Decreased Expression of Na+/K+-ATPase, NHE3, NBC1, AQP1 and OAT in Gentamicin-induced Nephropathy

Bae, Woo Kyun; Lee, Jong Un; Park, Jeong Woo; Bae, Eun Hui; Kwon, Seong; Kim, Suhn Hee; Kim, Soo Wan

doi:10.4196/kjpp.2008.12.6.331

Cited by 14 publications

(14 citation statements)

References 15 publications

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“…57 This report was concurrent with a report of a partial product of truly novel gene (Slc4a8), which was also then named NBC3 (35). This product has since been renamed NDCBE.…”

Section: I) Nbcn1 Is An Electroneutral Ncbt With Poor Didssensitivitymentioning

confidence: 76%

“…308). In rats treated with gentamycin for 7 days, renal NBCe1 protein abundance is decreased by half (57). The abundance of other renal Na ϩ transporters, namely, NHE3 and the Na-K pump, and the water/carbon dioxide channel AQP1 are also reduced under these conditions (57).…”

Section: E) Decreased Protein Abundance In Kidney During Gentamycin-imentioning

confidence: 98%

“…Unfortunately, because of differences between the SBC2/hNBC2 and mNBC3 cDNA sequences, 56 mNBC3 was interpreted as the product of a novel gene, which was assigned the name SLC4A7 (765). 57 By the time NBC2 and NBC3 had been rationalized as alternative products of the same gene (139, 189), the designation SLC4A7 had already been introduced to the literature. As a consequence, the designation SLC4A6, which had never been mentioned in the literature, was withdrawn.…”

Section: Nbcn1 (Slc4a7)mentioning

confidence: 99%

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The Divergence, Actions, Roles, and Relatives of Sodium-Coupled Bicarbonate Transporters

Parker

Boron

2013

Physiological Reviews

246

262

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The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1-3), five Na(+)-coupled HCO3(-) transporters (NCBTs), and two other unusual members (AE4, BTR1). In this review, we mainly focus on the five mammalian NCBTs-NBCe1, NBCe2, NBCn1, NDCBE, and NBCn2. Each plays a specialized role in maintaining intracellular pH and, by contributing to the movement of HCO3(-) across epithelia, in maintaining whole-body pH and otherwise contributing to epithelial transport. Disruptions involving NCBT genes are linked to blindness, deafness, proximal renal tubular acidosis, mental retardation, and epilepsy. We also review AE1-3, AE4, and BTR1, addressing their relevance to the study of NCBTs. This review draws together recent advances in our understanding of the phylogenetic origins and physiological relevance of NCBTs and their progenitors. Underlying these advances is progress in such diverse disciplines as physiology, molecular biology, genetics, immunocytochemistry, proteomics, and structural biology. This review highlights the key similarities and differences between individual NCBTs and the genes that encode them and also clarifies the sometimes confusing NCBT nomenclature.

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“…57 This report was concurrent with a report of a partial product of truly novel gene (Slc4a8), which was also then named NBC3 (35). This product has since been renamed NDCBE.…”

Section: I) Nbcn1 Is An Electroneutral Ncbt With Poor Didssensitivitymentioning

confidence: 76%

Section: E) Decreased Protein Abundance In Kidney During Gentamycin-imentioning

confidence: 98%

Section: Nbcn1 (Slc4a7)mentioning

confidence: 99%

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The Divergence, Actions, Roles, and Relatives of Sodium-Coupled Bicarbonate Transporters

Parker

Boron

2013

Physiological Reviews

246

262

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“…Accordingly, transporter mutations cause many types of diseases. For example, the hyperactive NBCe1 during reperfusion leads to Na + and Ca 2+ overloading and myocardial damage [33], whereas impaired sodium reabsorption caused by gentamicin-induced nephropathy is probably due to the downregulation of sodium transporters, such as NBC and NHE3, suggesting decreased activity of sodium transporters in rat proximal nephrons [34]. Furthermore, inactivating mutation of NBCe1 was observed to be associated with severe proximal renal tubular acidosis accompanied by ocular abnormalities [35][36][37] and severe growth retardation [36].…”

