Decreased Expression of Catechol-O-Methyltransferase in the Renal Cortex of Malignant Spontaneously Hypertensive Rats

Ooshima, Kana; Ozaki, Shingen; Tabuchi, Masaki; Higashino, Hideaki; Honda, Eiko; Park, Ah-Mee; Arima, Shuji; Munakata, Hiroshi

doi:10.1620/tjem.219.331

Cited by 6 publications

(1 citation statement)

References 18 publications

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“…Metabolism by catechol‐ O ‐methyltransferase (COMT) is one of the inactivation pathways of CA , important hormones for regulating BP both in central and peripheral sympathetic nerves. Several hormones, including cholecystokinin (CCK), are also involved in regulating BP via sympathetic nerve activity .…”

Section: Introductionmentioning

confidence: 99%

Effects of Sleeve Gastrectomy on Blood Pressure and the Renal Renin–Angiotensin System in Rats with Diet‐Induced Obesity

Yoshida

Gotoh

Masaki

et al. 2019

Obesity

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Objective Sleeve gastrectomy (SG) has been reported to decrease blood pressure (BP), although the reason has not been revealed. The present study aimed to establish the reason why SG decreases BP. Methods Male Sprague–Dawley rats were subjected to surgical (sham operation or SG) and dietary interventions (fed a normal diet or high‐fat diet ad libitum or fed by pair‐feeding [PF]). Systolic BP (SBP), urinary sodium excretion, and endocrine parameters were examined 4 weeks after surgery. Results Both SG and PF rats had reduced body weight compared with SO rats fed normal diet or high‐fat diet ad libitum. SG rats exhibited a reduction in SBP compared with PF, which was associated with a reduction in renal renin, angiotensin II, and catechol‐O‐methyltransferase levels (P < 0.01 for each). SG increased plasma cholecystokinin (CCK) levels compared with PF (P < 0.0001 for each), whereas glucagon‐like peptide 1 and peptide YY were not changed in fasting. Exogenous administration of CCK reduced renal catechol‐O‐methyltransferase (P = 0.0233), renin (P < 0.0001), and angiotensin II (P < 0.0001) levels and SBP (P = 0.0053). Conclusions SG reduced SBP, at least in part, through suppression of sympathetic nerve action by elevation of CCK, which was followed by suppression of the intrarenal renin–angiotensin system.

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Section: Introductionmentioning

confidence: 99%

Effects of Sleeve Gastrectomy on Blood Pressure and the Renal Renin–Angiotensin System in Rats with Diet‐Induced Obesity

Yoshida

Gotoh

Masaki

et al. 2019

Obesity

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Catechol-O-Methyltransferase (COMT): An Update on Its Role in Cancer, Neurological and Cardiovascular Diseases

Bastos

Gomes

Ribeiro

2017

Reviews of Physiology, Biochemistry and Pharmacology

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Catechol-O-methyltransferase (COMT) is an enzyme that catalyses the methylation of catechol substrates, classically in catecholamine metabolism, but also acting upon other substrates such as oestrogen and polyphenols. Although its classical function has been established for more than five decades, an ever expanding COMT role in other pathways and diseases has become a subject of active study in recent years. The most highlighted domains are related with COMT involvement in neuropsychiatric disorders and its role in the neurobiology of cognition, behaviour, emotions, pain processing and perception, sleep regulation, addictive behaviour and neurodegeneration. Nonetheless, great attention is also being devoted to a possible COMT contribution to the development of cardiovascular disorders and hormonally influenced diseases, including cancer. This review aims to update the role of COMT function and its involvement in cardiovascular and neurological disorders.

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2-Methoxyestradiol ameliorates metabolic syndrome-induced hypertension and catechol-O-methyltransferase inhibited expression and activity in rats

Azhar

Zaher

Ashour

et al. 2020

European Journal of Pharmacology

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Decreased Expression of Catechol-O-Methyltransferase in the Renal Cortex of Malignant Spontaneously Hypertensive Rats

Cited by 6 publications

References 18 publications

Effects of Sleeve Gastrectomy on Blood Pressure and the Renal Renin–Angiotensin System in Rats with Diet‐Induced Obesity

Effects of Sleeve Gastrectomy on Blood Pressure and the Renal Renin–Angiotensin System in Rats with Diet‐Induced Obesity

Catechol-O-Methyltransferase (COMT): An Update on Its Role in Cancer, Neurological and Cardiovascular Diseases

2-Methoxyestradiol ameliorates metabolic syndrome-induced hypertension and catechol-O-methyltransferase inhibited expression and activity in rats

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