Decreased expression of microRNA-31 associates with aggressive tumor progression and poor prognosis in patients with bladder cancer

Wang, S.; Li, Q.; Wang, K.; Dai, Yaozhang; Yang, Jianfu; Xue, Sheng; Han, Feng; Zhang, Q.; Liu, Jiajia; Wu, Wei

doi:10.1007/s12094-013-1014-4

Cited by 50 publications

(37 citation statements)

References 28 publications

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“…Functional studies performed in cancer ce ll lines or animal models of various cancers suggest that, miRNAs can function as tumor suppressors, oncogenes, and regulate cancer pathways (Farazi et al, 2011). Aberrant expression of specific miRNAs has been reported in many tumor types 1 such as CRC, breast cancer, cervical cancer, non-small cell lung cancer, ovarian cancer and bladder cancer as well as being associated with patients' survival data, metastasis, and other clinicopathological factors (Toyama et al, 2012;Wan et al, 2012;Shen et al, 2013;Wang et al, 2013;Xiao et al, 2013;Liu et al, 2014;Xu et al, 2014). A previous study showed that miR-32 expression was upregulated in CRC tissues, and high expression was significantly correlated with the tumor stage, distal metastases and poor prognoses (Wu et al, 2013b).…”

Section: Introductionmentioning

confidence: 99%

Expression and Clinical Significance of MicroRNA-376a in Colorectal Cancer

Wu²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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The incidence of colorectal cancer (CRC) is increasing in many Asian countries and microRNAs have already been proven to be associated with tumorigenesis. Currently, microRNA-376a (miR-376a) expression and association with clinical factors in CRC remains unclear. In this study, real-time quantitative reverse transcriptasepolymerase chain reaction (qRT-PCR) was carried out on 53 matched pairs of CRC and adjacent normal mucosa to investigate the expression levels of miR-376a. According to the high or low expression of miR-376a, patients were divided into two groups. The relationship between miR-376a expression and clinicopathological factors of 53 patients was evaluated. Survival analysis of 53 CRC patients was performed with clinical followup information and survival curves were assessed by the Kaplan-Meier method. Immunohistochemistry (IHC) staining was performed on sections of paraffin-embedded tissue to investigate the vascular endothelial growth factor (VEGF) expression. MiR-376a showed low expression in cancer tissues compared to the adjacent normal tissues and altered high miR-376a expression tended to be positively correlated with advanced lymph node metastasis and shorter patient survival. VEGF IHC positivity was significantly more common in patients with high expression levels of miR-376a.Those results demonstrated that miR-376a may be a meaningful prognostic biomarker and potential therapeutic target in colorectal cancer.

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Section: Introductionmentioning

confidence: 99%

Expression and Clinical Significance of MicroRNA-376a in Colorectal Cancer

Wu²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Bladder cancer has diverse functional and biological characteristics, which include frequent recurrences and poor clinical outcome when tumor progresses to muscle invasive stage [14]. Numerous biomarkers and histopathological evaluation, such as tumor stage, tumor grade, and lymph node, have been investigated as prognostic indicators [15,16].…”

Section: Discussionmentioning

confidence: 99%

“…miRNAs are involved in a wide range of biological cellular functions, such as differentiation, apoptosis, and proliferation [3,6,12,14,21]. Additionally, the aberrant expression of miRNAs can be tracked in the pathogenesis, progression, and metastasis of malignant tumors.…”

Section: Discussionmentioning

confidence: 99%

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Increased miR-141 expression is associated with diagnosis and favorable prognosis of patients with bladder cancer

Xiao-lin

Xie

Zhu³

et al. 2014

Tumor Biol.

