Decreased expression of 14-3-3σ in neuroendocrine tumors is independent of origin and malignant potential

Yatabe, Yasushi; Osada, Hiroyuki; Tatematsu, Yoshio; Mitsudomi, Tetsuya; Takahashi, Takashi

doi:10.1038/sj.onc.1206014

Cited by 29 publications

(26 citation statements)

References 53 publications

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“…Including our series, epigenetic transcriptional silencing of 14-3-3s has been demonstrated in malignancies from prostate, endometrium, ovary, breast, lung, liver, skin, stomach and oral squamous cell carcinoma. [15][16][17][18]20,21,[24][25][26] Another recent immunohistochemical study has shown loss of 14-3-3s expression in prostate cancer. 27 By preselecting areas of highest Gleason score in their tumor biopsies and by using a different 14-3-3s antibody, these authors find low or absent levels of 14-3-3s in an even higher percentage of tumors.…”

Section: Discussionmentioning

confidence: 99%

“…In our tumors, we did not analyze the p53 mutation but previous studies showed that no correlation between genomic alterations of p53 and 14-3-3s expression was observed in various cancer cell lines, and in primary vulval squamous cancer and primary neuroendocrine tumors. 16,25,26 Like p53, its homologs p63 and p73 can trigger expression of 14-3-3s. In addition, repression of 14-3-3s expression was seen by a tumor-associated p63 splice variant (Delta Np63) in vitro.…”

Section: Discussionmentioning

confidence: 99%

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Downregulation of 14-3-3σ in ovary, prostate and endometrial carcinomas is associated with CpG island methylation

et al. 2005

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Downregulation of 14-3-3σ in ovary, prostate and endometrial carcinomas is associated with CpG island methylation

et al. 2005

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“…40 Inactivation of this gene by epigenetic silencing appears to be an early event in vulval squamous neoplasia 41 and several other malignancies. [42][43][44] A protein which has thus far not been directly implicated in cancer is Endonuclease III homolog 1 (HNTH1) (cluster 7A, C04i). This enzyme specifically cleaves oxidatively damaged pyrimidines in DNA.…”

Section: Discussionmentioning

confidence: 99%

Detection of cancer‐related gene expression profiles in severe cervical neoplasia

Sopov

Magbagbeolu

et al. 2004

Intl Journal of Cancer

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The molecular signatures of 20 severe cervical intraepithelial neoplasia (CIN3) cases and 10 cervical squamous cell cancers were determined to define cancer-related gene expression profiles. RNAs extracted from microdissected tissues were amplified by SMART technology and used as probes for hybridization of commercially available cDNA array filters comprising 1,176 cancer-related genes. Ninetytwo differentially expressed genes were identified by comparison of pooled cDNA from CIN3 vs. cervical cancer. Heterogeneity in expression of this subset of genes was then analyzed for each biopsy using an algorithm for self-organizing maps. For several gene clusters, the expression pattern for CIN3 differed significantly from that of cancer. Moreover, hierarchical clustering revealed significant differences in distribution of CIN and cancer. Several CIN cases were more strongly related to cancer, suggesting that gene expression profiling may be useful for subdividing pathologically indistinguishable precancers into different biologic entities. This approach also provides a basis for the identification of putative prognostic markers and for targeted molecular therapy.

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“…It is induced by DNA damage and appears to be required for maintaining the G 2 /M checkpoint in epithelial cells, and its gene is directly regulated by p53 (Hermeking, 2003). Absent or decreased expression of 14-3-3 s has been found in different cancers, such as vulvar cancer (Gasco et al, 2002), breast cancer (Urano et al, 2002), bladder cancer (Ostergaard et al, 1997) and neuroendocrine lung tumours (Yatabe et al, 2002). Figure 4 Cluster analysis using the expression patterns of 11 identified proteins that are downregulated in both vaginal and cervical carcinoma.…”

Section: Tumour Suppressor Proteins and Oncoproteinsmentioning

confidence: 99%

Differential tissue-specific protein markers of vaginal carcinoma

et al. 2009

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The objective was to identify proteins differentially expressed in vaginal cancer to elucidate relevant cancer-related proteins. A total of 16 fresh-frozen tissue biopsies, consisting of 5 biopsies from normal vaginal epithelium, 6 from primary vaginal carcinomas and 5 from primary cervical carcinomas, were analysed using two-dimensional gel electrophoresis (2-DE) and MALDI-TOF mass spectrometry. Of the 43 proteins identified with significant alterations in protein expression between non-tumourous and tumourous tissue, 26 were upregulated and 17 were downregulated. Some were similarly altered in vaginal and cervical carcinoma, including cytoskeletal proteins, tumour suppressor proteins, oncoproteins implicated in apoptosis and proteins in the ubiquitin -proteasome pathway. Three proteins were uniquely altered in vaginal carcinoma (DDX48, erbB3-binding protein and biliverdin reductase) and five in cervical carcinoma (peroxiredoxin 2, annexin A2, sarcomeric tropomyosin kappa, human ribonuclease inhibitor and prolyl-4-hydrolase beta). The identified proteins imply involvement of multiple different cellular pathways in the carcinogenesis of vaginal carcinoma. Similar protein alterations were found between vaginal and cervical carcinoma suggesting common tumourigenesis. However, the expression level of some of these proteins markedly differs among the three tissue specimens indicating that they might be useful molecular markers.

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Decreased expression of 14-3-3σ in neuroendocrine tumors is independent of origin and malignant potential

Cited by 29 publications

References 53 publications

Downregulation of 14-3-3σ in ovary, prostate and endometrial carcinomas is associated with CpG island methylation

Downregulation of 14-3-3σ in ovary, prostate and endometrial carcinomas is associated with CpG island methylation

Detection of cancer‐related gene expression profiles in severe cervical neoplasia

Differential tissue-specific protein markers of vaginal carcinoma

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