Decreased expression of transmembrane TNFR2 in lung leukocytes subpopulations of patients with non-fibrotic hypersensitivity pneumonitis compared with the fibrotic disease

Chávez‐Galán, Leslie; Buendía-Roldán, Ivette; Castillo-Castillo, Kelly; Preciado-García, Mario; Ocaña-Guzmán, Ranferi; Salgado-Aguayo, Alfonso; Gaxiola, Miguel; Selman, Moisés

doi:10.1016/j.clim.2020.108424

Cited by 4 publications

(3 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, increasing TNF-α concentrations led to the preferential activation of proapoptotic signaling pathways in a cell population containing a high percentage of TNFR1-expressing cells, whereas proliferation was induced in a cell population containing a high percentage of TNFR2-expressing cells. These findings are consistent with the recent data that showed that high expressions of TNFR1 and TNFR2 were related to the hyperactivation and dysregulation of the immune response and to chronic systemic inflammation in the patients [14]. In contrast, the high expression of TNFR2 was associated with cell proliferation and a decrease in apoptosis, even for tumor cells, which contributed to their escape from immune surveillance [15,16].…”

Section: Discussionsupporting

confidence: 92%

Ligand-Regulated Expression of TNF Receptors 1 and 2 Determines Receptor-Mediated Functional Responses

Alshevskaya

Koneva

Belomestnova

et al. 2021

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Introduction: Modulating specific biological effects through the changes in cytokine receptors’ expression level remains poorly understood. This study aimed to investigate the influence of the dose-dependent effect of TNF on the balance between proapoptotic and proliferation response depending on the parameters of TNFR1/2 expression density. Methods: Tumor cell lines (HEp-2, K-562, MCF-7, ZR-75/1, MOLT-4, IM-9, and Raji) were characterized for TNFR1/2 co-expression using flow cytometry and were studied to reveal the dose-dependent effect of rhTNF on cell cycle and apoptosis parameters. The associations among the studied parameters were estimated by correlation and regression analysis. Results: It was found for ZR-75/1 cells (the cell line characterized by high expression of both types) that a dose-dependent increase in expression of both types of TNF-α receptors on cells reduces the proliferative activity of cells. For MOLT-4 cells (which are characterized by lower expression), an increase in proliferative response of cells was positively associated with the percentage of both TNFR1+ and TNFR2+ cells. However, opposite effects on the cells were shown for the K-562 and MCF-7 lines having a similar expression profile. A similarity (a large percentage of double-positive cells) was revealed for the lines having similar effects (K-562 and ZR-75/1). Conclusions: High expression of TNF receptor type 1 is not always associated with predominant activation of proapoptotic pathways. However, in the case of simultaneous high expression of both types of receptors, the proportion of double-positive cells is crucial for the activation of either the proapoptotic or proliferation pathways.

show abstract

Section: Discussionsupporting

confidence: 92%

Ligand-Regulated Expression of TNF Receptors 1 and 2 Determines Receptor-Mediated Functional Responses

Alshevskaya

Koneva

Belomestnova

et al. 2021

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…According to the latest classification (according to the New ATS/JRS/ALAT Clinical Practice Guideline), HP is divided into fibrotic and non-fibrotic forms: NFHP is a mild form of HP compared to FHP. However, NFHP often progresses to fibrosis, yet is recurrent [ 32 ]. Diffuse infiltrative parenchymal abnormalities with GGO or mosaic attenuation, as well as at least one abnormality suggesting small airway disease (ill-defined, 5 mm centrilobular nodules on inspiratory images or air trapping on expiratory images) are important HRCT characteristics of Typical NFHP.…”

Section: Imaging Of Hpmentioning

confidence: 99%

Hypersensitivity Pneumonitis: A Pictorial Review Based on the New ATS/JRS/ALAT Clinical Practice Guideline for Radiologists and Pulmonologists

2022

View full text Add to dashboard Cite

Hypersensitivity pneumonitis (HP) is a complicated and heterogeneous interstitial lung disease (ILD) caused by an excessive immune response to an inhaled antigen in susceptible individuals. Accurate diagnosis of HP is difficult and necessitates a detailed exposure history, as well as a multidisciplinary discussion of clinical, histopathologic, and radiologic data. We provide a pictorial review based on the latest American Thoracic Society (ATS)/Japanese Respiratory Society (JRS)/Asociación Latinoamericana del Tórax (ALAT) guidelines for diagnosing HP through demonstrating new radiologic terms, features, and a new classification of HP which will benefit radiologists and pulmonologists.

show abstract

“…It may be that impaired TNFR2 signaling can help facilitate traditionally fibrotic Th2/Th17 polarization, however, further studies are needed. In BALF from fibrotic and non-fibrotic hypersensitivity pneumonitis (HP) patients, transmembrane TNFR2 was elevated in fibrotic compared to non-fibrotic samples ( 26 ). In contrast, soluble TNFR2 and sTNF were both upregulated in non-fibrotic HP patients.…”

Section: Tnf : Tnfr1/tnfr2mentioning

confidence: 99%

TNF superfamily control of tissue remodeling and fibrosis

Steele,

Cheng,

Willicut

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

Fibrosis is the result of extracellular matrix protein deposition and remains a leading cause of death in USA. Despite major advances in recent years, there remains an unmet need to develop therapeutic options that can effectively degrade or reverse fibrosis. The tumor necrosis super family (TNFSF) members, previously studied for their roles in inflammation and cell death, now represent attractive therapeutic targets for fibrotic diseases. In this review, we will summarize select TNFSF and their involvement in fibrosis of the lungs, the heart, the skin, the gastrointestinal tract, the kidney, and the liver. We will emphasize their direct activity on epithelial cells, fibroblasts, and smooth muscle cells. We will further report on major clinical trials targeting these ligands. Whether in isolation or in combination with other anti-TNFSF member or treatment, targeting this superfamily remains key to improve efficacy and selectivity of currently available therapies for fibrosis.

show abstract

Decreased expression of transmembrane TNFR2 in lung leukocytes subpopulations of patients with non-fibrotic hypersensitivity pneumonitis compared with the fibrotic disease

Cited by 4 publications

References 36 publications

Ligand-Regulated Expression of TNF Receptors 1 and 2 Determines Receptor-Mediated Functional Responses

Ligand-Regulated Expression of TNF Receptors 1 and 2 Determines Receptor-Mediated Functional Responses

Hypersensitivity Pneumonitis: A Pictorial Review Based on the New ATS/JRS/ALAT Clinical Practice Guideline for Radiologists and Pulmonologists

TNF superfamily control of tissue remodeling and fibrosis

Contact Info

Product

Resources

About