2019
DOI: 10.1016/j.molcel.2019.07.038
|View full text |Cite
|
Sign up to set email alerts
|

Decreased Enhancer-Promoter Proximity Accompanying Enhancer Activation

Abstract: Highlights d Super-resolution microscopy reveals increased enhancerpromoter separation upon activation d Synthetic enhancer activation supports decreased enhancerpromoter proximity d Enhancer-promoter separation can be driven by poly(ADPribose) polymerase 1

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

26
229
1

Year Published

2019
2019
2023
2023

Publication Types

Select...
7
2

Relationship

0
9

Authors

Journals

citations
Cited by 243 publications
(256 citation statements)
references
References 77 publications
(111 reference statements)
26
229
1
Order By: Relevance
“…Here, we integrate caQTL and eQTL studies as an additional method to both identify the genes regulated by REs and to propose causal variants altering the function of these REs. This is complementary to chromatin interaction assays, such as Hi-C, which demonstrate physical interaction with a promoter region, but are not always indicative of regulation (Alexander et al, 2019;Benabdallah et al, 2019) . caQTL and eQTL studies require genetic variation to be present in a population in order to detect their impact.…”
Section: Discussionmentioning
confidence: 97%
“…Here, we integrate caQTL and eQTL studies as an additional method to both identify the genes regulated by REs and to propose causal variants altering the function of these REs. This is complementary to chromatin interaction assays, such as Hi-C, which demonstrate physical interaction with a promoter region, but are not always indicative of regulation (Alexander et al, 2019;Benabdallah et al, 2019) . caQTL and eQTL studies require genetic variation to be present in a population in order to detect their impact.…”
Section: Discussionmentioning
confidence: 97%
“…Maintenance of enhancer-promoter looping is thought to be crucial for gene activation, but emerging evidence and the data presented here suggest that enhancer-promoter contact and gene activation may be partially separable events. Importantly, physical interaction with the promoter may not be necessary for all enhancers 5,6 , although it appears to be a requisite for most. At the same time, enhancer-promoter looping alone is not sufficient for activation, as enhancer-promoter contacts have been observed in the absence of transcription 57,58 .…”
Section: Discussionmentioning
confidence: 99%
“…Enhancers can be situated far away from the genes they regulate 1,4 . Although not always the case 5,6 , at many gene loci proximity between enhancers and promoters is thought to be essential for enhancer function and gene activation 7,8 . How these enhancer-promoter interactions are initiated and maintained is not clearly understood.…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, advances in live cell imaging will complement the continually improving structural and mechanistic models of Pol II transcription. Despite recent progress (Liu and Tjian 2018), many basic questions remain unanswered, such as (1) how genomes are organized in the three-dimensional space of the nucleus (Furlong and Levine 2018), (2) how transcriptional bursting occurs (Donovan et al 2019;Rodriguez et al 2019;Stavreva et al 2019), (3) how enhancer-promoter interactions are controlled (Lim et al 2018;Li et al 2019), (4) how enhancers actually work to activate gene expression (Benabdallah et al 2019;Heist et al 2019), (5) how gene expression patterns are maintained (i.e., active vs. repressed) through mitosis (Teves et al 2018), and so on. Also, what set of cofactors are essential for these processes, and which are redundant, context-specific, or cell type-specific?…”
Section: Concluding Remarks and Future Directionsmentioning
confidence: 99%