Decreased fibrinolytic potential in patients with idiopathic avascular necrosis and transient osteoporosis of the hip

Veldhuizen, Peter J. Van; Neff, James R.; Murphey, Mark D.; Bodensteiner, David; Skikne, Barry S.

doi:10.1002/ajh.2830440405

Cited by 112 publications

(58 citation statements)

References 29 publications

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“…Endothelial cells are important in the pathogenesis of diseases that involve thrombosis and/or inflammation (31). Changes in hemodynamics (22), vascular thrombotic tendency due to hypercoagulability (32), and hypofibrinolysis (9,33,34) have all been suggested to be significant factors in the pathogenesis of LCPD. Intron 4 and G894T polymorphisms of eNOS have been shown to decrease NO levels in human plasma (35,36).…”

Section: Discussionmentioning

confidence: 99%

Endothelial nitric oxide synthase gene polymorphism is associated with Legg-Calvé-Perthes disease

Zhao

Liao

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. The aim of this study was to assess the association of 27-bp variable number tandem repeat (VNTR) polymorphism in intron 4 and G894T polymorphism in exon 7 of the endothelial nitric oxide synthase (eNOS) gene with Legg-Calvé-Perthes disease (LCPD), and to provide a scientific basis for further research into the pathogenic mechanism. A total of 80 patients with LCPD and 100 healthy subjects were recruited in this case-control study. The 27-bp VNTR and G894T polymorphisms of the eNOS gene were genotyped using polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism, respectively, followed by agarose gel electrophoresis and DNA sequencing. Allelic and genotypic frequencies were computed in the two groups and subjected to statistical analysis. For the 27-bp VNTR polymorphism, individuals with LCPD showed a higher frequency of the ab genotype [27.5 vs. 14%; odds ratio (OR), 2.33; 95% confidence interval (CI), 1.10-4.92; P=0.024]. For the G894T polymorphism, the LCPD case group showed a higher frequency of the heterozygous genotype GT than the healthy control group (35 vs. 17%; OR, 2.67; 95% CI, 1.33-5.36; P=0.005). The results indicate that these eNOS gene polymorphisms may be a risk factor for LCPD. The 27-bp VNTR polymorphism in intron 4 and G894T polymorphism in exon 7 may be involved in the etiology of LCPD.

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Section: Discussionmentioning

confidence: 99%

Endothelial nitric oxide synthase gene polymorphism is associated with Legg-Calvé-Perthes disease

Zhao

Liao

et al. 2016

Experimental and Therapeutic Medicine

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“…1 Glueck and colleagues suggested that impaired fibrinolysis mediated by high PAI-1 was a common cause of idiopathic osteonecrosis, whereas high Lp (a) might play an etiologic role in secondary osteonecrosis. 22,23 Thereafter, studies of Glueck and his colleagues 6,24 and others 25,26 reported fibrinolytic or coagulation abnormalities. In a recent study, Bjorkman and colleagues reported that mutations in factor V or the prothrombin 20210A gene were significantly more frequent in patients with FHON than in a population of healthy control subjects.…”

Section: Discussionmentioning

confidence: 99%

Endothelial nitric oxide synthase gene polymorphisms in patients with nontraumatic femoral head osteonecrosis

Koo

Lee

et al. 2006

Journal Orthopaedic Research

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As endothelial nitric oxide synthase (eNOS) has beneficial effects on skeletal, vascular, and thrombotic systems, the association between nontraumatic femoral head osteonecrosis (FHON) and eNOS gene polymorphisms was investigated in Korean patients with FHON. Genomic DNA from 103 patients with nontraumatic FHON (idiopathic in 50, steroid-induced in 29, and alcohol abuse in 24) and 103 control subjects matched for gender and age (3-year range) was analyzed for the 27-bp repeat polymorphism in intron 4 and Glu298Asp polymorphism in exon 7. The frequencies of alleles and genotypes were compared between patients and control subjects. The frequency of 4a allele was significantly higher in total patients than control subjects [6.8% vs. 2.4%, p ¼ 0.0345, odds ratio (OR) 2.931]. In subgroup analysis, the 4a allele significantly increased in patients with idiopathic FHON versus control subjects (9.0% vs. 2.4%, p ¼ 0.0297, OR 3.976). The frequency of the 4a/b genotype in total patients (13.6% vs. 4.9%, p ¼ 0.0302, OR 3.083) as well as patients with idiopathic FHON (18.0% vs. 4.9%, p ¼ 0.0246, OR 4.302) was higher than control subjects. The distribution of Glu298Asp polymorphisms was not significantly different between patients and control subjects. Microstellate polymorphism in intron 4 of eNOS polymorphism was significantly associated with idiopathic FHON in Korean patients. Because 4a allele is associated with lower synthesis of eNOS, these results suggest that carrier state of 4a allele in intron 4 might be a genetic risk factor of FHON and could provide insight into the protective role of nitric oxide in the pathogenesis of FHON. ß

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“…Thromboembolic disease and hypercoaguable states are well described risk factors for osteonecrosis (29,30). Alterations in coagulation with an increased tendency to thromboembolic disease have been described in HIVinfected patients (31,32).…”

Section: Discussionmentioning

confidence: 99%

Osteonecrosis in HIV: A Case-Control Study

Scribner

Troia-Cancio

Cox

et al. 2000

Journal of Acquired Immune Deficiency Syndromes

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Decreased fibrinolytic potential in patients with idiopathic avascular necrosis and transient osteoporosis of the hip

Cited by 112 publications

References 29 publications

Endothelial nitric oxide synthase gene polymorphism is associated with Legg-Calvé-Perthes disease

Endothelial nitric oxide synthase gene polymorphism is associated with Legg-Calvé-Perthes disease

Endothelial nitric oxide synthase gene polymorphisms in patients with nontraumatic femoral head osteonecrosis

Osteonecrosis in HIV: A Case-Control Study

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