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The aims of this study are to analyze the association of microRNA-141 (miR-141) with the clinicopathological parameters of bladder cancer and evaluate the value of miR-141 in predicting the prognosis of bladder cancer. In this study, 114 patients with bladder cancer were enrolled in the study, and tissue specimens were obtained from the tumor zone and from adjacent normal area. miR-141 expression was determined using SYRB Green quantitative real-time polymerase chain reaction assay and was further correlated with patients' clinicopathological parameters and the follow-up data. The results indicated that miR-141 was upregulated in malignant bladder specimens compared with normal ones (P < 0.001). miR-141 expression was significantly associated with tumor stage (P < 0.001), tumor grade (P < 0.001), and muscle invasion status (P < 0.001). Log-rank test showed that the higher miR-141 expression was associated with longer disease-specific survival of the patients with bladder cancer (P < 0.001), which was also proven by univariate and multivariate Cox regression analysis (P < 0.001 and P = 0.039, respectively). Focusing on patients with non-muscle invasive bladder cancer, univariate analysis using log-rank test and Cox regression analysis found that patients with high miR-141 expression experienced longer disease-free survival (P = 0.031 and P = 0.040, respectively) and disease-specific survival (P = 0.028 and P = 0.038, respectively), which was confirmed by multivariate Cox regression analysis (P = 0.036 and P = 0.042, respectively). In conclusion, this study showed that miR-141 may contribute to the progression of bladder cancer and its upregulation may be independently associated with favorable prognosis of bladder cancer, suggesting that miR-141 might serve as a promising biological marker for further risk stratification in the management of bladder cancer.

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“…재미있게도 miR-31은 다양한 암종 별로 그 발현 양상이 다르다고 알려져 있다. 방광암 [28,30], 유방암 [2,24,26], 식도암 [19], 난소암 [8], 전립선암 [3,10,27] 등에서는 miR-31의 발현이 저해되어 있다고 보고 되어있는 반면에 대장 암 [6,20,23,25,31], 폐암 [17,18] MicroRNA ( …”

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Overexpression of MicroRNA-31 as a Promising Biomarker for Prognosis and Metastasis in Human Colorectal Cancer

Hur¹

2016

Journal of Life Science

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Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer-related death worldwide. Although several diagnostic and therapeutic tools have been available, CRC remains difficult to complete cure because of insufficient understanding of the molecular mechanisms underlying this disease progression. MicroRNAs (miRNAs) are small non-coding RNA molecules that strongly regulate gene expression via transcriptional and translational control mechanisms. Many crucial cellular pathways are frequently disrupted in cancer development process due to dysregulation of several miRNAs. Mir-31 functions as an oncogene that modulate expression of multiple cancer related genes. Thus, we aimed to demonstrate clinical relevance of miR-31 in human CRC. Quantitative RT-PCR analysis of miR-31 expression was performed in 175 CRC tissues and 16 normal colonic mucosa (NM). Next, we investigated clinical significances of miR-31 expression in various clinicopathologic features in CRC patients cohort. Mir-31 was significantly up-regulated in CRC tissues compared to NM. In CRC tissues, miR-31 expression level was significantly elevated in a stage-dependent manner, which was associated with poor survival in patients with CRC. High miR-31 levels in CRC tissues significantly correlated with poor prognosis (hazard ratio [HR]=2.4) as well as distant metastasis (odds ratio [OR]=2.3). In conclusion, we identified clinical significance of miR-31 expression in CRC. High miR-31 expression may be clinically able to use as a biomarker for CRC prognosis and predicting metastasis.

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Decreased expression of microRNA-31 associates with aggressive tumor progression and poor prognosis in patients with bladder cancer

Abstract: These findings show that miR-31 may contribute to the progression of bladder cancer and its downregulation may be independently associated with unfavorable PFS and OS, suggesting that miR-31 might be a promising marker for further risk stratification in the treatment of this cancer.

Cited by 50 publications

References 28 publications

Expression and Clinical Significance of MicroRNA-376a in Colorectal Cancer

Expression and Clinical Significance of MicroRNA-376a in Colorectal Cancer

Increased miR-141 expression is associated with diagnosis and favorable prognosis of patients with bladder cancer

Overexpression of MicroRNA-31 as a Promising Biomarker for Prognosis and Metastasis in Human Colorectal Cancer

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