Decreased Global Interest in Oral Cancer During the COVID-19 Pandemic

Dalanon, Junhel; Matsuka, Yoshizo

doi:10.31557/apjcp.2021.22.7.2117

Cited by 5 publications

(3 citation statements)

References 29 publications

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“…Thus, dental specialists should be more involved in screening programs, and their further involvement in designing support and rehabilitation regimens for the post-COVID era is crucial. According to the study by Dalanon and Matsuka, COVID-19 decreased interest regarding oral and oropharyngeal cancers on a global scale, especially in middle and low-income countries (35).…”

Section: Discussionmentioning

confidence: 99%

Trends in the Incidence of Oral and Oropharyngeal Cancer in Southwest Iran from 2014 to 2019

Rahmanian Koushkaki,

Jahangirnezhad,

Cheraghi

2023

Jundishapur J Chronic Dis Care

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Background: Oral and oropharyngeal cancer is known as one of the few lethal oral diseases with a great burden associated with a high cost of treatment and rehabilitation, life-long impairments, and a nearly 50% mortality rate; therefore, it should be considered an increasingly severe health and social problem in the world due to its increased incidence. This makes the burden of oral and oropharyngeal cancer very high, with a hefty economic burden. Objectives: The current study was designed and conducted to investigate epidemiological features of oral and oropharyngeal cancer in the Khuzestan province of Iran. Methods: This cross-sectional study was conducted with raw data on cancer incidence obtained from the Khuzestan cancer registry as a subsequent of the Iranian population-based national cancer registry from 2014 to 2019. Recorded cases were standardized by ICD-10 and ICD-O-3 classifications and categorized by gender, age group, diagnosis, etc. The method of diagnosis in this study consisted of four categories. Descriptive data for the frequency and rate of each variable and analyses of associations between variables were conducted using the chi-squared test with a statistical significance of P < 0.05. Results: A total of 941 valid cases were identified in the study period, with a composition of males 675 cases and females 266 cases in total. More than 85% of reported cases were submitted to a database with pathologic reports, verifying a high data validity level. The crude rate in female cases had an upward trend in contrast to the crude rate in males, which shows a downward trend. Squamous cell carcinoma was the most diagnosed malignancy, with 532 cases (55%). Conclusions: The data on oral and oropharyngeal cancer in Khuzestan suggest that the overall incidence of the disease increased, particularly in females and younger age groups in the study period. Concerning increasing trends and the presence of most oral and oropharyngeal cancer cases in the active and young members of society of Khuzestan province of Iran, an extensive program for screening, prevention, and rehabilitation should be prioritized.

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Section: Discussionmentioning

confidence: 99%

Trends in the Incidence of Oral and Oropharyngeal Cancer in Southwest Iran from 2014 to 2019

Rahmanian Koushkaki,

Jahangirnezhad,

Cheraghi

2023

Jundishapur J Chronic Dis Care

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“…Owing to the ongoing global COVID-19 pandemic, interest in cancer detection has decreased [ 17 ]. However, saliva-based tests, such as PCR [ 18 ] and antigen-based tests [ 19 ], have become popular.…”

Section: Introductionmentioning

confidence: 99%

Salivary Metabolomics for Oral Cancer Detection: A Narrative Review

Panneerselvam¹,

Ishikawa

Krishnan

et al. 2022

Metabolites

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The development of low- or non-invasive screening tests for cancer is crucial for early detection. Saliva is an ideal biofluid containing informative components for monitoring oral and systemic diseases. Metabolomics has frequently been used to identify and quantify numerous metabolites in saliva samples, serving as novel biomarkers associated with various conditions, including cancers. This review summarizes the recent applications of salivary metabolomics in biomarker discovery in oral cancers. We discussed the prevalence, epidemiologic characteristics, and risk factors of oral cancers, as well as the currently available screening programs, in India and Japan. These data imply that the development of biomarkers by itself is inadequate in cancer detection. The use of current diagnostic methods and new technologies is necessary for efficient salivary metabolomics analysis. We also discuss the gap between biomarker discovery and nationwide screening for the early detection of oral cancer and its prevention.

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“…Oral squamous cell carcinoma (OSCC) is the most common histological type of cancer in the oral cavity, accounting for approximately 90% of oral cancer which is ranked the 15th leading cause of mortality and 16th most common malignancy worldwide (1,2). Unfortunately, the estimated incidence of cases and the anticipated deaths attributable to OSCC in 2018 in America are 33,950 and 6,800 respectively (3).…”

Section: Introductionmentioning

confidence: 99%

Overexpression of Mena is associated with tumor progression and poor prognosis in oral squamous cell carcinoma via EMT

Cui

Guo

et al. 2022

Front. Oncol.

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BackgroundMena, a cytoskeletal regulatory protein, is involved in actin-based regulation of cell motility and adhesion, and contributes to tumor invasion and metastasis. However, the role of Mena in oral squamous cell carcinoma remains unclear. This is the first research focusing on the prognostic value of Mena in OSCC. In this study, we aimed to investigate the correlation between Mena expression and clinicopathological significance, as well as prognostic value in OSCC.MethodsMena gene expression profiles of OSCC and normal tissues were collected from Oncomine, TCGA, and GEO databases. Biological function was analyzed through GO, KEGG and GSEA enrichment. Further, the expression level of Mena and tumor-related markers in 151 OSCC specimens was examined by IHC staining based on tissue microarray. Kaplan-Meier analysis was used to assess the prognostic performance of Mena in OSCC.ResultMena was generally upregulation in various malignancies, especially OSCC. The functional analyses indicated that Mena was involved in the assembly and regulation of actin, cell movement, and EMT. IHC staining revealed that high expression of Mena in OSCC was correlated with Lymphatic metastasis, TNM stage, E-cadherin, Vimentin, and MMP-2, but insignificantly Ki67. Kaplan-Meier analysis demonstrated that elevated expression of Mena was significantly associated with poor overall survival and disease-free survival of OSCC patients.ConclusionMena could be a novel biomarker for predicting the prognosis of OSCC patients, which supports a theoretical basis for developing molecular target therapy.

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Decreased Global Interest in Oral Cancer During the COVID-19 Pandemic

Cited by 5 publications

References 29 publications

Trends in the Incidence of Oral and Oropharyngeal Cancer in Southwest Iran from 2014 to 2019

Trends in the Incidence of Oral and Oropharyngeal Cancer in Southwest Iran from 2014 to 2019

Salivary Metabolomics for Oral Cancer Detection: A Narrative Review

Overexpression of Mena is associated with tumor progression and poor prognosis in oral squamous cell carcinoma via EMT

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