a task state, designed to place demands on the brain, and a control state, with a set of demands that are uniquely different from those of the task state.Researchers have also frequently encountered task-induced decreases in regional brain activity even when the control state consists of lying quietly with eyes closed or passively viewing a stimulus. Whereas cortical increases in activity have been shown to be task specific and, therefore, vary in location depending on task demands, many decreases ( Fig. 1) appear to be largely task independent, varying little in their location across a wide range of tasks (3). This consistency with which certain areas of the brain participate in these decreases made us wonder whether there might be an organized mode of brain function that is present as a baseline or default state and is suspended during specific goal-directed behaviors.The primary issue this paper will address is whether these unexplained decreases merely arise from unrecognized increases (i.e., activation in the jargon of functional brain imaging) present only in the ''control state.'' Thus, on this argument, any control state, no matter how carefully it...

show abstract

Section: Discussionmentioning

confidence: 99%

A default mode of brain function

Raichle

MacLeod

Snyder

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

10,838

474

8,444

View full text Add to dashboard Cite

show abstract

“…The method may therefore be of use to distinguish this disease from Pick's disease (24), Alzheimer's disease (25), Parkinson's disease (26), striatonigral degeneration (27), and progressive supranuclear palsy (23) where such asymmetries are not usually observed. However, a right-left metabolic asymmetry in the cerebral cortex was described in one study of progressive supranuclear palsy (28), and a unilateral temporoparietal hypometabolism has been reported in progressive temporoparietal syndromes (29,30), but the asymmetry was not observed in subcortical structures.…”

Section: Resultsmentioning

confidence: 99%

Corticobasal degeneration: Decreased and asymmetrical glucose consumption as studied with PET

et al. 1992

View full text Add to dashboard Cite

Cerebral energy metabolism was studied by positron emission tomography and [18F]fluorodeoxyglucose in five patients with clinical diagnoses of probable corticobasal degeneration. A reduction in glucose consumption was observed in most cortical and subcortical structures compared to age-matched controls. The reduction was greatest on the side of the brain contralateral to the most affected limbs, as shown by the significantly lower ratios of contralateral to homolateral metabolic rates, in the temporal and sensorimotor cortex of patients compared to controls. A distinct asymmetry between the two hemispheres could be observed in a patient who was examined twice in the course of his illness. Detection of this asymmetrical decrease in brain cortical and subcortical glucose metabolism may prove useful as additional evidence supporting clinical diagnoses of the disease.

show abstract

“…Brooks and co-workers [ [ 16,17) in PET studies may also show mean differences between the two groups.…”

mentioning

confidence: 92%

Differentiation of multiple system atrophy from idiopathic Parkinson's disease using proton magnetic resonance spectroscopy

Davie¹,

Wenning²,

Barker³

et al. 1995

Annals of Neurology

154

View full text Add to dashboard Cite

Proton magnetic resonance spectroscopy, localized to the lentiform nucleus, was carried out in 7 patients with the pure or predominantly striatonigral variant (SND) of multiple system atrophy (MSA), 5 patients with the olivopontocerebellar variant of MSA, 9 patients with a clinical diagnosis of idiopathic Parkinson's disease (IPD), and 9 healthy age-matched controls. The MSA group with predominantly striatonigral involvement showed a significant reduction in the N-acetylaspartate (NAA)/creatine ratio (median, 1.19; range, 0.96-2.0; p < 0.02) compared with the NAA/creatine ratio from the control group (median, 1.76; range, 1.61-2.0). In contrast, the IPD group had a normal NAA/creatine ratio (median, 1.82; range, 1.19-2.31; p > 0.05). The NAA/creatine ratio was markedly reduced in 6 of the SND patients and in only 1 IPD patient. The choline/creatine ratio was also significantly lower in the SND group (median, 1.02; range, 0.91-1.23; p < 0.04) compared with the control group (median, 1.22; range, 1.05-1.65). The IPD group showed a normal lentiform choline/creatine ratio (median, 1.13; range, 0.89-1.65; p = 0.25) compared with controls. The olivopontocerebellar group also showed a significant reduction in the NAA/creatine ratio from the lentiform nucleus (median, 1.47; range, 1.22-1.68; p < 0.01) compared with the controls as well as a nonsignificant reduction in the choline/creatine ratio (median, 0.93; range, 0.85-1.27; p < 0.4).(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

Decreased glucose utilization in the striatum and frontal lobe in probable striatonigral degeneration

Cited by 114 publications

References 27 publications

A default mode of brain function

A default mode of brain function

Corticobasal degeneration: Decreased and asymmetrical glucose consumption as studied with PET

Differentiation of multiple system atrophy from idiopathic Parkinson's disease using proton magnetic resonance spectroscopy

Contact Info

Product

Resources

About