Section: Pathophysiology Of Nbce1mentioning

confidence: 99%

Nanomaterials‐Based Approaches for the Modulation of Sodium Bicarbonate Cotransporters

Hong

2015

Journal of Nanomaterials

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HCO3-and fluid secretion are major functions of all epithelia, and alterations inHCO3-secretion by sodium bicarbonate cotransporters are associated with many epithelial diseases, such as renal, ocular, and dental abnormalities. Electrolyte and fluid exits are synergistically mediated by the intracellular second messengers, cAMP and Ca2+, and this raises the possibility that ion transporters are involved in simple secretion and more complicated forms of regulation. Evidence indicates thatHCO3-transport is regulated by the assemblage of Na+-HCO3-cotransporters (NBCs) into complexes by multiple regulatory factors. Recently the specific regulatory functions of factors that interact with NBCe1, especially NBCe1-B, have been elucidated. In this review, I focus on the structural characteristics of electrogenic NBCe1, pathophysiology of NBCe1, and molecular mechanisms responsible for transporter regulation. Moreover I propose the possibility to apply nanomaterials combined with regulatory factors for modulating the activity of NBC transporters as a potential development of therapeutic drug.

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“…It plays important roles in systemic and cellular pH homeostasis and trans-epithelial solute transport together with other members of the bicarbonate transporter superfamily[11-13]. Its activity was first identified in the kidney of the salamander Ambystoma tigrinum [14].…”

Section: Introductionmentioning

confidence: 99%

Na⁺/HCO₃^-cotransporter is expressed on β and α cells during rat pancreatic development

Cao

Xia

Shi

et al. 2016

WJG

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AIMTo determine the expression and localization of the electrogenic Na+/HCO3- cotransporter (NBC1) in rat pancreas during development.METHODSThe rat pancreas from postnatal and embryos removed from the uterus of pregnant rats that had been sacrificed by CO2 asphyxiation were used. Rat pancreas from embryonic day (E) 15.5 and E18.5 rat embryos was isolated under a stereomicroscope. Rat pancreas from postnatal (P) days 0, 7, 14, 21 and adult was directly isolated by the unaided eye. The RT-PCR analysis of the NBC1 specific region on rat pancreas tissues from different developmental stages. The two antibodies which target the NBC1 common COOH-terminal region and NH2-terminal region detected a clear band of about 145 kDa in the Western blot analysis. The localization of NBC1 was examined by immuno-fluorescence detection.RESULTSThe results revealed the first peak of NBC1 expression at E18.5 and the second peak at P14. Meanwhile, the low NBC1 expression occurred at P7 and adult stages. Our results demonstrated, for the first time, the presence of NBC1 in the plasma membrane of β and α cells, as well as in the basolateral membrane of acinar cells of the rat pancreas at different stages of development.CONCLUSIONThe data strongly suggests that NBC1 is diversely expressed in the pancreas at different developmental stages, where it may exert its functions in pancreatic development especially islet cell growth through HCO3- transport and pH regulation.

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Decreased Expression of Na+/K+-ATPase, NHE3, NBC1, AQP1 and OAT in Gentamicin-induced Nephropathy

Cited by 14 publications

References 15 publications

The Divergence, Actions, Roles, and Relatives of Sodium-Coupled Bicarbonate Transporters

The Divergence, Actions, Roles, and Relatives of Sodium-Coupled Bicarbonate Transporters

Nanomaterials‐Based Approaches for the Modulation of Sodium Bicarbonate Cotransporters

Na⁺/HCO₃^-cotransporter is expressed on β and α cells during rat pancreatic development

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Decreased Expression of Na+/K+-ATPase, NHE3, NBC1, AQP1 and OAT in Gentamicin-induced Nephropathy

Cited by 14 publications

References 15 publications

The Divergence, Actions, Roles, and Relatives of Sodium-Coupled Bicarbonate Transporters

The Divergence, Actions, Roles, and Relatives of Sodium-Coupled Bicarbonate Transporters

Nanomaterials‐Based Approaches for the Modulation of Sodium Bicarbonate Cotransporters

Na+/HCO3-cotransporter is expressed on β and α cells during rat pancreatic development

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Product

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Na⁺/HCO₃^-cotransporter is expressed on β and α cells during rat pancreatic development