Decreased expression of USP9X is associated with poor prognosis in Chinese pancreatic ductal adenocarcinoma patients

Liu, Wei; Huo, Yan‐Miao; Yang, Jianyu; Fu, Xueliang; Yang, Minwei; Tao, Ling‐Ye; Liu, Dejun; Zhang, Junfeng; Hua, Rong; Sun, Yongwei

doi:10.3892/ol.2018.8452

Cited by 2 publications

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…USP9X is downregulated in pancreatic PDAC cell lines and in over 50% of PDAC tumors. It serves as a tumor suppressor gene, and its expression is inversely correlated with metastasis and poor post-surgical survival [ 156 ]. USP9X knockdown in mouse PDAC cells suppressed anoikis, partially by disabling the Usp9x/Itch pathway.…”

Section: Pancreatic Cancermentioning

confidence: 99%

Deubiquitinases in Cancers: Aspects of Proliferation, Metastasis, and Apoptosis

Liu

LEUNG

Liang

et al. 2022

Cancers

View full text Add to dashboard Cite

Deubiquitinases (DUBs) deconjugate ubiquitin (UBQ) from ubiquitylated substrates to regulate its activity and stability. They are involved in several cellular functions. In addition to the general biological regulation of normal cells, studies have demonstrated their critical roles in various cancers. In this review, we evaluated and grouped the biological roles of DUBs, including proliferation, metastasis, and apoptosis, in the most common cancers in the world (liver, breast, prostate, colorectal, pancreatic, and lung cancers). The current findings in these cancers are summarized, and the relevant mechanisms and relationship between DUBs and cancers are discussed. In addition to highlighting the importance of DUBs in cancer biology, this study also provides updated information on the roles of DUBs in different types of cancers.

show abstract

Section: Pancreatic Cancermentioning

confidence: 99%

Deubiquitinases in Cancers: Aspects of Proliferation, Metastasis, and Apoptosis

Liu

LEUNG

Liang

et al. 2022

Cancers

View full text Add to dashboard Cite

show abstract

“…USP9X is therefore identified as an anticancer target in osteosarcoma [44]. Conversely, USP9X has tumor suppressor functions in certain types of cancer, such as colorectal cancer [45] and pancreatic ductal adenocarcinoma [46]. It has been reported that USP9X is an integral component of centrosome and regulates centrosome duplication [38,47,48].…”

Section: Introductionmentioning

confidence: 99%

DDX3 interacts with USP9X and participates in deubiquitination of the anti‐apoptotic protein MCL1

Lai

Chen

et al. 2021

The FEBS Journal

View full text Add to dashboard Cite

Here, we describe a novel interaction between the RNA helicase DDX3 and the deubiquitinase ubiquitin-specific peptidase 9 X-linked (USP9X) in human cells. Domain mapping studies reveal that the C-terminal region of DDX3 interacted with the N terminus of USP9X. USP9X was predominantly localized in the cytoplasm where the interaction between DDX3 and USP9X occurred. USP9X was not visibly enriched in cytoplasmic stress granules (SGs) under oxidative stress conditions, whereas overexpression of GFP-DDX3 induced SG formation and recruited USP9X to SGs in HeLa cells. Luciferase reporter assays showed that depletion of USP9X had no significant effect on DDX3-mediated translation. Given that DDX3 is not ubiquitinated upon ubiquitin overexpression, it is unlikely that DDX3 serves as a substrate of USP9X. Importantly, we found that ubiquitinated MCL1 was accumulated upon depletion of USP9X and/or DDX3 in MG132-treated cells, suggesting that USP9X and DDX3 play a role in regulating MCL1 protein stability and anti-apoptotic function. This study indicates that DDX3 exerts anti-apoptotic effects probably by coordinating with USP9X in promoting MCL1 deubiquitination.

show abstract

Decreased expression of USP9X is associated with poor prognosis in Chinese pancreatic ductal adenocarcinoma patients

Cited by 2 publications

References 21 publications

Deubiquitinases in Cancers: Aspects of Proliferation, Metastasis, and Apoptosis

Deubiquitinases in Cancers: Aspects of Proliferation, Metastasis, and Apoptosis

DDX3 interacts with USP9X and participates in deubiquitination of the anti‐apoptotic protein MCL1

Contact Info

Product

Resources

About